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Veterans at Risk: The Health Effects of Mustard Gas and Lewisite (1993)
Institute of Medicine (IOM)

Page
24
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Veterans at Risk: The Health Effects of Mustard Gas and Lewisite

TABLE 3-1 Chemical and Physical Data

 

Sulfur Mustard

Lewisite

Nitrogen Mustard

Chemical Abstracts Registry Number

505-60-2

541-25-3

51-75-2

Chemical formula

C4H8Cl2S

C2H2AsCl3

C5H11Cl2N

Chemical structure

CH2-CH2Cl

H          AsCl2

CH2-CH2Cl

 

S

 

H3C-N

 

CH2-CH2Cl

Cl H

CH2-CH2Cl

Synonyms

1,1'-Thiobis(2-chloroethane); 2,2'-dichloroethyl sulfide; bis(2-chloroethyl) sulfide; ,'-dichloroethyl sulfide; mustard gas; Schwefel-Lost; S-Lost; Yperite; yellow cross; Senfgas; Kampstoff "Lost"; dichlorodiethyl sulfide

Chlorovinyldichloroarsine; 2-chlorovinyldichloroarsine; chlorovinylarsine dichloride; dichloro(2-chlorovinyl)arsine

Mechlorethamine; chlormethine; 2-chloro-N-(2-chloroethyl)-Nmethylethanamine; Stickstofflost; di(chloroethyl)methylamine

Abbreviations

H (Levinstein mustard), HD (distilled mustard), HT (impure mixture)

L

HN2; related compounds include HN1, ethylbis(chloroethyl)amine; and HN3, tris(-chloroethyl)amine

Melting point

13C-14C

0.1C

-60C

Boiling point

215C-217C at 760 mm Hg

190C at 760 mm Hg (decomposes)

87C at 18 Hg

Molecular weight

159.08

207.32

156.1

Solubility

Very sparingly soluble in water; soluble in oily solvents; high lipid solubility

Insoluble in water, soluble in ordinary organic solvents

Very slightly soluble in water

Appearance and odor

Colorless when pure, normally yellow to brown oily liquid, slight garlic-type odor

Liquid, faint odor of geranium

Liquid, faint fishy odor

 

SOURCES: Budavari, 1989; Hazardous Substances Databank, 1991; IARC, 1975; Somani, 1992; U.S. Army CRDEC, 1988, 1990.

Page
24
Front Matter (R1-R20)
Executive Summary (1-8)
1 Introduction (9-13)
2 Methods of Literature Collection and Survey (14-20)
3 History and Analysis of Mustard Agent and Lewisite Research Programs in the United States (21-60)
4 Findings from the Public Hearing Process (61-70)
5 Chemistry of Sulfur Mustard and Lewisite (71-80)
6 Relationship of Mustard Agent and Lewisite Exposure to Carcinogenesis (81-111)
7 Nonmalignant Respiratory Effects of Mustard Agents and Lewisite (112-130)
8 Ocular Effects of Mustard Agents and Lewisite (131-147)
9 Dermatological Effects of Mustard Agents and Lewisite (148-178)
10 Other Physiological Effects of Mustard Agents and Lewisite (179-198)
11 Relationship of Mustard Agent and Lewisite Exposure to Psychological Dysfunction (199-213)
12 Summary of Findings and Recommendations (214-226)
Bibliography (227-330)
A. Scientific and Background Presentations Made to the Committee (331-334)
B. Excerpt from The Residual Effects of Warfare Gases (335-337)
C. Involvement of the National Academy of Sciences Complex in World War II Research Programs: A Summary (338-339)
D. Excerpts from Chamber Tests with Human Subjects I, II, and IX. Naval Research Laboratory Reports Nos. P-2208 and P-2579 (340-369)
E. Interim Report and Addendum: Feasibility of Developing a Cohort of Veterans Exposed to Mustard Gas During WWII Testing Programs (370-377)
F. Summary of the Department of the Army Report: Use of Volunteers in Chemical Agent Research (378-381)
G. Public Hearing Announcement (382-385)
H. Letter from Dr. Jay Katz to Dr. David P. Rall (386-389)
I. Risk Assessment Considerations for Sulfur Mustard (390-398)
J. Examination of the Effects of Certain Acute Environmental Exposures on Future Respiratory Health Consequences (399-416)
List of Acronyms and Abbreviations (417-420)
Index (421-428)