Items in cart [0] Questions? Call 888-624-8373

PAPERBACK list:$49.00 Web:$44.10 add to cart PDF BOOK your price: $37.50 add to cart Rights & Permissions Free Resources PDF EXECUTIVE SUMMARY Display this book on your site! Related Titles Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment Toxicity Testing for Assessment of Environmental Agents: Interim Report Other Related Titles Issues in Risk Assessment (1993) Commission on Life Sciences (CLS) Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Page 97   E-mail  Facebook  Digg  Stumble  Twitter More The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. Appendix E Workshop Attendees Dr. Philip H. Abelson AAAS Washington, DC Dr. Bruce Ames University of California, Berkeley Berkeley, CA Dr. Alexander Apostolou U.S. Food and Drug Administration Rockville, MD Dr. Gail T. Arce Alochem North America Agrochemicals Division Philadelphia, PA Dr. Debra Aub U.S. Food and Drug Administration Rockville, MD Dr. Karl Baetcke U.S. Environmental Protection Agency Washington, DC Dr. Paul T. Bailey Mobil Oil Corporation Princeton, NJ Mr. Robert C. Barnard Cleary, Gottlieb, Steen and Hamilton Washington, DC Dr. Karam Batra U.S. Food and Drug Administration Rockville, MD Mr. Gregory Bendlin Cameron & Hornbostel Washington, DC Page 97 Front Matter (R1-R18) Executive Summary (1-12) Use of the Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity (13-14) 1 Introduction (15-20) 2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity (21-42) 3 Advantages and Disadvantages of Bioassys That Use the MTD (43-52) 4 Options Considered (53-60) 5 Conclusions and Recommendations (61-66) References (67-78) Appendix A: Workshop Summary - Maximum Tolerated Dose: Implications for Risk Assessment (79-90) Appendix B: Workshop Organizing Subcommittee (91-92) Appendix C: Workshop Federal Liaison Group (93-94) Appendix D: Workshop Programs (95-96) Appendix E: Workshop Attendees (97-110) Appendix F: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment (111-172) Appendix G: Informal Search for Supercarcinogens (173-184) The Two-Stage Model of Carcinogenesis (185-186) Issues in Risk Assessment (187-216) References (217-222) Appendix A: Workshop Summary - Two-Stage Modelsof Carcinogenesis (223-232) Appendix B: Workshop Program (233-234) Appendix C: Workshop Federal Liaison Group (235-236) Appendix D: Workshop Attendees (237-238) Appendix E: Workshop Organizing Task Group (239-240) A Paradigm for Ecological Risk Assessment (241-242) 1 Introduction (243-246) 2 Scope of Ecological Risk Assessment (247-248) 3 Revision of 1983 Framework to Incorporate Ecological Risk Assessment (249-258) 4 Key Scientific Problems Limiting Application of Ecological Risk Assessment (259-264) 5 Conclusions (265-266) 6 Recommendations (267-268) References (269-272) Appendix A: Workshop Participants (273-278) Appendix B: Workshop Organizing Subcommittee and Federal Liaison Group (279-280) Appendix C: Workshop Introduction (281-282) Appendix D: Opening Plenary Presentations (283-292) Appendix E: Case Studies and Commentaries (293-308) Appendix F: Breakout Sessions (309-336) Appendix G: Contemplations on Ecological Risk Assessment (337-342) Appendix H: Workshop Summary (343-346) Appendix I: References for Appendixes (347-350) Appendix J: Workshop Program (351-356)

Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 97
Issues in Risk Assessment Appendix E Workshop Attendees Dr. Philip H. Abelson AAAS Washington, DC Dr. Bruce Ames University of California, Berkeley Berkeley, CA Dr. Alexander Apostolou U.S. Food and Drug Administration Rockville, MD Dr. Gail T. Arce Alochem North America Agrochemicals Division Philadelphia, PA Dr. Debra Aub U.S. Food and Drug Administration Rockville, MD Dr. Karl Baetcke U.S. Environmental Protection Agency Washington, DC Dr. Paul T. Bailey Mobil Oil Corporation Princeton, NJ Mr. Robert C. Barnard Cleary, Gottlieb, Steen and Hamilton Washington, DC Dr. Karam Batra U.S. Food and Drug Administration Rockville, MD Mr. Gregory Bendlin Cameron & Hornbostel Washington, DC

OCR for page 98
Issues in Risk Assessment Dr. Jeff Beaubier U.S. Environmental Protection Agency Washington, DC Ms. Michele Beguhn ICI Americas Wilmington, DE Dr. Judith Bellin Washington, DC Mr. Keith Belton American Chemical Society Washington, DC Dr. Richard Belzer Office of Management and Budget Washington, DC David Bergsten U.S. Department of Agriculture Hyattsville, MD Dr. Sanford W. Bigelow National Research Council Washington, DC Ms. Nathalie Blackwell Ketchum Communications Washington, DC Dr. Charles Blank American Petroleum Institute Washington, DC Dr. Charles Breckenridge CIBA GEIGY Corporation Greensboro, NC Dr. E. Anne Brown U.S. Department of Agriculture Washington, DC Dr. Robert Brown U.S. Food and Drug Administration Washington, DC Dr. Gary Burin Falls Church, VA Dr. William Burman U.S. Environmental Protection Agency Washington, DC Dr. Dorothy Canter National Institute of Environmental Health Sciences Bethesda, MD Dr. Raymond Cardona Uniroyal Chemical Company Bethany, CT Dr. Charles J. Carr Scientific Information Associates Columbia, MD

OCR for page 99
Issues in Risk Assessment Dr. Chia Chen U.S. Department of Labor/OSHA Washington, DC Dr. Paul Chin U.S. Environmental Protection Agency Washington, DC Dr. Arthur Chiu U.S. Environmental Protection Agency Washington, DC Dr. Young S. Choi U.S. Food and Drug Administration Rockville, MD Dr. Misoon Chun Cabin John, MD Mr. Dan Charles New Scientist Washington, DC Dr. William Cibulas Agency for Toxic Substances and Disease Registry Atlanta, GA Mr. Steve Clapp Food Chemical News Washington, DC Mr. David Clark Inside EPA Weekly Report Arlington, VA Dr. Ann Clevenger U.S. Environmental Protection Agency Washington, DC Dr. Rory Conolly Chemical Industrial Institute of Toxicology Research Triangle Park, NC Dr. Joseph Contrera U.S. Food and Drug Administration Rockville, MD Mr. Robert A. Coppock National Research Council Washington, DC Dr. Edmund Crouch Cambridge Environmental Cambridge, MA Dr. Kenny S. Crump Clement Associates, Inc. Ruston, LA Dr. Cynthia Cunard U.S. Food and Drug Administration Rockville, MD

OCR for page 100
Issues in Risk Assessment Dr. Miriam Davis National Institute of Environmental Health Sciences/NTP National Institutes of Health Bethesda, MD Dr. Richard A. Davis American Cyanamid Company Wayne, NJ Ms. Kelly Day U.S. Department of Agriculture Washington, DC Dr. Kerry Dearfield U.S. Environmental Protection Agency Washington, DC Mr. Charles L. Divan Environmental Documentation Hyattsville, MD Dr. John Doherty U.S. Environmental Protection Agency Washington, DC Dr. John Doull University of Kansas Medical Center Kansas City, KS Mr. Robert Drew American Petroleum Institute Washington, DC Dr. Julie Du U.S. Environmental Protection Agency Washington, DC Dr. Ronald J. Dutton International Life Sciences Institute Washington, DC Dr. Gerard Egan Exxon Biomedical Sciences, Inc. East Millstone, NJ Dr. Reto Engler U.S. Environmental Protection Agency Washington, DC Dr. John L. Emmerson Lilly Research Laboratories Eli Lilly and Company Greenfield, IN Dr. William H. Farland U.S. Environmental Protection Agency Washington, DC Mr. Conner M. Fay Clairol, Inc. New York, NY Dr. Penelope Fenner-Crisp U.S. Environmental Protection Agency Washington, DC

OCR for page 101
Issues in Risk Assessment Ms. Bernice Fisher U.S. Environmental Protection Agency Washington, DC Dr. Glenna Fitzgerald Silver Spring, MD Ms. Caroline Freeman U.S. Department of Labor/OSHA Washington, DC Dr. Tom Fuhremann Monsanto Agricultural Company St. Louis, MO Ms. Carolyn Fulco Department of Human and Health Services Washington, DC Dr. Victor Fung National Institute of Environmental Health Sciences Bethesda, MD Dr. Wing Fung Unilever Research Edgewater, NJ Dr. Michael A. Gallo Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey Piscataway, NJ Mr. Hank Gardner U.S. Army Frederick, MD Dr. David Gaylor National Center for Toxicological Research Jefferson, AR Dr. Herman Gibb U.S. Environmental Protection Agency Washington, DC Dr. Walter H. Glinsmann U.S. Food and Drug Administration Washington, DC Dr. Anwar Goheer U.S. Food and Drug Administration Rockville, MD Dr. Bernard D. Goldstein Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey Piscataway, NJ Dr. Thomas Goldsworthy Chemical Industrial Institute of Toxicology Research Triangle Park, NC

OCR for page 102
Issues in Risk Assessment Dr. Michael Gough Center for Risk Management Resources for the Future Washington, DC Dr. Martin Greene U.S. Food and Drug Administration Rockville, MD Dr. Richard A. Griesemer National Institute of Environmental Health Sciences Research Triangle Park, NC Dr. Stanley B. Gross U.S. Environmental Protection Agency Washington, DC Ms. Elizabeth Grossman U.S. Department of Labor/OSHA Washington, DC Dr. William E. Halperin National Institute for Occupational Safety and Health Cincinnati, OH Dr. Bryan D. Hardin National Institute for Occupational Safety and Health Cincinnati, OH Dr. Jane Harris American Cyanamid Company Princeton, NJ Dr. Dale Hattis Center for Technology, Policy, and Industrial Development Massachusetts Institute of Technology Cambridge, MA Mr. Fred Hauchman U.S. Environmental Protection Agency Research Triangle Park, NC Dr. Rogene Henderson Lovelace Biomedical and Environmental Research Institute Albuquerque, NM Dr. Bernhard Hildebrand BASF AG Ludwigshafen West Germany Dr. Fred D. Hoerger The Dow Chemical Company Midland, MI Dr. Karen Hogan U.S. Environmental Protection Agency Washington, DC Mr. Stewart Holm Halogenated Solvents Industry Alliance Washington, DC

OCR for page 103
Issues in Risk Assessment Dr. Charlie Hremat U.S. Environmental Protection Agency Washington, DC Dr. James Huff National Institute of Environmental Health Sciences Research Triangle Park, NC Dr. Donald Hughes Procter & Gamble Company Cincinnati, OH Dr. Peter Infante U.S. Department of Labor/OSHA Washington, DC Dr. Carol Jones U.S. Department of Labor/OSHA Washington, DC Dr. Dennis E. Jones Agency for Toxic Substances and Disease Registry Atlanta, GA Dr. Alexander Jordan U.S. Food and Drug Administration Rockville, MD Dr. A. Michael Kaplan Haskell Laboratory E.I. duPont de Nemours & Co. Newark, DE Dr. Myra Karstadt National Institue of Environmental Health Sciences Bethesda, MD Mr. William Kelly Federal Focus, Inc. Washington, DC Dr. Krishan Khanna U.S. Environmental Protection Agency Washington, DC Ms. Leslie J. King Chemical Manufacturers Association Washington, DC Mr. William A. Kittrell Karch & Associates, Inc. Washington, DC Ms. Gina Kolata New York Times New York, NY Dr. Albert C. Kolbye Kolbye Associates Bethesda, MD

OCR for page 104
Issues in Risk Assessment Ms. Christine Kopral U.S. Food and Drug Administration Washington, DC Dr. Richard Krasula Abbott Laboratories Abbott Park, IL Dr. Daniel Krewski Health and Welfare Canada Ottawa, Ontario Canada Dr. Betsy Kuhn U.S. Department of Agriculture Washington, DC Dr. David Lai U.S. Environmental Protection Agency Washington, DC Dr. Brian P. Leaderer John B. Pierce Foundation Yale University School of Medicine New Haven, CT Mr. Arnold H. Leibowitz Cameron & Hornbostel Washington, DC Ms. Linda V. Leonard National Research Council Washington, DC Dr. David Lien U.S. Environmental Protection Agency Washington, DC Dr. Bertam Litt Litt Associates Washington, DC Dr. Janice Longstreth Battelle Pacific NW Washington, DC Dr. Ronald J. Lorentzen U.S. Food and Drug Administration Washington, DC Dr. Carol Maczka Clement Associates Fairfax, VA Dr. Amal Mahfouz U.S. Environmental Protection Agency Washington, DC Dr. Elizabeth Margosches U.S. Environmental Protection Agency Washington, DC Dr. Donald Mattison Graduate School of Public Health University of Pittsburgh Pittsburgh, PA

OCR for page 105
Issues in Risk Assessment Dr. John F. McCarthy National Agricultural Chemicals Association Washington, DC Dr. R. Michael McClain Hoffmann LaRoche, Inc. Nutley, NJ Ernest E. McConnell, DVM Raleigh, NC Dr. Lawrence McCray National Research Council Washington, DC Dr. James McDermott Procter and Gamble Company Cincinnati, OH Dr. John Melagrana U.S. Food and Drug Administration Rockville, MD Dr. Frances Mielach U.S. Food and Drug Administration Rockville, MD Dr. Franklin E. Mirer United Auto Workers Detroit, MI Dr. Lakshmi Mishra Consumer Product Safety Commission Bethesda, MD Dr. Alastair Monro Phizer Central Research Groton, CT Dr. Ian C. Munro Canadian Centre for Toxicology University of Guelph Guelph, Ontario CANADA Mr. Leonard Nessen U.S. Food and Drug Administration Rockville, MD Dr. Daniel W. Nebert Institute of Environmental Health University of Cincinnati Medical Center The Kettering Laboratory Cincinnati, OH Dr. Thoa Nguyen U.S. Environmental Protection Agency Washington, DC Dr. Ian Nisbet I.C.T. Nisbet & Company, Inc. Lincoln, MA Dr. D. Warner North Decision Focus, Inc. Mountain View, CA

OCR for page 106
Issues in Risk Assessment Ms. Carolyn Nunley ERM Exton, PA Dr. Clyde Oberlander U.S. Food and Drug Administration Rockville, MD Dr. Edward Ohanian U.S. Environmental Protection Agency Washington, DC Dr. Gilbert S. Omenn School of Public Medicine and Community Medicine University of Washington Seattle, WA Mr. Richard Orr U.S. Department of Agriculture Hyattville, MD Dr. Robert Osterberg U.S. Food and Drug Administration Rockville, MD Ms. Carol O'Toole American Industrial Health Council Washington, DC Dr. Richard Parry, Jr. U.S. Department of Agriculture Beltsville, MD Dr. Yogen Patel U.S. Environmental Protection Agency Washington, DC Dr. Dorothy Patton U.S. Environmental Protection Agency Washington, DC Dr. Mary B. Paxton National Research Council Washington, DC Dr. William Pepelko U.S. Environmental Protection Agency Washington, DC Mr. Hugh Pettigrew U.S. Environmental Protection Agency Washington, DC Dr. Peter Preuss U.S. Environmental Protection Agency Washington, DC Dr. Richard H. Reitz The Dow Chemical Company Midland, MI

OCR for page 107
Issues in Risk Assessment Dr. Esther Rinde U.S. Environmental Protection Agency Washington, DC Major Welford Roberts U.S. Environmental Protection Agency Washington, DC Dr. Barry Rosloff U.S. Food and Drug Administration Rockville, MD Dr. James Rowe U.S. Environmental Protection Agency Washington, DC Dr. Matthew H. Royer U.S. Department of Agriculture Hyattsville, MD Dr. Manfred Ruthsatz U.S. Food and Drug Administration Rockville, MD Dr. Lilly Sanathanan U.S. Food and Drug Administration Rockville, MD Dr. Robert Scheuplein U.S. Food and Drug Administration Washington, DC Dr. Rita Schoeny U.S. Environmental Protection Agency Cincinnati, OH Dr. Loretta Schuman U.S. Department of Labor/OSHA Washington, DC Dr. Robert L. Sielken, Jr. Sielken Incorporated Bryan, TX Mr. Fred Siskind U.S. Department of Labor Washington, DC Dr. Jerry M. Smith Rohm & Haas Company Philadelphia, PA Dr. Jill Snowdon United Fresh Fruit and Vegetable Association Alexandria, VA Ms. Susan Snyder American Paper Institute Washington, DC

OCR for page 108
Issues in Risk Assessment Mr. Hugh Spitzer American Petroleum Institute Washington, DC Ms. Anne Sprague National Research Council Washington, DC Ms. Janet A. Springer U.S. Food and Drug Administration Washington, DC Dr. Thomas B. Starr ENVIRON Corporation Arlington, VA9 Dr. Leslie T. Stayner National Institute for Occupational Safety and Health Cincinnati, OH Dr. Bonnie R. Stern U.S. Environmental Protection Agency Washington, DC Ms. Jennifer Sutton Association of American Medical Colleges Washington, DC Dr. Alan Taylor U.S. Food and Drug Administration Rockville, MD Ms. Alison Taylor Harvard School of Public Health Boston, MA Dr. Richard D. Thomas National Research Council Washington, DC Ms. Sarah Thurin BNA Washington, DC Dr. John J. Tice Georgia Pacific Washington, DC Dr. Lorna C. Totman Nonprescription Drug Manufacturers Association Washington, DC Dr. Curtis C. Travis Oak Ridge National Laboratories Oak Ridge, TN Dr. Marsha Van Gemert U.S. Environmental Protection Agency Washington, DC Dr. Ron Van Mynen Chemical and Plastics Group Union Carbide Corporation Danbury, CT

OCR for page 109
Issues in Risk Assessment Dr. Andrea A. Wargo Agency for Toxic Substances and Disease Registry Washington, DC Dr. Judy Weissinger U.S. Food and Drug Administration Rockville, MD Dr. Bob West Food, Drug, Chemical Services Fairfax, VA Dr. John Whysner American Health Foundation Valhalla, NY Dr. James Wilson U.S. Food and Drug Administration Rockville, MD Dr. James D. Wilson Monsanto St. Louis, MO Dr. Lucy Yu U.S. Food and Drug Administration Rockville, MD Dr. Lauren Zeise California Department of Health Services Berkeley, CA

OCR for page 110
Issues in Risk Assessment This page in the original is blank.

Representative terms from entire chapter:

gamble company