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summarizes vaccine development assumptions for all vaccines considered in this report.

For the purposes of the calculations in this report, it is assumed that the costs associated with diagnostic phase would be incurred even with a treatment vaccine strategy. Therefore, only the costs of the treatment phase will be assumed to be averted with a vaccine strategy.

VACCINE DEVELOPMENT

The committee assumed that it will take 15 years until licensure of a therapeutic IDDM vaccine and that $360 million needs to be invested. Table 4–1 summarizes vaccine development assumptions for all vaccines considered in this report.

VACCINE PROGRAM CONSIDERATIONS

Target Population

For the purposes of the calculations in this report, it is assumed that the target population for this vaccine is all newly diagnosed cases of IDDM. It was assumed that 90% of the target population would utilize the vaccine.

Vaccine Schedule, Efficacy, and Costs

For the purposes of the calculations in this report, it was estimated that this vaccine would cost $500 per dose and that administration costs would be $10 per dose. Default assumptions for therapeutic vaccines of a 3-dose series and 40% effectiveness were accepted. Table 4–1 summarizes vaccine program assumptions for all vaccines considered in this report.

RESULTS

If a vaccine program for IDDM were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the QALYs gained would be 170,000. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the QALYs gained would be 38,000.



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