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Issues in Risk Assessment (1993)
Commission on Life Sciences (CLS)

Page
239
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Issues in Risk Assessment

Appendix E
Workshop Organizing Task Group

Richard A. Griesemer (Chairman)

National Institute of Environmental Health Sciences

Research Triangle Park, NC

John C. Bailar, III

McGill University School of Medicine

Montreal, Canada

Paul T. Bailey

Mobil Oil Corporation

Princeton, NJ

Kenny S. Crump

Clement Associates, Inc.

Ruston, LA

Michael A. Gallo

University of Medicine and Dentistry of New Jersey

Piscataway, NJ

Daniel Krewski

Health and Welfare Canada

Ottawa, Ontario

Canada

Donald Mattison

University of Pittsburgh

Pittsburgh, PA

Franklin E. Mirer

United Auto Workers

Detroit, MI

D. Warner North

Decision Focus, Inc.

Mountain View, CA

Page
239
Front Matter (R1-R18)
Executive Summary (1-12)
Use of the Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity (13-14)
1 Introduction (15-20)
2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity (21-42)
3 Advantages and Disadvantages of Bioassys That Use the MTD (43-52)
4 Options Considered (53-60)
5 Conclusions and Recommendations (61-66)
References (67-78)
Appendix A: Workshop Summary - Maximum Tolerated Dose: Implications for Risk Assessment (79-90)
Appendix B: Workshop Organizing Subcommittee (91-92)
Appendix C: Workshop Federal Liaison Group (93-94)
Appendix D: Workshop Programs (95-96)
Appendix E: Workshop Attendees (97-110)
Appendix F: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment (111-172)
Appendix G: Informal Search for Supercarcinogens (173-184)
The Two-Stage Model of Carcinogenesis (185-186)
Issues in Risk Assessment (187-216)
References (217-222)
Appendix A: Workshop Summary - Two-Stage Modelsof Carcinogenesis (223-232)
Appendix B: Workshop Program (233-234)
Appendix C: Workshop Federal Liaison Group (235-236)
Appendix D: Workshop Attendees (237-238)
Appendix E: Workshop Organizing Task Group (239-240)
A Paradigm for Ecological Risk Assessment (241-242)
1 Introduction (243-246)
2 Scope of Ecological Risk Assessment (247-248)
3 Revision of 1983 Framework to Incorporate Ecological Risk Assessment (249-258)
4 Key Scientific Problems Limiting Application of Ecological Risk Assessment (259-264)
5 Conclusions (265-266)
6 Recommendations (267-268)
References (269-272)
Appendix A: Workshop Participants (273-278)
Appendix B: Workshop Organizing Subcommittee and Federal Liaison Group (279-280)
Appendix C: Workshop Introduction (281-282)
Appendix D: Opening Plenary Presentations (283-292)
Appendix E: Case Studies and Commentaries (293-308)
Appendix F: Breakout Sessions (309-336)
Appendix G: Contemplations on Ecological Risk Assessment (337-342)
Appendix H: Workshop Summary (343-346)
Appendix I: References for Appendixes (347-350)
Appendix J: Workshop Program (351-356)

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OCR for page 239
Issues in Risk Assessment Appendix E Workshop Organizing Task Group Richard A. Griesemer (Chairman) National Institute of Environmental Health Sciences Research Triangle Park, NC John C. Bailar, III McGill University School of Medicine Montreal, Canada Paul T. Bailey Mobil Oil Corporation Princeton, NJ Kenny S. Crump Clement Associates, Inc. Ruston, LA Michael A. Gallo University of Medicine and Dentistry of New Jersey Piscataway, NJ Daniel Krewski Health and Welfare Canada Ottawa, Ontario Canada Donald Mattison University of Pittsburgh Pittsburgh, PA Franklin E. Mirer United Auto Workers Detroit, MI D. Warner North Decision Focus, Inc. Mountain View, CA

OCR for page 240
Issues in Risk Assessment This page in the original is blank.

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sciences mcgill