Cover Image


View/Hide Left Panel

TABLE 3–1 Candidate Vaccines Included for Full Analysis*

Borrelia burgdorferi


Coccidioides immites


Enterotoxigenic E. coli

Epstein-Barr virus

Helicobacter pylori

Hepatitis C virus

Herpes simplex virus

Histoplasma capsulatum

Human papillomavirus


Insulin-dependent diabetes mellitus (therapeutic)

Melanoma (therapeutic)

Multiple sclerosis (therapeutic)

Mycobacterium tuberculosis

Neisseria gonorrhea

Neisseria meningitidis B


Respiratory syncytial virus

Rheumatoid arthritis (therapeutic)



Streptococcus, group A

Streptococcus, group B

Streptococcus pneumoniae

*Candidate vaccines are preventive unless indicated as (therapeutic).

Insufficient Basic Science Information

The Committee judged that a vaccine approach to control a number of diseases caused by microorganisms was not attainable within the next 20 years. In some instances not enough information was available concerning the antigens that stimulate protective immune response or the host responses necessary to provide protection. In other cases, a class of infectious agents are known to cause disease (e.g., periodontal disease), but the major contributors to disease within that class are not yet identified. In other cases, knowledge of the natural history of the infection was inadequate. Some of these infectious diseases against which vaccines were not yet considered feasible occur in healthy hosts who experience the loss of integrity of the skin or the disruption of normal intestinal barriers to microorganisms, which permits the development of secondary infections (e.g., infections caused by Clostridium perfringens or Bacteroides fragilis). Other diseases are the result of intimate exposure of healthy hosts to others who harbor certain pathogens (e.g., Treponema pallidum and Mycobacte

The National Academies of Sciences, Engineering, and Medicine
500 Fifth St. N.W. | Washington, D.C. 20001

Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement