GERTY THERESA CORI

August 8, 1896-October 26, 1957

BY JOSEPH LARNER

GERTY AND CARL CORI's most significant contributions were the establishment of the cycle of carbohydrates known as ''the Cori Cycle,'' the isolation of glucose 1-phosphate, and the discovery of phosphorylase and phosphoglucomutase. These discoveries established the enzymatic pathways of glycogenolysis and glycolysis.

In glycogen metabolism, Gerty Cori pioneered in the discovery of the debranching enzyme amylo-1,6-glucosidase and its use in the elucidation of glycogen structure by serial enzymatic degradation. This pioneering work led to the elucidation of the enzymatic defects in the glycogen storage diseases. Her studies, therefore, extended fundamental scientific discoveries into the clinical arena, most particularly in the field of pediatrics, her original area of clinical interest and specialization.

Gerty Theresa Radnitz was born on August 8, 1896, in Prague, at that time part of the Austro-Hungarian empire. Otto Radnitz, her father, was director general of a sugar refinery in Bohemia. Her mother's brother was professor of pediatrics at the University of Prague. Gerty studied at home until the age of ten, when she went to a girls' preparatory school, from which she graduated in 1912. In 1914, after passing her final examination (matura) at the Tetschen



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