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Prudent Practices in the Laboratory: Handling and Disposal of Chemicals
Flammability and Explosibility
Acetone is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Acetone vapor forms explosive mixtures with air at concentrations of 2 to 13% (by volume). Carbon dioxide or dry chemical extinguishers should be used for acetone fires.
Reactivity and Incompatibility
Fires and/or explosions may result from the reaction of acetone with strong oxidizing agents (e.g., chromium trioxide) and very strong bases (e.g., potassium t-butoxide).
Storage and Handling
Acetone should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C, supplemented by the additional precautions for dealing with extremely flammable substances (Chapter 5.F). In particular, acetone should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.
In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally) and obtain medical attention. If acetone is ingested, obtain medical attention immediately. If large amounts of this compound are inhaled, move the person to fresh air and seek medical attention at once.
In the event of a spill, remove all ignition sources, soak up the acetone with a spill pillow or absorbent material, place in an appropriate container, and dispose of properly. Respiratory protection may be necessary in the event of a large spill or release in a confined area.
Excess acetone and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines. For more information on disposal procedures, see Chapter 7 of this volume.