Reference

Relationship to Recipient

Immune Deficiency or History of Polio Immunization in Contact

Adams et al., 1977

31-yr-old mother of infant

Depressed T-cell function

Orzechowska-Wolczyk et al., 1976

25-yr-old mother of child

No information

Wilson and Robinson, 1974

4-mo-old contact of infant

Unimmunized

Kostrzewski, 1973

Six children in group care

No information

Haneberg and Orstavik, 1972

1-yr-old younger brother of 10-yr-old recipient

Unimmunized

Kuwert et al., 1971

48-yr-old grandmother

No information

Riker et al., 1971

8-mo-old sibling of a recipient

Probable hereditary thymic dysplasia

Stolley et al., 1968

16-mo-old cousin of recipient

Probable hypogammaglobulinemia, unimmunized

Balduzzi and Glasgow, 1967

5-yr-old classmate of recipient

Had received four doses of Salk vaccine and one dose of type 2 Sabin vaccine

Swanson et al., 1967

29-yr-old father of 2-yr-old

Unimmunized

Morse et al., 1966

43-yr-old mother of infant

Unimmunized

Case Reports, Case Series, and Uncontrolled Observational Studies

Table 7-5 summarizes the three cases of transverse myelitis that have been reported in the literature to occur following vaccination with OPV. Two cases occurred in infants. A seven-month old girl developed symptoms 6 days after receiving OPV and diphtheria and tetanus toxoids (DT) (Whittle and Roberton, 1977). A 20-month girl developed symptoms 1 month after receiving OPV and diphtheria and tetanus toxoids and pertussis vaccine (DPT). She was found to be hypogammaglobulinemic (Douglas and Anolik, 1981). The third case occurred in a 24-year-old woman who was simultaneously vaccinated with OPV and typhoid and cholera vaccines (D'Costa et al., 1990). The woman had a fever at the time of vaccination and had an upper respiratory tract infection and pharyngitis for the 5 weeks preceding vaccination. The committee is aware of a case of transverse myelitis in a child with severe combined immunodeficiency syndrome (Richard B. Johnston, Yale University, New Haven, personal communication, 1993). Vaccine-strain poliovirus was isolated from the myocardium. VAERS listed two cases (submitted between November 1990 and July 1992) of transverse myelitis that occurred in patients after receiving a combination



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement