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PAPERBACK list:$49.00 Web:$44.10 add to cart PDF BOOK your price: $37.50 add to cart Rights & Permissions Free Resources PDF EXECUTIVE SUMMARY Display this book on your site! Related Titles Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment Toxicity Testing for Assessment of Environmental Agents: Interim Report Other Related Titles Issues in Risk Assessment (1993) Commission on Life Sciences (CLS) Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Page 233   E-mail  Facebook  Digg  Stumble  Twitter More The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. Appendix B Workshop Program Thursday, November 8, 1990 8:30 Welcome: Donald Mattison, University of Pittsburgh Committee Vice-Chairman 8:35 Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman 8:45 Biological Factors in Two-Stage Models   Presenter: Alfred Knudson, Fox Chase Cancer Center 9:30 Discussant: Robert Maronpot, NIEHS 9:50 Questions and Comments 10:10 Break 10:30 Two-Stage Clonal Expansion Model of Carcinogenesis   Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center 11:15 Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc. 12:00 Questions and Comments Page 233 Front Matter (R1-R18) Executive Summary (1-12) Use of the Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity (13-14) 1 Introduction (15-20) 2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity (21-42) 3 Advantages and Disadvantages of Bioassys That Use the MTD (43-52) 4 Options Considered (53-60) 5 Conclusions and Recommendations (61-66) References (67-78) Appendix A: Workshop Summary - Maximum Tolerated Dose: Implications for Risk Assessment (79-90) Appendix B: Workshop Organizing Subcommittee (91-92) Appendix C: Workshop Federal Liaison Group (93-94) Appendix D: Workshop Programs (95-96) Appendix E: Workshop Attendees (97-110) Appendix F: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment (111-172) Appendix G: Informal Search for Supercarcinogens (173-184) The Two-Stage Model of Carcinogenesis (185-186) Issues in Risk Assessment (187-216) References (217-222) Appendix A: Workshop Summary - Two-Stage Modelsof Carcinogenesis (223-232) Appendix B: Workshop Program (233-234) Appendix C: Workshop Federal Liaison Group (235-236) Appendix D: Workshop Attendees (237-238) Appendix E: Workshop Organizing Task Group (239-240) A Paradigm for Ecological Risk Assessment (241-242) 1 Introduction (243-246) 2 Scope of Ecological Risk Assessment (247-248) 3 Revision of 1983 Framework to Incorporate Ecological Risk Assessment (249-258) 4 Key Scientific Problems Limiting Application of Ecological Risk Assessment (259-264) 5 Conclusions (265-266) 6 Recommendations (267-268) References (269-272) Appendix A: Workshop Participants (273-278) Appendix B: Workshop Organizing Subcommittee and Federal Liaison Group (279-280) Appendix C: Workshop Introduction (281-282) Appendix D: Opening Plenary Presentations (283-292) Appendix E: Case Studies and Commentaries (293-308) Appendix F: Breakout Sessions (309-336) Appendix G: Contemplations on Ecological Risk Assessment (337-342) Appendix H: Workshop Summary (343-346) Appendix I: References for Appendixes (347-350) Appendix J: Workshop Program (351-356)

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OCR for page 233
Issues in Risk Assessment Appendix B Workshop Program Thursday, November 8, 1990 8:30 Welcome: Donald Mattison, University of Pittsburgh Committee Vice-Chairman 8:35 Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman 8:45 Biological Factors in Two-Stage Models   Presenter: Alfred Knudson, Fox Chase Cancer Center 9:30 Discussant: Robert Maronpot, NIEHS 9:50 Questions and Comments 10:10 Break 10:30 Two-Stage Clonal Expansion Model of Carcinogenesis   Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center 11:15 Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc. 12:00 Questions and Comments

OCR for page 234
Issues in Risk Assessment 12:15 Lunch 1:15 Application of the Two-Stage Model to Animal Data   Presenter: Samuel Cohen, University of Nebraska Medical Center 2:00 Discussants: William Farland, EPA; Carl Barrett, NIEHS 2:30 Questions and Comments 2:45 General Discussion   Leader: Richard Griesemer, NIEHS   Issues:   • The scientific basis for two-stage models of carcinogenesis. • Can two-stage models of carcinogenesis adequately represent biological processes that may involve a variety of mechanisms? • The implications for the design of rodent bioassays. • The implications for health risk assessment. 3:30 Adjourn

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richard griesemer