studies provides evidence for a causal relation that outweighs the evidence against such a relation. Demonstrated biologic plausibility was considered supportive of a decision to accept a causal relation but insufficient on its own to shift the balance of evidence from other sources.

5. The evidence establishes a causal relation.

Epidemiologic studies and/or case reports provide unequivocal evidence for a causal relation, and biologic plausibility has been demonstrated.


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