LABORATORY CHEMICAL SAFETY SUMMARY: ACROLEIN

Substance

Acrolein

(Acrylaldehyde, acrylic aldehyde, 2-propenal)

CAS 107-02-8

 

Formula

H2C = CHCHO

 

Physical Properties

Colorless to yellow liquid

bp 53 °C, mp -87 °C

Highly soluble in water (21 g/100 mL)

 

Odor

Pungent, lacrimatory, intensely irritating odor detectable at 0.02 to 0.4 ppm

Vapor Density

1.9 (air = 1.0)

 

Vapor Pressure

210 mmHg at 20 °C

 

Flash Point

-26 °C

 

Autoignition Temperature

234 °C

 

Toxicity Data

LD50 oral (rat)

42 to 46 mg/kg

 

LD50 skin (rabbit)

562 mg/kg

 

LC50 inhal (rat)

300 mg/m3(30 min)

 

PEL (OSHA)

0.1 ppm (0.25 mg/m3)

 

STEL (OSHA)

0.3 ppm (0.69 mg/m3)

 

TLV-TWA (ACGIH)

0.1 ppm (0.23 mg/m3)

 

STEL (ACGIH)

0.3 ppm (0.69 mg/m3)

Major Hazards

Highly toxic; causes severe irritation and corrosion of skin, eyes, nose, and respiratory system; highly flammable; may polymerize violently upon loss or removal of inhibitor or initiation by chemical agents.

Toxicity

Acrolein is a highly toxic and corrosive substance. Inhalation of acrolein can cause moderate to severe eye, nose, and respiratory system irritation after a few minutes of exposure to concentrations as low as 0.25 ppm. Higher concentrations can cause immediate and/ or delayed lung injury including pulmonary edema and respiratory insufficiency; fatal reactions have occurred upon exposure to as little as 10 ppm. This substance is a powerful lacrimator, and eye contact with acrolein liquid or vapor can cause severe burns. Skin contact can cause severe redness, swelling, burns with blistering, and corrosion. Acrolein can be absorbed through the skin, leading to systemic effects including delayed pulmonary edema. Ingestion of acrolein can cause gastrointestinal distress, pulmonary congestion, and edema. Acrolein has been reported to be a weak skin sensitizer in some individuals. This substance is regarded as having adequate warning properties.



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