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CARL RICHARD MOORE December 5, ]892-October 16, 7955 BY DOROTHY PRICE WHEN THE DISTINGUISHED endocrinologist Carl R. Moore died, a document of great importance to a biographer lay in his desk. It was headed "Biographical data prepared for files of National Academy of Sciences," and it was dated August 28, 1948, seven years before his death. Oddly enough, I remember that day and that occasion. I had gone to his office at the end of a particularly hot, muggy, Chicago day and had found him pecking away at an old typewriter in his inimitable fashion with one finger of each hand. When he said that he was writing biographical data for the National Academy of Sciences, I may have been somewhat surprised because he had been a mem- ber of the Academy since 1944. In any case, my memory caught and recorded the incident. I was to see the contents of those pages after his death and to recall him vividly as I knew him, the professor under whom I wrote my doctoral thesis in the Department of Zoology of the University of Chicago, the scientist with whom I served as a close collaborator for many years in studies on the physiology of reproduction, the chair- man of a department in which I later became his colleague. What he wrote in 1948 is remarkable in that he painted, quite unknowingly, an extraordinarily revealing picture of his life and scientific career as he saw them. Viewed through his eyes, his career was the proverbial one of the farm boy of limited 385
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386 circumstances who makes good mainly by dint of his own hard work and ambition. It is a typically American story, and in an ingenuous and engaging way he showed his satisfaction and pride that this was his story. He had indeed "made good" and could look with understandable pride at his position and ac- complishments, his honors and awards. A biographer who had never known Carl Moore might have been puzzled to find that more than one third of the six pages in his biographical notes of 1948 were devoted to a nostalgic recounting of his experiences on the farm in the Ozark region of Missouri where he was born and to details of his life and early schooling in Springfield. To me, this came as no great surprise. He had often talked at length about his beloved Ozark country background, and the subject was always close to the surface of his mind. But when he wrote these biographical data his thoughts were certainly resting on a past that was illuminated for him by a rosy light. He had recently been granted an honorary degree from Drury College in Springfield, where he had received his B.S. and M.S. degrees. A visit to the scenes of his early years and a reunion with his family had undoubtedly revived old memories. But an additional reason for his preoccupation with his early vears seems Probable. He BIOGRAPHICAL MEMOIRS , , 1 had sometimes spoken to me about returning to his Ozark O country when he retired, perhaps to a farm near Springfield. In August of 1948, at the age of fifty-five years, he mentioned in his biographical notes that he had nine years before official retirement. He was apparently looking forward as well as backward, and a plan to retire to an ideal country spot near Springfield and its Drury College may well have crystallized in his mind. His life might then have ended where it began, but death anticipated him, and he did not live to retirement. Carl Moore was born on December 5, 1892, on a farm in Green County, Missouri, twelve miles from the city of Spring- field. His father, whose family was originally of Scottish an-
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C A R L R I C H A R D M O O R E 387 cestry, had been taken from Tennessee to southwest Missouri at the age of ten in a covered wagon drawn by oxen; Moore's mother, whose distant ancestors were English, was born in Missouri just before the Civil War. The farm on which Carl was born was cleared land cut from surrounding forest. Here life was simple, frugal, religious, and relatively primitive, and the boy learned to work hard and to do all the usual farm chores. He also learned to hunt and fish, and fishing remained a favorite outdoor sport and means of relaxation all his life. When he began school, he went to a one-room country school in which the teacher was one of his older sisters. A new period began for him when he reached the age of nine years and his family removed to Springfield, a town of 20,000 people at that time. In this much less restricted environ- ment, he went through elementary school and high school and entered Drury College. His family had discussed whether he should be "a preacher or a doctor," but the matter must have been settled by the time he registered in college as a premedical student. His tuition was paid largely from money he earned by doing all sorts of odd jobs, such as janitor service, window- washing, and delivering papers. But it was not all work. He still had time and abundant energy for tennis, horseback riding, hunting, and fishing. At Drury College, Carl Moore found the teacher who un- questionably shaped the pattern of his future life in scientific research and teaching. Moore should speak for himself on this point just as he did in his biographical data: "In college, biology in addition to being a rather natural interest from earlier farm experiences, became a favorite sub- ject largely because of the commanding personality of the teacher, Charles Haddon Spurgeon; he was a self-made, jolly, fat man, of large physical stature who inspired youngsters by providing opportunity for work outside the regular curriculum. Being considerable of a critic, his encouragement and com-
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388 BIOGRAPHICAL MEMOIRS mendations were vitalizing. Preparation of slides for histology, serial sectioning of embryos, and many additional activities in the laboratory occupied many all night sessions as well as those on Saturdays and Sundays." When Moore spoke of Spurgeon's "power over youngsters" he knew whereof he spoke. Spurgeon's example was firmly im- printed on him as a young, eager student. He, too, became just such an inspiring and enthusiastic teacher, and he, too, gave undergraduate students an opportunity to work on projects outside the regular curriculum (often in his own research, with joint publication as an additional bonus). As for dedica- tion to night and weekend work in the laboratory, Moore was a convert, and so were those of us who worked with him. In- deed, it was often necessary for our experiments, but it became a habit and, ultimately, almost a compulsion. It stayed with him in the last years of his life during his failing health, and I would find him in his office on Sunday mornings when he had hardly strength enough to lift his packed briefcase. At Drury College, extracurricular laboratory work was a joy to the young Carl Moore. It held opportunities for ad- venture and exploration and a chance to solve the problems he met by some method of his own devising, be it orthodox or un- orthodox. I can supplement his own biographical notes with a significant anecdote. When he had difficulty in obtaining good serial sections of embryos because the paraffin blocks crushed, he met his problem in a direct fashion by opening all the windows to let in cold air, putting on overcoat and muffler, and cranking the microtome around to cut again (with better suc- cess). There were much simpler and less heroic ways to obtain perfect serial sections, but he did not know them. It is doubt- ful that Spurgeon knew much about the matter either, but he seems to have given his students free rein to use their own initiative with whatever simple equipment was available and come up with the best results they could.
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CARL RICHARD MOORE 389 Moore learned these lessons well. In his own direction of the research of his graduate students, he allowed them free rein for months at a time to let them "find their own feet" (unless they came to him for help and advice). Some floundered hope- lessly and dropped out: some completed their research project . . . In a pecrestr~an way on well-worn paths; but some learned the priceless benefit of being free to develop independence, initia- tive, and imagination as Moore had learned earlier. They learned, too, to use relatively simple equipment with only the minimum of refined instruments. Money was not wasted on new and showy gadgets—good research did not depend upon such things. Moore was wont to conduct our distinguished guests through our research laboratories, operating rooms, and animal quarters and report to me afterward that he liked to show them what research could come out of a "setup" like ours. And he was right in large measure. An ever-increasing volume of good research was done under relatively primitive conditions; he did not ask for more. In later years, of course, he recognized the obvious advantages of modernization and . . . . air cone .ltlonlng. We may be sure that there were no special refinements in the Biology Department of Drury College when Moore was studying biology under Spurgeon, learning embryology from Lillie's Development of the Chick, and enthusiastically carry- ing on extracurricular projects. He obtained his B.S. degree in the spring of 1913. His family had no money to send him to medical school, but another opportunity opened. He was of- fered a position at Drury as an assistant in biology. The posi- tion carried a munificent salary of $100 for the year, and he could work under Spurgeon for an M.S. degree (incidentally, one of the very few ever granted by that institution, as Moore states in 1948~. Moore snapped at the chance. But before he began his fifth and final year at Drury, he came to the University of Chicago and registered for summer quarter courses in the
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390 Department of Zoology. Lillie's textbook had caught his inter- est and piqued his curiosity about the department where the famous embryologist was chairman. Of course, Lillie was not there—he spent every summer at the Marine Biological Labora- tory at Woods Hole—but there was much to see and much to learn at the University of Chicago, and it was Moore's first trip away from home. To obtain his M.S. degree at Drury, which he did in June of 1914, Moore assisted in courses and made what he later termed "an attempt at research" on the origin of the vena cave in bat embryos. He prepared slides of serial sections of embryos, projected the sections on melted beeswax, and by cutting out the projected sections and stacking them he produced models. He had never seen a wax model, but he made some in his own way (undoubtedly with the window open). This research problem might not seem the most interesting one for a young student. For him, it was an exciting foretaste of biological re- search, and he was thenceforth lost to medicine. He had applied to some universities for support for graduate study and received offers of fellowships from three. The one he accepted was from the University of Chicago, and in choosing this fellowship he made one of the most important decisions of his life. He would have made a name for himself wherever he had gone, but it is open to doubt whether he would have advanced as rapidly and his name have loomed so large if he had gone elsewhere. Moore came to work with the right man- Frank R. Lillie—at just the right time in the development of Lillie's research program. The Department of Zoology was an ideal environment in which Carl Moore could mature; when he received his Ph.D. degree he was to step into that department as a member just before the beginning of the 1920's, a decade of great and brilliant advances in endocrinology. And Moore was to be in the middle of it all. However, Moore could not gaze into the crystal ball. When BIOGRAPHICAL MEMOIRS
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CARL RICHARD MOORE 391 he went to Woods Hole for the summer session in 1914 and met Frank R. Lillie for the first time, the young man fresh from the Ozark hills was in a state of "uncertainty and trepidation" as he described it. Others, too, had found the dignified, reticent, soft-spoken embryologist overawing. But this first meeting for Carl Moore was a successful one, and he was assigned a doctoral problem in Lillie's large program of studies on the fertilization of the eggs of marine invertebrates. Lillie became his mentor, and Moore began to learn eagerly the elements of sophisticated scientific research and criticism from one of the best possible teachers. Moore always remained, in a sense, Lillie's protege, and Moore repaid him with profound admiration, respect, and affection. Fortunately, the young stu- dent did not try to emulate too closely the middle-aged man of great distinction who patiently directed him. That would have been disastrous; their backgrounds and personalities were very different. But when Moore later gave the seminars for which Lillie had been famous, "Biology of Sex" and "Physiology of Reproduction," he followed almost exactly not only the lucid organization but much of the subject matter of Lillie's brilliant introductions. Moore completed his doctoral thesis on fertilization and parthenogenesis in the eggs of a sea urchin in record time and received his Ph.D. degree from the University of Chicago in 1916. He was immediately appointed an associate in the De- partment of Zoology for the period from 1916 to 1918. He spent half the time in teaching an embryology course designed primarily for premedical students and the remainder in re- search. In 1918 he became instructor, and in the ensuing years he advanced rapidly, reaching a full professorship in 1928 and the chairmanship of the department in 1934. In the period from 1919 to 1920 an event of great importance in Carl Moore's life and in his scientific career occurred. A student named Edith Naomi Abernethy caught his attention in
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392 BIOGRAPHICAL MEMOIRS a laboratory section he was teaching. Soon his interest was more than academic, and they were married in July of 1920. He acquired not only an attractive and charming wife, but a hostess who presided with grace and competence on the many occasions when they entertained students and scientific visitors from many places in America (in the broad sense) and abroad. She under- stood his need to consider his laboratory also a "home," and she shared his love of nature and the outdoors. Their summer home in Michigan was a haven for him and a beloved spot for her. Their honeymoon was spent on a float trip on a river in the Ozarks (where else could it have being. Two of their three children survived—Harris Mason and Ellen Abernethy. After publishing his thesis, Moore completed a second paper on the sea urchin, Arbacia, and then turned abruptly to an entirely different line of research in which he was occupied for the rest of his scientific career. The reason was clear, but it requires explanation. Lillie published in 1916 the first of his classic papers on the freemartin, a bovine intersex that resulted from cases of heterosexual twinning when there were anasto- moses of blood vessels in the fused fetal membranes. The type of intersexuality and the sterility usually found in freemartins posed intriguing problems. Lillie's observations and his master- ful analysis resulted in a theory to explain freemartinism on the basis of masculinization of the female by male hormone pro- duced in the testes of the male co-twin and crossed to the female through the vascular anastomoses. The ovaries were inhibited (antagonized), and the duct systems and glands were masculin- ized (stimulated). He then proposed that normal sex differentia- tion in the mammalian fetus might be controlled by bloodborne substances, hormones, secreted by fetal testes and ovaries. How- ever, he cautioned that the theory was only tentative. Nothing was known about the possible effects of female hormone on the male fetus. Fetal gonadectomy—all-important for an under-
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CARL RICHARD MOORE 393 standing of normal sex differentiation—had never been accom- plished and should be done as a critical test of the theory. Lillie made "a mild suggestion" (in Moore's words) that Moore try to produce freemartins by experimental means. A mild suggestion was all that was required, and Moore plunged into the problem, or rather into the problems, for his research did not follow any straight path. Thirty-eight years and some one hundred publications later, he still had not produced free- martinism experimentally (nor, indeed, had anyone else). But by then he had developed a theory of his own to explain normal sex differentiation. This proposed that sex hormones from fetal gonads were not controlling normal sex differentiation. The evidence that he presented negated, in his opinion, Lillie's hormonal theory for freemartinism and its extension to normal sex differentiation. However, before Moore was led to this conclusion he made many outstanding contributions in the physiology of reproduction even as he digressed from his original purpose. Moore began his attempts to subject fetuses to male hormone and produce experimental freemartinism by transplanting testicular tissue onto the membranes of rat and guinea pig fetuses. This failed dismally. Then he transplanted testes into young females in the hope of obtaining freemartins in the litters when these females were ultimately bred. This, too, failed, but he was far from discouraged. He had succeeded in obtaining well-developed testicular grafts in young females. The field of gonad transplantation with its postulates of sex gland an- tagonism lay open before him. The Viennese scientist E. Steinach had first reported in 1910 that young spayed female rats and guinea pigs were masculinized when given grafts of testes, and young castrated males were feminized by grafts of ovaries but the hosts must be gonadectomized prior to receiving grafts. He therefore pro-
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394 BIOGRAPHICAL MEMOIRS posed and strongly defended, then and later, a concept of sex gland antagonism involving a direct antagonism between testis and ovary. The question of whether sex gland antagonism really existed was an important one. The validity of such a concept might have a direct bearing on Lillie's theory of freemartinism. Moore promptly sought confirmation or refutation of the concept and soon completely disproved it. He was successful In maintaining testis grafts in young females possessing ovaries and ovarian grafts in young males with testes. In these early experiments of Moore's there was a fortuitous circumstance that undoubtedly favored unusually successful "takes" of the grafts. He routinely exchanged one gonad each between young males and females at the time of grafting, apparently for efficient utilization of animals. Thus the grafts were placed in hosts that had just been hemispayed or hemicastrated. About ten years later, he and I were to propose a theory of balanced control between gonadal hormones and nituitarv ~onadotronins. , c7 rid --, =_ The experi- mental design that he used in 1919 had a sound rationale of which he never dreamed at the time. The grafts that he ob- tained differed so materially from those described by Steinach that he was led into his next research problems. Moore's grafts of testes had far better-developed tubules and fewer interstitial cells between them than those of Steinach. The two investigators agreed that spermatozoa were not present in the grafts. Contrary to Steinach, Moore found no evidence for increased hormone secretion and no basis for a contention that testis grafts might effect rejuvenation in senile animals and men. This fata morgana of warding off all changes of aging in man, or rejuvenating the senile, had appeared again. Testis- secreted hormone was the miraculous cure-all. In France, the Russian-French surgeon S. Voronoff was rejuvenating senes-
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CARL RICHARD MOORE BIBLIOGRAPHY 403 Am.1 AnaL ._ American journal of Anatomy Am. ] Obstet. Cynecol. American journal of Obstetrics and Gynecology Am. J. PhysioL - American Journal of Physlology Am. Naturalist. American Naturalist Anat. Record- Anatomica1 Record B101. BuU._ Biol~ica1 Bulletin J. Am. Wed. Assoc. - Journal of the American Medico Assoclation J. Can. Endocrinol. Journal of Clinical Endocrinology J. Exp. ZooL _ Journal of Experimenta1 Zoology J. Urol. = Journal of Orology Physiol . Zoo l. - Physiological Zoology Proc. Sac. Exp. BioL Wed. - Proceedings of the Society of Experimental Biology and Medians 1916 On the 6uperposidon of fertilization on parthenogenesis. Biot By, 31: 13~0. 1917 On the capacity for fertilization after the initiation of development. Biol. Bull., 33: 258-95. 1919 On the physiologica1 properties of the gonads as controllers of somatic and psychical characteristics. I. The rat. J. Exp. Zoom 28: 137-60. On the physiological properties of the gonads as controllers of somatic and psychical characteristics. II. Growth of gonadec- tomized male and female rate J. Exp. Zoot, 28:439-67. ^ th F k. Lime. ~ Bong O~e ~~d Af~/f~r'6e 37~> o~ ~ A. Chicago, Univershy of Chicago Press ix + 66 PP 1920 On the production of artificial hermaphrodites in mam male ScL ence, 52:179-82.
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404 BIOGRAPHICAL MEMOIRS 1921 Sex gland transplantation and the modifying effect in rats and guinea pigs. Anat. Record, 20:194. (A) On the physiological properties of the gonads as controllers of somatic and physical characteristics. III. Artificial hermaph- roditism in rats. i. Exp. Zool., 33:129-71. On the physiological properties of the gonads as controllers of somatic and psychical characteristics. IV. Gonad transplanta- tion in the guinea pig. J. Exp. Zool., 33:365-89. 1922 On the properties of the gonads as controllers of somatic and psy- chical characteristics. V. The effects of gonadectomy in the guinea pig on growth, bone lengths, and weight of organs of internal secretion. Biol. Bull., 43:285-312. 1923 Cryptorchidism experimentally produced. (A) On the relationship of the germinal epithelium to the position of the testis. Anat. Record, 25:142. (A) With F. R. Lillie. A Laboratory Outline of Embryology with Special Reference to the Chick and Pig. Chicago, University of Chicago Press. ix + 67 pp. With R. Oslund. Experimental studies on sheep testes. Anat. Record, 26: 343~4. (A) With W. l. Quick. A comparison of scrotal and peritoneal tempera- ture. Anat. Record, 26:344. (A) With H. D. Chase. Heat application and testicular degeneration. Anat. Record, 26:344. (A) Anat. Record, 24:383. 1924 The behavior of the germinal epithelium in testis grafts and in experimental cryptorchid testes (rat and guinea pig). Science, 59:41-44. With R. Oslund. Experiments on the sheep testis cryptorchidism, vasectomy and scrotal insulation. Am. I. Physiol., 67:595-607.
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CARL RICHARD MOORE 405 With W. I. Quick. The scrotum as a temperature regulator for the testis. Am. i. Physiol., 68: 70-79. The behavior of the testis in transplantation, experimental cryptor- chidism, vasectomy, scrotal insulation and heat application. Endocrinology, 8:493-508. The behavior of the testis under varying conditions and the function of the scrotum: transplantation, cryptorchidism, vasectomy. Minnesota Medicine, 7: 753-61. On the properties of else gonads as controllers of somatic and psychi- cal characteristics. VI. Testicular reactions in experimental cryptorchidism. Am. I. Anat., 34: 269-316. With W. T. Ouick. On the Properties of the Gonads as controllers of a _ 1 ~ ~ somatic and psychical characteristics. VII. Vasectomy in the rabbit. Am. i. Anat., 34:317-36. On the properties of the gonads as controllers of somatic and psychi- cal characteristics. VIII. Heat application and testicular degenera- tion; the function of the scrotum. Am. l. Anat., 34:337-58. 1925 Sex determination and sex differentiation in birds and mammals. Am. Naturalist, 59:177-89. Testicular displacement and temperature regulation (rat, guinea- pig). Anat. Record, 31:303. (A) 1926 The biology of the mammalian testis and scrotum. view of Biology, 1 :4-50. On the properties of the gonads as controllers of somatic and psychical characteristics. IX. Testis graft reactions in different environments (rat). Am. l. Anat., 37:351~16. The activity of displaced testes and its bearing on the problem of the function of the scrotum. Am. I. Physiol., 77: 59-68. The relation of the scrotum to germ cell differentiation in gonad grafts in the guinea pig. Am. Naturalist, 60:324-33. Scrotal replacement of experimental cryptorchid testes and the recovery of spermatogenetic function (guinea pig) . Biol. Bull., 51:112-28. On the effects of sex hormones in determining the sex ratio: a criticism of Kovac's paper. Am. i. Obstet. Gynecol., 11:703-05. Quarterly Re-
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406 BIOGRAPHICAL MEMOIRS 1927 A qualitative indicator for the testis hormone. Proc. Soc. Exp. Biol. Med., 24:847-48. The motility of spermatozoa as an indicator for the internal secre- tion of the testis. Anat. Record, 37: 119-20. (A) The effect of abdominal temperature on spermatozoa of the guinea pig. Anat. Record, 37:120. (A) The application of the spermatozoon motility reaction as an indi- cator for the testis hormone. Anat. Record, 37:120-21. (A) 1928 On the properties of the gonads as controllers of somatic and psychical characteristics. X. Spermatozoon activity and the testis hormone. J. Exp. Zool., 50:455-94. On the properties of the gonads as controllers of somatic and psychical characteristics. XI. Hormone production in the normal testes, cryptorchid testes and non-living testis grafts as indicated by the spermatozoon motility test. Biol. Bull., 55:339- 57. With L. C. McGee. On the effects of injecting lipoid extracts of bull testes into castrated guinea pigs. Am. J. Physiol., 87:436- 46. 1929 Studies on the testicle with especial reference to transplantation. Nebraska State Medical Journal, 14:184-87. With T. F. Gallagher. On the prevention of castration effects in mammals by testis extract injection. Am. J. Physiol., 89:388-94. With T. F. Gallagher and F. C. Koch. The effects of extracts of testis in correcting the castrated condition in the fowl and in the mammal. Endocrinology, 13:367-74. 1930 With T. F. Gallagher. Seminal vesicle and prostate function as a testis hormone indicator; the electric ejaculation test. Am. I. Anat., 45:39-69; also in Anat. Record, 44:202 (1929~. (A) With D. Price and T. F. Gallagher. Rat prostate cytology as a
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CARL RICHARD MOORE 407 testis-hormone indicator and the prevention of castration changes by testis-extract injections. Am. I. Anat., 45:71-107; also in Anat. Record, 44:203 (1929~. (A) With W. Hughes and T. F. Gallagher. Rat seminal vesicle cytology as a testis hormone indicator and the prevention of castration changes by testis extract injection. Am. l. Anat., 45: 109-35; also in Anat. Record, 44:203 (1929~. (A) With S. Vatna and T. F. Gallagher. The reaction of the rat vas deferens to castration and to testis-hormone injection. Anat. Record, 45:233. (A) The physiologic effects of non-living testis grafts. J. Am. Med. Assoc., 94:1912-15. A study of the testicle: effects of increased temperature, transplanta- tion and hormone production. Transactions of the American Association of Genito-Urinary Surgeons, 23: 287-96. With D. Price. The question of sex hormone antagonism. Proc. Soc. Exp. Biol. Med., 28: 38~0. With T. F. Gallagher. Threshold relationships of testis hormone indicators in mammals: the rat unit. Journal of Pharmacology and Experimental Therapeutics, 40: 341-50. 1931 A critique of sex hormone antagonism. Proceedings of the 2d In- ternational Congress for Sex Research, ed. by A. W. Greenwood, pp. 293-303. London, 1930. London, Oliver & Boyd, Ltd. Supplementary observations on mammalian testis activity. I. Vasa- efferentia ligation. II. Atypical scrota. Anat. Record, 48:105- 19. With L. T. Samuels. The action of testis hormone in correcting changes induced in the rat prostate and seminal vesicles by vitamine B deficiency or partial inanition. Am. I. Physiol., 96:278-88. The regulation of production and the function of the male sex hormone. I. Am. Med. Assoc., 97:518-22. With D. Price. Some effects of fresh pituitary homo-implants and of the gonad stimulating substance from human pregnancy urine on the reproductive tract of the male rat. Am. I. Physiol., 99: 197-208.
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408 BIOGRAPHICAL MEMOIRS 1932 With I). Price. Gonad hormone functions, and the reciprocal in- fluence between gonads and hypophysis with its bearing on the problem of sex hormone antagonism. Am. J. Anat., 50:13-67. The biology of the testis. In: Sex and Internal Secretions, ed. by E. Allen, pp. 281-371. Baltimore, The Williams & Wilkins Company. 1934 With G. F. Simmons, L. I. Wells, M. Zalesky and W. O. Nelson. On the control of reproductive activity in an annual-breeding mammal (Citellus tridecemlineatus). Anat. Record, 60:279-89. 1935 Hormones in relation to reproduction. 29: 1-18. Am. J. Obstet. Gynecol.' Testicular biology, scrotal function and the male hormone. New England Journal of Medicine, 212 :422-27. The testis hormone. In: Glandular Physiology and Therapy, pp. 257-78. Chicago, Am. Medical Assn.; also in l. Am. Med. Assoc., 104: 1405-11. Hormonal mechanisms in the control of reproductive phenomena. Transactions on the Dynamics of Development, 10:189-203. 1936 Responses of immature rat testes to gonadotropic agents. Am. J. Anat., 59:63-~. With L. l. Wells. Hormonal stimulation of spermatogenesis in the testis of the ground squirrel. Anat. Record, 66:181-200. 1937 With D. Price. Some effects of synthetically prepared male hor- mone (androsterone) in the rat. Endocrinology, 21:313-29. Testis hormone secretion and some effects of the hormone in the organism. Cold Spring Harbor Symposia on Quantitative Biology, 5: 115-22.
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CARL RICHARD MOORE 1938 409 With l. K. Lamar and N. Beck. Effectiveness of sex hormones ad- ministered as skin ointments. Anat. Record, 70:57-58. (A) Endocrines and male reproductive behavior. Proceedings of the American Society of Animal Production, 1938: 26-33. Science at the University of Chicago. Science, 87:278-79. With D. Price. Some effects of testosterone and testosterone propionate in the rat. Anat. Record, 71: 59-78. With J. K. Lamar and N. Beck. hormones. l. Am. Med. Assoc., 111:11-14. 1939 Cutaneous absorption of sex Biology of the testes. In: Sex and Internal Secretions, 2d ea., ed. by E. Allen, T. H. Danforth and E. A. Doisy, pp. 353-451. Balti- more, Williams & Wilkins Company. Modification of sexual development in the opossum by sex hor- mones. Proc. Soc. Exp. Biol. Med., 40:544-46. Gonadotropic substances and male hormone effects in the organism. J. Urol., 42: 1251-64. 1940 Physiology of the testes and therapeutic application of male hor- mone. Bulletin of the New York Academy of Medicine, 16: 135- 52. The biologic background of human reproduction. In: Obstetrics and Gynecology, Vol. 1, ed. by F. L. Adair, pp. 47-72. Phila- delphia, Lea and Febiger. The testis hormone. In: The Cyclopaedia of Medicine, Vol. 14, pp. 932-37. Philadelphia, F. A. Davis Company. With D. Bodian. Opossum pouch young as experimental material. Anat. Record, 76: 319-27. 1941 On the role of sex hormones in sex differentiation in the opossum (`Didelphys virginiana). Physiol. Zool., 14:1-47. Physiology of the testis. i. Am. Med. Assoc., 116:1638-44. Effects of testosterone propionate on embryonic ducts in the rat.
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410 BIOGRAPHICAL MEMOIRS Archives Internationales de Pharmacodynamie et de Therapie, 65:365-71. Embryonic differentiation of opossum prostate following castration, and responses of the juvenile gland to hormones. Anat. Record, 80:315-26. The influence of hormones on the development of the reproductive system. J. Urol., 45: 869-74. 1942 The physiology of the testis and application of male sex hormone. J. Ural., 47:31-44. Physiology of the testis. 2d ea., pp. 233-51 With C. F. Morgan. In: Glandular Physiology and Therapy' Chicago, Am. Medical Assn. Responses of testis to androgenic treatments. Endocrinology, 30:990-99. With D. Price. Differentiation of embryonic reproductive tissues of the rat after transplantation into post-natal hosts. J. Exp. Zool., 90:229-65. Comparative biology of testicular and ovarian hormones. Bio- logical Symposia, 9:3-10. 1943 With C. F. Morgan. First response of developing opossum gonads to equine gonadotropin treatment. Endocrinology, 32:17-26. Sexual differentiation in the opossum after early gonadectomy. l. Exp. Zool., 94:415-58. 1944 Gonad hormones and sex differentiation. 130. Am. Naturalist, 78: 97- Sex endocrines in development and prepuberal life. i. Clin. Endocrinol., 4: 135-41. Hormone secretion by experimental cryptorchid testes. Yale Jour- nal of Biology and Medicine, 17: 203-16. 1945 Prostate gland induction in the female opossum by hormones and the capacity of the gland for development. Am. J. Anat., 76:1- 28.
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CARL RICHARD MOORE 1946 411 With E. A. Failor. The role of sex hormones in the origin and development of uterine glands in the opossum. i. Exp. Zool., 102: 209-35. 1947 With H. Wang. Ovarian activity in mammals subsequent to chem- ical injury of cortex. Physiol. Zool., 20:300-20. Embryonic Sex Hormones and Sexual Differentiation. Monograph in: American Lectures in Endocrinology, ed. by W. O. Thomp- son. Springfield, Charles C Thomas, Publishers. v + 81 pp. With D. Price. Reproduction at high altitudes. Anat. Record, 99:574. (A) 1948 Frank Rattray Lillie 1870-1947. Record, 101: 1 -4. With D. Price. A study at high altitude of reproduction, growth, sexual maturity, and organ weights. J. Exp. Zool., 108: 171-216. Science, 107:33-35; also in Anat. 1949 Androgens and growth phenomena. Proceedings 1st National Can- cer Conference, pp. 67-73. 1950 Reconsiderations of the influence of genetic factors and steroid hormones in sex differentiation. In: A Symposium on Steroid Hormones' ed. by E. S. Gordon, pp. 393-96. Madison, Univer- sity of Wisconsin Press. The role of fetal endocrine glands in development. J. Clin. En- docrinol., 10: 942-85. Studies on sex hormones and sexual differentiation in mammals. Archives d'Anatomie )/licroscopique et de Morphologic Experi- mentale, 39:484-94. 1951 Experimental studies on the male reproductive system. l. Urol. 65:497-506.
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412 BIOGRAPHICAL OILS 1952 Biologic background of male sterility. Fertility and Sterility,3:433- 60. 1938 Adrenal cortical secretions in relation to the reproductive system of rate ]ourna1 of Clinical Endocrinology and )letabol~ m, 13:330-68. 1934 Physiology oftbetesUs end scrotum. In: ~ro/~>,ed.by Hi. Camp- beD, pp. 123-41. Philadelphia Ad. B. Saunders Cam pang.
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