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Carcinogens and Anticarcinogens in the Human Diet: A Comparison of Naturally Occurring and Synthetic Substances (1996)
Commission on Life Sciences (CLS)

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407
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Appendix C
Chemical Compounds Occurring in Dietary Plants that Have Been Reported to Inhibit Carcinogenesis in Vivoa

Class

Compound Name

Inducer

Species (Routeb)

Amino acid

Cysteine

1,2-Dimethylhydrazine

Mouse (po)

 

(DL)-Tryptophan

Benzidine

Mouse (po)

Arylheptanoid

Curcumin

Methylazoxymethanol; N-Methyl-N'nitroso-urea; Benzo(a)pyrene; TPA; TPA; 20-Methylcholanthrene; DMBA + Croton oil

Mouse (po); Rat (po); Rat (po); Mouse (ext); Mouse (ip); Mouse (sc); Mouse (ext)
Page
407

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OCR for page 407
--> Appendix C Chemical Compounds Occurring in Dietary Plants that Have Been Reported to Inhibit Carcinogenesis in Vivoa Class Compound Name Inducer Species (Routeb) Amino acid Cysteine 1,2-Dimethylhydrazine Mouse (po)   (DL)-Tryptophan Benzidine Mouse (po) Arylheptanoid Curcumin Methylazoxymethanol; N-Methyl-N'nitroso-urea; Benzo(a)pyrene; TPA; TPA; 20-Methylcholanthrene; DMBA + Croton oil Mouse (po); Rat (po); Rat (po); Mouse (ext); Mouse (ip); Mouse (sc); Mouse (ext)

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--> Class Compound Name Inducer Species (Routeb) Benzenoid Gingerol Azoxymethane Rat (po) Carotenoid Canthaxanthin Benzo(a)pyrene; DMBA Mouse (po); rat (po) Carotenoid -Carotenal, 8-Apo Benzo(a)pyrene Mouse (po)   -Carotene Spontaneous liver CA Mouse (po)   -Carotene Benzo(a)pyrene; N-methyl-N'-nitroso-urea; DMN-OAC; DMBA Mouse (ext); Rat; Hamster (po); Mouse (ext)   Fucoxanthin N-Ethyl-N'-Nitro-N-nitroso-guanidine Mouse (po) Coumarin Aesculetin DMBA Rat (po)

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-->   Coumarin Benzo(a)pyrene Mouse (po)   Umbelliferone Benzo(a)pyrene Mouse (po) Cyclitol Myoinositol   Mouse (po)   Phytic acidc DMBA Rabbit (po) Diterpene Cafestol DMBA Hamster (po)   Cafestol Palmitate DMBA Rat (po)   Kahweol DMBA Hamster (po) Flavonoid Amorphinospirone TPA Mouse (ext)   Apigenin DMBA/TPA Mouse (ext)   Myricetin DMBA + Benzo(a)pyrene + TPA Mouse

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--> Class Compound Name Inducer Species (Routeb)   Quercetinc Azoxymethanol; DMBA; Teleocidin; Benzo(a)pyrene; Benzo(a)pyrene; Benzo(a)pyrene diol epoxide Mouse (po); Rat (po); Mouse (ext); Mouse (ext); Mouse (ip); Mouse (ip)   Robinetin Benzo(a)pyrene; Benzo(a)pyrene; Benzo(a)pyrene diol Mouse (ext); Mouse (ip); Mouse (ip)   Rutin Azoxymethanol Mouse (po) Indole Alkaloid Indole-3-carbinol 4-Nitroquinoline-1-oxide; Diethylnitrosamine +; N-methylnitrosourea +; N,N-dibutyl-nitrosamine; Spontaneous mammary tumors Rat (po); Rat (po); Mouse (po) Isoflavonoid Biochanin A Benzo(a)pyrone Mouse (ip)

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--> Lactone -Angelicalactone Benzo(a)pyrene Mouse (po) Lignan Sesamin DMBA Rat (po) Monoterpene Carveol DMBA Rat (po)   Limonenec DMBA; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; Same; N-Ethyl-N-Hydroxy-nitrosamine Rat (po); Rat (po); Rat (ip); Rat (po)   (-) Menthol DMBA Rat (po)   para-Mentha-2-8-dien-1-ol Benzo(a)pyrene Mouse (po)

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--> Class Compound Name Inducer Species (Routeb) Organic acid Fumaric acid N-Methyl-N'-nitroso-urea; N-Methyl-N-benzylnitrosoamine; N-Ethyl-N-nitrosurea; 3'-Methyl-4-(Dimethylamino)azobenzene Hamster (po); Rat (po); Rat (po); Rat (po) Phenolic acid Gallic acid   Mouse (po)   Protocatechuic acid Azoxymethane Rat (po) Phenylpropanoid Caffeic acid 4-Nitroquinoline-1-oxide Benzo(a)pyrene Rat (po); mouse (po)   Chlorogenic acid 4-Nitroquinoline-1-oxide Rat (po)   Cinnamic acid, ortho-hydroxy Benzo(a)pyrene Mouse (po)   Eugenolc DMBA Mouse (ext)

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-->   Ferulic acid 4-Nitroquinoline-1-oxide; Benzo(a)pyrene Rat (po); Mouse (po)   Myristicin Benzo(a)pyrene Mouse (po)   Myristicin, dihydro Benzo(a)pyrene Mouse (po) Sesquiterpene Nerolidol Azoxymethane Rat (po) Sterol Sitosterol MNU Rat (po) Sulfur compound Diallyldisulfide DMBA or TPA Mouse (ext)

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--> Class Compound Name Inducer Species (Routeb)   Diallysulfide Nitrosomethylbenzylamine; DMBA; DMBA; DMBA or TPA; MNNG; 1,2-Dimethylhydrazine; Diethylnitrosamine; + N-methylnitrosourea; + N,N-dibutylnitrosamine; N-Nitrosodiethylamine; 4-(Methylnitrosoamino)-1 butanone; N-Nitrosodimethylamine Rat (po); Hamster (po); Rat (po); Mouse (ext); Rat (po); Mouse (po); Pig (po); Rat (ip); Rat (ip); Rat (ip)   Benzyl isothiocyanate Diethylnitrosamine; Diethylnitrosamine; Benzo(a)pyrene; NNK; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Rat (po); Mouse (po); Mouse (po); Mouse (po); Mouse (po)

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-->   Isothiocyanate, Phenethyl 4-(Methylnitrosamino)-1-(3- pyridyl)-1- butanone; N-Nitrosomethylbenqyl-amine; Same; NNK Mouse (po); Rat (po); Mouse (po); Mouse (po)   Sinigrin 4-Nitroquinoline-1-oxide Rat (po) Tannin Ellagic acid 4-(methylnitrosamino-1-(3- Pyridyl)-1- butanone; 4-Nitroquinoline-1-oxide; N-Nitrosobenzmethylamine; Azoxymethane; DMBA; Benzo(a)pyrene; Benzo(a)pyrene; Benzo(a)pyrene diol epoxide; Benzo(a)pyrene diol epoxide; 3-Methylcholanthrene Mouse (po); Rat (po); Rat (po); Rat (po); Rat (po); Mouse (ext); Mouse (ip); Mouse (ext); Mouse (ip); Mouse (po)

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--> Class Compound Name Inducer Species (Routeb)   (-)-Epigallocatechin-3- gallate X-ray; Spontaneous liver tumors; N-Ethyl-N'Nitro-N- nitrosoguanidine; Nitrosamine-4-(methyl- nitrosamino)-1-(3- pyridyl)-1-butanone Rodents; Mouse (po); Mouse (po); Mouse (po); Mouse (po)   Tannic acid DMBA + benzo(a)pyrene +; TPA; Benzo(a)pyrene Mouse; Mouse (po) Triterpene Glycyrrhetinic acid Teleocidin; Azoxymethane; Methylazoxymethane; DMBA; DMBA or TPA Mouse (ext); Rat (po); Mouse (po); Mouse (po); Mouse (ext)   Limonin DMBA Hamster (ext)

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-->   Oleanolic acid Azoxymethane; DMBA; TPA Rat (po); Mouse (ext); Mouse (ext)   Ursolic acid DMBA; TPA Mouse (ext); Mouse (ext) Triterpene glycoside Glycyrrhizin DMBA Mouse (po) Xanthine Alkaloid Caffeinec Estradiol + progesterone; Diethylstilbestrol Mouse (po) rat (ip) a Data obtained from the NAPRALERT database of natural products. On-line access is available through the Scientific and Technical Network (STN) of Chemical Abstract Services. Data presented are intended to be illustrative but may not be complete. b The following abbreviations are used to indicate route: ext: external po: oral, in diet or drinking water, sometimes gastric administration ip: intraperitoneal sc: subcutaneous c Plant species containing this compound are listed in Appendix A.

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Representative terms from entire chapter:

spontaneous liver