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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. sumably from millipedes. The sources of other alkaloids in amphibian skin, including the batrachotoxins, the decahydroquinolines, the histrionicotoxins, the pumiliotoxins, and epibatidine, are unknown. While it is possible that these are produced de novo or by symbiotic microorganisms, it appears more likely that they are sequestered by the amphibians from as yet unknown dietary sources. REFERENCES1. Whittaker, R. H. & Feeny, P. P. (1971) Science 171, 757-770. 2. Balandrin, M. F., Klocke, J. A., Wurtele, E. S. & Bollinger, W. H. (1985) Science 228, 1154-1160. 3. Scheuer, P. J. (1990) Science 248, 173-177. 4. Yasumoto, T. & Murata, M. (1993) Chem. Rev. 93, 1897-1909. 5. Eisner, T. & Meinwald, J. (1966) Science 153, 1341-1350. 6. Jones, T. H. & Blum, M. S. (1983) Alkaloids: Chemical and Biological Perspectives (Wiley, New York), Vol. 1, pp. 33-84. 7. Tachibana, K. (1988) Bioorg. Mar. Chem. 2, 124-145. 8. Daly, J. W., Myers, C. W. & Whittaker, N. (1987) Toxicon 25, 1023-1095. 9. Dumbacher, J. P., Beehler, B. M., Spande, T. F., Garraffo, H. M. & Daly, J. W. (1992) Science 258, 799-801. 10. Erspamer, V., Melchiorri, P., Erspamer, G. F., Montecucchi, P. C. & De Castiglione, R. (1985) Peptides 6, 7-12. 11. Flier, J., Edwards, M. W., Daly, J. W. & Myers, C. W. (1980) Science 208, 503-505. 12. Daly, J. W., Gusovsky, F., Myers, C. W., Yotsu-Yamashita, M. & Yasumoto, T. (1994) Toxicon 32, 279-285. 13. Bevins, C. L. & Zasloff, M. (1990) Annu. Rev. Biochem. 59, 395-414. 14. Daly, J. W., Caceres, J., Moni, R. W., Gusovsky, F., Moos, M., Jr., Seamon, K. B., Milton, K. & Myers, C. W. (1992) Proc. Natl. Acad. Sci. USA 89, 10960-10963. 15. Richter, K., Egger, R., Negri, L., Corsi, R., Severini, C. & Kreil, G. (1990) Proc. Natl. Acad. Sci. USA 87, 4836-4839. 16. Porto, A. M. & Gros, E. (1971) Experientia 27, 506. 17. Eisner, T., Wiemer, D. F., Haynes, L. W. & Meinwald, J. (1978) Proc. Natl. Acad. Sci. USA 75, 905-908. 18. Brower, L. P., van Zandt Brower, J. & Corvino, J. M. (1967) Proc. Natl. Acad. Sci. USA 57, 893-898. 19. Matsui, T., Hamada, S. & Konosu, S. (1981) Bull. Jpn. Soc. Sci. Fish. 47, 535-537. 20. Shimizu, Y. & Kobayashi, M. (1983) Chem. Pharm. Bull. 31, 3625-3631. 21. Yotsu, M., Yasumoto, T., Kim, Y. H., Naoki, H. & Kao, C. Y. (1990) Tetrahedron Lett. 31, 3187-3190. 22. Daly, J. W., Myers, C. W., Warnick, J. E. & Albuquerque, E. X. (1980) Science 208, 1383-1385. 23. Daly, J. W., Garraffo, H. M. & Spande, T. F. (1993) in The Alkaloids, ed. Cordell, G. A. (Academic, San Diego), Vol. 43, Chap. 3, pp. 185-288. 24. Myers, C. W., Daly, J. W. & Malkin, B. (1978) Bull. Am. Mus. Nat. Hist. 161, 307-365. 25. Daly, J. W., Secunda, S. I., Garraffo, H. M., Spande, T. F., Wisnieski, A. & Cover, J. F., Jr. (1994) Toxicon 32, 657-663.
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