TABLE 4-10 Case Reports of Milk Alkali Syndrome (single dose/day) a

Studies

Ca Intake (g/d) b

Duration

Mitigating Factors

Abreo et al., 1993

9.6c

>3 mo

None reported

 

3.6c

>2 y

None reported

 

10.8d

Not stated

None reported

Brandwein and Sigman, 1994

2.7c

2 y, 8 mo

None reported

Bullimore and Miloszewski, 1987

6.5d

23 y

Alkali in antacid

Campbell et al., 1994

5d

3 mo

None reported

Carroll et al., 1983

4.2d

30 y

None reported

 

2c

5 y

None reported

 

3.8d

2 mo

Vitamins A and E

 

2.8d

10 y

NaHCO3, 5 g/d

French et al., 1986

8c

2 y

None reported

 

4.2c

>2 y

Thiazide

Gora et al., 1989

4c

2 y

Thiazide

Hart et al., 1982

10.6d

Not stated

NaHCO3, 2 g/d

Kallmeyer and Funston, 1983

8d

10 y

Alkali in antacid

Kapsner et al., 1986

10d

10 mo

None reported

 

6.8d

7 mo

None reported

 

4.8c

2 d

10-y history of antacid use

Kleinman et al., 1991

16.5d

2 wk

10-y history of antacid use

Lin et al., 1996

1.5c

4 wk

None reported

Muldowney and Mazbar, 1996

1.7c

13 mo (52 wk)

None reported

Schuman and Jones, 1985

9.8d

20 y

None reported

 

4.8d

6 wk

10-y history of antacid intake

Whiting and Wood, 1997

2.4c

>1 y

None reported

Whiting and Wood, 1997

2.3–4.6c

>1 y

None reported

Number of Subjects

26

   

Mean

5.9

3 y, 8 mo

 

Median

4.8

13 mo

 

Range

1.5–>16.5

2 d–23 y

 

a Case reports of patients with renal failure are not included in this table.

b Intake estimates provided by Whiting and Wood (1997).

c Calcium intake from supplements only.

d Calcium intake from supplements and diet.



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