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F Research and Related Activities on Health Problems of Persian Gulf War Veterans Investigator Affiliation Status (May Study or Study Center 1996) Mortality Studies Mortality follow-up study of PG VACO Completed veterans Comparative Mortality Among U.S. WRAIR Completed Military Personnel Worldwide (Writer et al., During ODS/S 1996) Hospitalization Studies Comparative study of hospitalizations NHRC, San Diego, Completed among active duty military Calif. personnel Comparison of federal and nonfederal NHRC, San Diego, In progress hospitalization rates among Calif. veterans who have separated from active service Studies of Self-Reported Symptoms: Outbreaks Investigation of a possible outbreak WRAIR Completed among ODS veterans at Fort (DeFraites et Benjamin Harrison, Ind. al., 1992) Post-PG illness reported in Naval NEPMU No. 2, Completed Reserve Mobile Construction Norfolk, Va. Battalion 24 Continued 175

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176 HEALTH CONSEQUENCES OF THE PERSIAN GULF WAR Investigator Affiliation Status (May Study or Study Center 1996) CDC investigation of veterans in Pennsylvania CDC Phase I completed (MMWR, 1995~; Phase II completed; Phase III In progress Studies of Self-Reported Symptoms: Surveys National Health Survey of PG VACO In progress Veterans and Their Family Members A study of symptoms among 1,500 NHRC, San Diego, Completed Seabees PG and era Calif. Seabee health study NHRC, San Diego Submitted to Calif. OMB Health Assessment of POW Veterans Cooperative agreement In progress from Iowa . between the CDC and University of Iowa, and the Iowa VAMC Reproductive Health Studies A Comparative Study of Pregnancy NHRC, San Diego, Completed Outcomes tBirth Defects] Among Calif. Gulf War Veterans and Other Active Duty Personnel Reproductive Outcomes in Gulf War NHRC, San Diego, In progress Veterans Calif. Prevalence of congenital anomalies NHRC, San Diego, In progress reported in state birth defects Calif. registries among children born to POW veterans

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APPENDIX F 177 Study Investigator Affiliation or Study Center Status (May 1996) Studies of Mental Health Stress-related surveys of active duty, guard, and reserve personnel The General Well-Being of Gulf War Era Service Personnel from the States of Pennsylvania and Hawaii: A Survey Desert Storm Reunion Survey Early intervention with Appalachian Marine reservists in ODS Investigation of relation between experience in ODS and postwar adjustment Psychological assessment of ODS returnees Evaluation of Cognitive Functioning in PG Veterans Reporting War- Related Health Problems Memory and Attention in PTSD Neuropsychological Functioning in Veterans Psychological adjustment in ODS/S veterans WRAIR, Dept. of Psychiatry WRAIR, USAMRMC Boston, Mass., VAMC Mt. Home, Tenn., VAMC Clarksburg, W.Va., VAMC and Dept. of Psychology, W.Va. University New Orleans, La., VAMC New Orleans, La., and Boston, Mass., VAMC New Orleans, La., VAMC New Orleans, La., VAMC Gainesville, Fla., VAMC Completed (Marlowe, 1995; Marlowe et al., 1990a,b; WRAIR, 1992; Wright et al., 1991) Completed (USAMRMC, 1994; Stretch etal., 1995, 1996) Expanded (Wolfe et al., 1992c, 1993) Completed (Sloan et al., 1992; 1995a,b; 1996a,b) Completed (Scott) et al., 1993) Expanded (Sutker et al., 1992, 1993, 1994a,b; l 995a,b) In progress In progress Completed Completed (Sohler et al., 1992) Continued

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178 HEALTH CONSEQUENCES OF THE PERSIAN GULF WAR Investigator Affiliation Status (May Study or Study Center 1996) ODS Outreach Program Cincinnati, Ohio, Completed VAMC (Baker et al., 1992) West Haven VAMC ODS Report West Haven, Conn., Completed VAMC (Southwick and Morgan, 1992; Southwick et al., 1993) The PG Outreach Program at the Little Rock, Ark., Completed Little Rock VAMC VAMC (Rodell et al., 1992) An Evaluation of Troops Returning Providence, R.I., Completed from the PG: A Preliminary VAMC (Unger et al., Report 1 992) Coming Home for Good: The ODS Portland, Greg., VAMC Completed Veterans and Family Psychosocial (Ford et al., Debriefing Project 1992) PG Veterans Seen Through VA's Washington, D.C., Completed Readjustment Counseling Service VAMC (Blank end and Impact of the POW on VA's Gelsomino, Provision of Readjustment 1992) Counseling The Need for Continuing Mental Highland Drive, Pa., Completed Health Intervention in Soldiers VAMC (Pontiusetal., Returning from the POW: 1992) Assessment of Deployed and Nondeployed Reserve Units from Western Pennsylvania, Eastern Ohio, and West Virginia Acute and long-term impact of deployment to SWA on the physical and mental health of soldiers and their families Combat Stress Diagnosis, PTSD prevention Women's Health Studies Health and Psychosocial Readjustment of Gulf War Women USUHS and WRAIR In progress USA~MC and New Ongoing Haven, Conn., VAMC U. Michigan School of Completed Nursing (Pierce, 1995, 1996)

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APPENDIX F 179 Study Investigator Affiliation or Study Center Status (May 1996) Completed (Nelson et al., 1996) Activation Experiences During the POW VA EHRC East Orange, N.J. Health and exposure survey of PG veterans Physiological and psychological assessments of PG veterans Effects of exertion and chemical stress on PG veterans Effects of genetics and stress on responses to environmental toxins Portland, Oreg. Core Epidemiology Study Psychosocial, neuropsychological, and neurobehavioral assessment Clinical and neuroendocrine aspects of fibromyalgia Neurotoxicity of environmental pollutants and warfare agents DNA damage from chemical agents and its repair Boston, Mass. Evaluation of cognitive functioning of PG veterans Evaluation of neurological functioning in PG veterans Gulf War and Vietnam veterans cancer incidence surveillance Evaluation of respiratory dysfunction among Gulf War veterans The aromatic hydrocarbon receptor as a biomarker of susceptibility Validity of computerized tests Beth El College of Nursing, Colorado Springs, Colo.; Air Wyoming Air National Guard, Cheyenne, Wyo. East Orange, NJ., In progress VAMC Portland, Greg., In progress VAMC Boston, Mass., VAMC In progress Continued

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180 HEALTH CONSEQUENCES OF THE PERSIAN GULF WAR Study Environmental Studies Air-quality studies Kuwait Oil Fires: Interagency Interim Report Investigator Affiliation or Study Center Status (May 1996) . Report to Congress: U.S. Gulf Environmental Technical Assistance (January 27-July 31, 1991) Human studies Report to Congress: Health Consequences of the exposure of PG Force members to the Fumes of Burning Oil Environmental toxicology studies Kuwait Oil Fire Health Risk Assessment Biologic Surveillance Initiative Animal studies Assessment of histopathological lesions and chemical analyses of feral cats to smoke from Kuwait oil fires Interagency Air Assessment Team (EPA, DHHS, NOAA) and representatives from Coast Guard, DoD, and DoE International cooperative effort coordinated by UN; U.S. activities coordinated by EPA (PL 102-27) DoD AFIP Completed (EPA, 1991) Completed (U.S. Gulf Environmental Technical Assistance, 1992) Completed (DoD, 1993) Completed (AFIP, 1994; Moeller et al., 1994; Peterson and Kal as in sky, 1996) USAEHA (currently Completed USACHPPM) (USAEHA, 1992, 1994) USAEHA (currently Completed USACHPPM); AFIP (USAEHA, 1994) AFIP Completed (Moeller et al., 1994)

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APPENDIXF 181 Study Investigator Affiliation Status (May or Study Center 1996) Physiological and neurobehavioral effects in rodents from exposure to PB, fuels, and DEET (toxicity of simulated POW exposure) PB synergistic toxicity study Chronic organophosphorus exposure and cognition USAMRMC In progress USAMRMC Medical College of Georgia Research Institute Evaluation of MWDs that participated DoD Working Dog in ODS/S Center, Lackland AFB, San Antonio, Tex. Completed (USACHPPM, 1995) In progress In progress DU Research Health risk assessment of embedded AFRRI In progress DU: behavior, physiology, histology, and biokinetic modeling Carcinogenicily of DU fragments ITRI In progress Prophylactic Treatment Research A Study to Evaluate the Safety USAMRMC Completed Tolerance, Pha~macokinetics, and (contracted to the South (Lasseter and PharmacodynamicsofPB Florida Research Garg, 1996) Corporation) Retrospective studies involving USAMRICD Completed military use of pyridostigmine as pretreatment for nerve agent poisoning Possible relationship between multiple chemical sensitivity- of DEET and carbamate (pyridostigmine) in POW veterans' illnesses WRAIR; WRAMC In progress Information Systems Activities GIS USACHPPM In progress VA PGHR VACO Ongoing VA PG Referral Centers Washington, D.C.; Ongoing Houston, Tex., West Los Angeles, Calif.; Birmingham, Ala. Continued

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182 HEALTH CONSEQUENCES OF THE PERSIAN GULF WAR Study Investigator Affiliation or Study Center Status (May 1996) Ongoing Ongoing DoD CCEP DoD SCC Pilot Studies Risk Factors Among U.S. Army Soldiers for Enrolling on the VA PGHR Extent of musculoskeletal problems associated with "GWS" Etiology of dyspnea occurring after POW service Antibody testing for mycoplasma Diarrhea in PG veterans: an irritable bowel-like disorder Clinical studies in PG veterans Post-Desert Storm miscarriage rates in six Army hospitals Birth defects and miscarriages in the families of PG veterans assigned to Robins AFB, Ga. Spontaneous abortion rate and the Gulf War mobilization Children of PG veterans (624th quartermaster, 786 transportation) Retrospective survey of PG troops who received Clostridium botulinum toxoid Chronic Gastrointestinal Illness in Desert Storm Veterans: A Survey and Questionnaire A Preliminary Neuropsychological Study of PG Veterans ODS: Activation, deployment and re- integration experiences of VAMC employees DoD MTFs WRAMC VACO; WRAIR Long Beach, Calif., VAMC Washington, D.C., VAMC WRAMC Gainesville, Fla., VAMC Allen Park, Mich., VAMC U.S. Army, Office of the Surgeon General Robins AFB, Ga. William Beaumont Army Medical Center, Tex. Jackson, Miss., VAMC; CDC; Miss. State Health Department USAMMDA Boston, Mass., VAMC Highland Drive, VAMC; Pittsburgh, Pa. Salt Lake City, Utah, VAMC In progress In progress In progress Completed In progress Ongoing Completed (Broadnax, 1992) Completed (Eggert, 1994) Completed (Rosa, 1993) Completed (Penman et al., 1996) Completed In progress Completed (Goldstein et al., 1996) Completed (Allen et al., 1991)

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APPENDIXF 183 Study Investigator Affiliation Status (May or Study Center 1996) Supporting Research Leishmaniasis and infectious disease research Development of a leishmania skin test USAMRMC antigen Identification of the genetic factors that control tropism in Leishmania Vaccine-Mediated Immunity Against Leishmania Serologic diagnosis of viscerotropic leishmaniasis Protective immunity in experimental visceral leishmaniasis Use of immunological techniques to study the interaction of carcinogens with DNA DoD/VA Cleveland, Ohio, VAMC USALfRMC San Antonio, Tex., VAMC NCI/NIH Forward deployable diagnostics for USAMRMC infectious diseases Ongoing Ongoing Ongoing Ongoing Ongoing Ongoing Ongoing NOTE: AFB = Air Force base; AFIP = Armed Forces Institute of Pathology; AFRRI = Armed Forces Radiation Research Institute; CCEP = Comprehensive Clinical Evaluation Program; CDC = Centers for Disease Control and Prevention; DEET = N,N,- diethyl-m-toluamide; DHHS = Department of Health and Human Services; DNA = deoxyribonucleic acid; DoD = Department of Defense; DoE = Department of Energy; DU = depleted uranium; EHRC = Environmental Health Research Center; EPA = Environmental Protection Agency; GIS = Geographical Information System; GWS = Gulf War Syndrome; ITRI = Inhalation Toxicology Research Institute; MTF = medical treatment facility; MWD = military working dog; NCI = National Cancer Institute; NEPMU = Navy Environmental and Preventive Medicine Unit; NHRC = Naval Health Research Center; NIH = National Institutes of Health; NOAA = National Oceanographic and Atmospheric Administration; 0DS = 0peration Desert Storm; 0DS/S = 0peration Desert Shield/Storm; PB = pyridostigmine bromide; PG = Persian Gulf; PGHR = Persian Gulf Health Registry; PGW = Persian Gulf War; PTSD = Posttraumatic stress disorder; SCC = Specialized Care Center; SWA = Southwest Asia; UN = United Nations; USACHPRM = U.S. Army Center for Health Promotion and Preventive Medicine; USAEHA = U.S. Army Environmental Hygiene Agency; USAMMDA = U.S. Army Medical Materiel Development Activity; USAMRICD = U.S. Army Research Institute of Chemical Defense; USAMRMC = U.S. Army Medical Research and Materiel Command; USUHS = Uniformed Services University of Health Sciences; VA = Veterans Administration; VACO = VA Central Office; VAMC = VA Medical Center; WMO = World Meteorological Organization; WRAIR = Walter Reed Army Institute of Research; and WRAMC = Walter Reed Army Medical Center.