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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine.

This study was supported by the Comparative Medicine Program, National Center for Research Resources the Interagency Research Animal Committee, and the Office for Protection from Research Risks, National Institutes of Health/Department of Health and Human Services; the U.S. Department of Agriculture; and the Department of Veterans Affairs. The grant was awarded by the Comparative Medicine Program, National Center for Research Resources, and all agency funding was provided under grant NIH RR08779-02.

Core support is provided to the Institute of Laboratory Animal Resources by the Comparative Medicine Program, National Center for Research Resources, National Institutes of Health, through grant number 5P40RR0137; the National Science Foundation through grant number BIR-9024967; the U.S. Army Medical Research and Development Command, which serves as the lead agency for combined U.S. Department of Defense funding also received from the Human Systems Division of the U.S. Air Force Systems Command, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, and U.S. Naval Medical Research and Development Command, through grant number DAMD17-93-J-3016; and by Research Project Grant #RC-1-34 from the American Cancer Society.

Any opinions, findings, and conclusions or recommendations expressed in this publication do not necessarily reflect the views of DHHS or other sponsors, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. government or other sponsors.

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Copyright 1996 by the National Academy of Sciences. All rights reserved.

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First Printing, July 1996

Second Printing, October 1996

Third Printing, November 1997



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