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Environmental Medicine: Integrating a Missing Element into Medical Education (1995)
Institute of Medicine (IOM)

Page
167
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Environmental Medicine: Integrating a Missing Element into Medical Education

Sources of environmental arsenic include smelters, electric power plants using arsenic-rich coal, and soil and water found in certain parts of the world.18

Human poisoning from the burning of CCA-impregnated wood has not been previously reported and represents the probable source of arsenic exposure in this family. Fowler18 warned in 1977 that the burning of CCA-treated wood should be studied as a potential health hazard. Our studies of the kitchen-living area were done in the summer and disclosed notable contamination with CCA-rich ash. In the winter months while the CCA-treated plywood was being burned, we would have anticipated even greater contamination. With the increased popularity of burning wood for household heating purposes, the environmental health hazard of burning CCA-treated wood needs recognition and evaluation. The role of chromium and copper in contributing to these health problems is conjectural. We would suggest that all three elements could be responsible for this kaleidoscopic clinical pattern.

Joy Savides Felker provided advice and secretarial aid and Lee Sjouik, MS, contributed technical assistance.

References

1. Oettingen WF: Poisoning—A Guide to Clinical Diagnosis and Treatment, ed 2. Philadelphia, WB Saunders Co, 1958, pp 239–242.

2. Woolson E, Ahronson N: Separation and detection of arsenicals pesticides residues and some of their metabolites by high pressure liquid chromatography-graphite furnace atomic absorption spectro. J Assoc Off Anal Chem 1980;63:523–528.

3. Boylen GW, Hardy NL: Distribution of arsenic in nonexposed persons (hair, liver, and urine). Am Ind Hyg Assoc J 1967;28:148–150.

4. Mees RA: The nails with arsenical polyneuritis. JAMA 1919;72:1337.

5. Biologic and economic assessment of pentachlorophenol inorganic arsenicals, and creosote, in Wood Preservatives, Technical Bulletin No. 1658–1, US Dept of Agriculture, 1980, vol 1, pp 31–192.

6. Tseng WP: Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic. Environ Health Perspect 1977; 19:109–119.

7. Stewart CP, Stolman A: Toxicology—Mechanisms and Analytical Methods. New York, Academic Press Inc, 1960, vol 1, pp 202–206.

8. Moeschlin S: Poisoning—Diagnosis and Treatment New York, Grune & Stratton Inc, 1965, pp 162–169.

9. Creason JP, Hinners TA, Bumgarner SE, et al: Trace elements in hair as related to exposure in metropolitan New York. Clin Chem 1975; 21:603–612.

10. Harrison WW, Yurachek JP, Benson CA: The determination of trace elements in human hair by atomic absorption spectroscopy. Clin Chim Acta 1969;23:83–91.

11. Harrison WW, Clemena GG: Survey analysis of trace elements in human fingernails by spark source mass spectrometry. Clin Chim Acta 1971;36:485–492.

12. Harrison WW, Tyree AB: The determination of trace elements in human fingernails by atomic absorption spectroscopy. Clin Chim Acta 1971;31:63–73.

13. Casarett LJ, Doull J: The Basic Science of Poisons Toxicology. New York, Macmillan Publishing Co Inc, 1975, pp 464–465.

14. Ginsburg JM: Renal mechanism for excretion and transformation of arsenic in the dog. Am J Physiol 1965;208:832–840.

15. Feldman RG, Niles CA, Kelly-Hayes M, et al: Peripheral neuropathy in arsenic smelter workers. Neurology 1979;29:939–944.

16. International Agency for Research on Cancer (IARC): Arsenic and Arsenic Compounds, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Lyon, France, World Health Organization, IRAC, vol 23, pp 39–141.

17. Woolson EA: Fate of arsenicals in different environmental substrates. Environ Health Perspect 1977;19:73–81.

18. Fowler BA: International conference on environmental arsenic: An overview. Environ Health Perspect 1977;19:239–242.

Page
167
Front Matter (R1-R12)
Executive Summary (1-4)
1 Introduction (5-13)
2 Curriculum Content (14-21)
3 Implementation Strategies (22-43)
4 Changing Medical Education (44-51)
5 Concluding Remarks (52-53)
References (54-58)
Appendixes (59-60)
A: Taking an Exposure History (61-96)
B: Medical School Courses and Clerkships: Access Points for Integrating Environmental Medicine (97-120)
C: Case Studies in Environmental Medicine (121-138)
Case Study 1: Arsenic Toxicity (139-163)
Case Study 2: Seasonal Arsenic Exposure from Burning Chromium-Copper-Arsenate-Treated Wood (164-167)
Case Study 3: Asbestos Toxicity (168-188)
Case Study 4: Benzene Toxicity (189-207)
Case Study 5: Beryllium Toxicity (208-223)
Case Study 6: Cadmium Toxicity (224-243)
Case Study 7: Fetal Death Due to Nonlethal Maternal Carbon Monoxide Poisoning (244-248)
Case Study 8: Carbon Tetrachloride Toxicity (249-266)
Case Study 9: Chlordane Toxicity (267-288)
Case Study 10: Chronic Reactive Airway Disease Following Acute Chlorine Gas Exposure in an Asymptomatic Atopic Patient (289-290)
Case Study 11: Chromium Toxicity (291-311)
Case Study 12: Cyanide Toxicity (312-331)
Case Study 13: Dioxin Toxicity (332-348)
Case Study 14: Ethylene/Propylene Glycol Toxicity (349-371)
Case Study 15: Formalin Asthma in Hospital Staff (372-373)
Case Study 16: Gasoline Toxicity (374-394)
Case Study 17: Hantavirus Pulmonary Syndrome: A Clinical Description of 17 Patients with a Newly Recognized Disease (395-401)
Case Study 18: Lead Poisoning from Mobilization of Bone Stores During Thyrotoxicosis (402-409)
Case Study 19: Lead Toxicity (410-435)
Case Study 20: Legionaires' Disease: Description of an Epidemic of Pneumonia (436-444)
Case Study 21: Mercury in House Paint as a Cause of Acrodynia: Effect of Therapy with N-Acetyl-D, L-Penixillamine (445-449)
Case Study 22: Mercury Toxicity (450-472)
Case Study 23: Methanol Toxicity (473-492)
Case Study 24: Methylene Chloride Toxicity (493-511)
Case Study 25: Paint Remover Hazard (512-515)
Case Study 26: Fatal Outcome of Methemoglobinemia in an Infant (516-517)
Case Study 27: Nitrate/Nitrite Toxicity (518-537)
Case Study 28: An Outbreak of Nitrogen Dioxide-Induced Respiratory Illness Among Ice Hockey Players (538-541)
Case Study 29: Pentachlorophenol Toxicity (542-557)
Case Study 30: Aldicarb Poisoning: A Case Report with Prolonged Cholinesterase Inhibition and Improvement After Pralidoxime Therapy (558-561)
Case Study 31: Cholinesterase-Inhibiting Pesticide Toxicity (562-584)
Case Study 32: Infertility in Male Pesticide Workers (585-587)
Case Study 33: Pesticide Food Poisoning from Contaminated Watermelons in California, 1985 (588-595)
Case Study 34: Poisoning of an Urban Family Due to Misapplication of Household Organophosphate and Carbamate Pesticides (596-604)
Case Study 35: Polynuclear Aromatic Hydrocarbon (PAH) Toxicity (605-621)
Case Study 36: Polychlorinated Biphenyl (PCB) Toxicity (622-638)
Case Study 37: Ionizing Radiation (639-673)
Case Study 38: Radon Toxicity (674-694)
Case Study 39: Residential Radon Exposure and Lung Cancer in Sweden (695-700)
Case Study 40: Community Oubreaks of Asthma Associated with Inhalation of Soybean Dust (701-706)
Case Study 41: Tetrachloroethylene Toxicity (707-726)
Case Study 42: Toluene Toxicity (727-743)
Case Study 43: Occupational Asthma Due to Toluene Diisocyanate Among Velcro-like Tape Manufacturers (744-749)
Case Study 44: 1,1,1-Trichloroethane (750-766)
Case Study 45: Trimethyltin Encephalopathy (767-771)
Case Study 46: Trichloroethylene Toxicity (772-792)
Case Study 47: Vinyl Chloride Toxicity (793-811)
Case Study 48: Work-Related Disorders of the Neck and Upper Extremity (812-813)
Case Study 49: Contact Dermatitis in Surgeons from Methylmethacrylate Bone Cement (814-816)
Case Study 50: Skin Lesions and Environmental Exposures: Rash Decisions (817-861)
Case Study 51: Acoustic Trauma Caused by the Telephone: A Report of Two Cases (862-867)
Case Study 52: Behavioral and Audiologic Manifestations of Noise-Induced Hearing Loss (868-871)
Case Study 53: Reproductive and Developmental Hazards (872-892)
Case Study 54: Childhood Asthma and Indoor Enviromental Risk Factors (893-903)
Case Study 55: Populations at Risk From Particulate Air Pollution - United States, 1992 (904-908)
D: Resources: Agencies, Organizations, Services, REferences, and Tables of Environmental Health Hazards (909-970)
E: Committee and Staff Biographies (971-975)