Vaccines for the 21st Century: A Tool for Decisionmaking

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Table of Contents
Front Matter R1-R12
Executive Summary 1-10
Introduction 11-16
Progress in Vaccine Development 17-38
Considerations of Candidate Vaccines 39-52
Overview of Analytic Approach and Results 53-92
Review of the Analytical Model 93-108
Ethical Considerations and Caveats 109-122
Observations 123-132
References 133-142
Appendix 1: Borrelia burgdorferi 143-148
Appendix 2: Chlamydia 149-158
Appendix 3: Coccidioides Immitis 159-164
Appendix 4: Cytomegalovirus 165-172
Appendix 5: Enterotoxigenic E. coli 173-176
Appendix 6: Epstein-Barr Virus 177-180
Appendix 7: Helicobacter pylori 181-188
Appendix 8: Hepatitis C 189-194
Appendix 9: Herpes Simplex Virus 195-206
Appendix 10: Histoplasma capsulatum 207-212
Appendix 11: Human Paillomavirus 213-222
Appendix 12: Influenza A and B 223-232
Appendix 13: Insulin-Dependent Diabetes Mellitus 233-238
Appendix 14: Melanoma 239-244
Appendix 15: Multiple Sclerosis 245-250
Appendix 16: Mycobacterium tuberculosis 251-256
Appendix 17: Neisseria gonnorrhea 257-266
Appendix 18: Neisseria meningitidis 267-272
Appendix 19: Parainfluenza Virus 273-278
Appendix 20: Respiratory Syncytial Virus 279-284
Appendix 21: Rheumatoid Arthritis 285-290
Appendix 22: Rotavirus 291-294
Appendix 23: Shigella 295-298
Appendix 24: Streptococcus, Group A 299-304
Appendix 25: Streptococcus, Group B 305-312
Appendix 26: Streptococcus pneumoniae 313-322
Appendix 27: Information on accessing Electronic Spreadsheets 323-324
Appendix 28: Summary of Workshops 325-434
Appendix 29: Questions Posed to Outside Experts and List of Responders 435-442
Index 443-460

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Table A12–1 Incidence and Mortality of Influenza A and B Disease

INCIDENCE RATES
5-Year Age Groups	Total Population	Incidence Rates (per 100,000) (5-yr age groups)	Cases	Age Groups	Population	Incidence Rates (per 100,000)	% Distribution of Cases
0–4	20,182,000	33,700	6,801,334	<1	3,963,000	33,700	0.0246
5–9	19,117,000	39,300	7,512,981	1–4	16,219,000	33,700	0.1006
10–14	18,939,000	30,200	5,719,578	5–14	38,056,000	34,771	0.2435
15–19	17,790,000	30,200	5,372,580	15–24	36,263,000	24,851	0.1658
20–24	18,473,000	19,700	3,639,181	25–34	41,670,000	15,500	0.1189
25–29	19,294,000	15,500	2,990,570	35–44	42,149,000	14,800	0.1148
30–34	22,376,000	15,500	3,468,280	45–54	30,224,000	14,800	0.0823
35–39	22,215,000	14,800	3,287,820	55–64	21,241,000	14,800	0.0579
40–44	19,934,000	14,800	2,950,232	65–74	18,964,000	14,800	0.0517
45–49	16,873,000	14,800	2,497,204	75–84	11,088,000	14,800	0.0302
50–54	13,351,000	14,800	1,975,948	• 85	3,598,000	14,800	0.0098
55–59	11,050,000	14,800	1,635,400	Total	263,435,000	20,627	1.0000
60–64	10,191,000	14,800	1,508,268
65–69	10,099,000	14,800	1,494,652
70–74	8,865,000	14,800	1,312,020
75–79	6,669,000	14,800	987,012
80–84	4,419,000	14,800	654,012
• 85	3,598,000	14,800	532,504
Total	263,435,000		54,339,576

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