TABLE 4-1 Randomized Controlled Calcium Intervention Trials in Postmenopausal Women

 

Calcium Intake (mg/day)

Relative Change in BMD or BMC in Calcium Group Compared with Placebo

 

Site

N

Diet

Supplementa

Year 1

Year 2 or More, Annualized

Statistically Significant Change in BMD or BMC in Calcium Group Compared with Placebo

Spine

Early postmenopausal

Aloia et al., 1994b

70

500

1,700

Pj

S or N

no

Dawson-Hughes et al., 1990

67

<400

500

Sh or N i

S

no

Elders et al., 1991d

248

1,150

1,000 and 2,000

P

S or N

yes

Riis et al., 1987

25

~1,000c

2,000

P

S or N

no

Late Menopausal

Dawson-Hughes et al., 1990

169

<400

500 (CCM)

P

S or N

yes

     

500 (CC)

P

S or N

no

   

400–

500 (CCM)

P

S or N

no

   

650

500 (CC)

S or N

S or N

no

Prince et al., 1995

126

800

1,000

P

S or N

no

Reid et al., 1995

78

750

1,000

P

S or N

yes

Radius (Proximal)

Early postmenopausal

Aloia et al., 1994b

70

500

1,700

S or N

P

no

Dawson-Hughes et al., 1990

67

<400

500

P

P

no

Prince et al., 1991e

80

800

1,000

P

P

no

Riis et al., 1987

25

~1,000

2,000

P

P

yes

Late postmenopausal

Dawson-Hugheset al., 1990

169

<400

500 (CCM)

P

P

yes

     

500 (CC)

P

S or N

yes

   

400–650

500 (CCM)

P

P

no

     

500 (CC)

P

P

no

Recker et al., 1996:

Prevalent vertebral fracture group

94

~450

1,200 (CC)

yes

Non-prevalent vertebral fracture group

99

~450

1,200 (CC)

no



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement