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Pathways of Addiction: Opportunities in Drug Abuse Research
new drug development, 41
recommendations for research, 5 , 87
relapse behavior, 69
Antiaddiction medications, 27 , 29 .
See also Pharmacotherapy
Antisocial personality, 123 , 181
Anxiety disorders, 211
Arachidonic acid, 59
Assessment instruments, 201-202 , 239
B
Barbiturates, 66
Behavioral research
in abuse liability research, 38-39
on aggression and violence, 47-48
behavioral models, 36-37
contributions of, 3-4 , 35
craving response, 46-47
economic modeling, 49-50
future prospects, 50-51
learning and conditioning in treatment models, 41-42
on motivation for drug use, 43-45
neuroscience research and, 37-38
for pharmacotherapies, 39-41 , 203
recommendations for, 4 , 51
risk factors for drug use, 48-49
on withdrawal, 42
Benzodiazepines, 211
antagonists, 70
Biomarkers, 121 , 173-174
Bromocriptine, 71
Buprenorphine, 195-196
C
Ca2+ neurotransmitter pathway, 59 , 60
Cannabis. See Marijuana
Cerebral blood flow measurement, 73
Children/adolescents
antismoking campaigns, 145-146
community-based preventive interventions, 146
confidentiality issues in treatment, 270
consequences of prenatal drug exposure, 170-171 , 174-175
developmental risks in drug use, 8 , 166-167
epidemiological surveys, 99-101 , 106
parental drug abuse, 175
peer risk factors, 125-126
predictors of adult substance abuse, 122-123
preventive intervention design, 140
racial differences in drug use, 128
risk factors, 128-129
school-based prevention programs, 141-143 , 147-149 , 152
treatment considerations, 214-215
Clonidine, 68 , 70 , 71
Clorazepate, 211
Cocaine
aggressive behavior and, 47
antiaddiction medications, 203
brain glucose metabolism in use of, 73
craving response in users, 46-47
day hospital vs. inpatient treatment, 240-241
dopaminergic effects, 37 , 64 , 73 , 82
drug interactions, 173
effects on male reproduction, 174
extent of abuse, 2 , 21 , 193
extent of dependence, 102
immunization, 39-40 , 85
market characteristics, 260
maternal use during pregnancy, 166 , 167
neurochemical response, 61 , 64 , 68
pharmacological antagonists, 70
prenatal exposure, 171-172
treatment vs. drug control/interdiction, 199-200
violence linkage, 178-179
withdrawal, 67 , 68
See also Crack cocaine
Cognitive-behavioral psychology, 42 , 196
Community Epidemiology Work Group, 105