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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under both the Academy’s 1863 congressional charter responsibility to be an adviser to the federal government and its own initiative in identifying issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine.

This project was funded by the National Center for Human Genome Research of the National Institutes of Health (Contract No. NO1-HG-0-001) and by the Health Effects Research Program of the Department of Energy (Contract No. DE-FG05-91ER61115; DOE’s support does not constitute an endorsement of the views expressed in the report). The Lucille P. Markey Charitable Trust provided supplemental funding of the study. Additional support for this project was provided by independent Institute of Medicine funds.

Library of Congress Cataloging-in-Publication Data

Assessing genetic risks : implications for health and social policy / Lori B. Andrews . . . [et al.] editors.

p. cm.

Includes bibliographical references and index.

ISBN 0-309-04798-6

1. Medical genetics—Social aspects. 2. Human chromosome abnormalities—Diagnosis—Social aspects. 3. Medical policy—United States. I. Andrews, Lori B., 1952- .

[DNLM: 1. Hereditary Diseases—genetics. 2. Hereditary Diseases—epidemiology. 3. Risk Factors. 4. Health Policy—United States. QZ 50 A846 1994]

RB155.A76 1994



for Library of Congress 93-47973


Copyright 1994 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America.

First Printing, April 1994

Second Printing, February 1996

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