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Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability (1997)
Institute of Medicine (IOM)

Page
359
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Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability

V
Discussion

GILBERT LEVEILLE: This is just a reaction. I thought it was a very exciting day. For those of us who have been away from the bench for a long time, it is exciting to see what is happening. The intriguing things to me are how the technology is evolving, and the tremendous number of things we can do with much greater efficiency than we could ever do them before.

Still, the issue that remains is the basic fundamental question that one poses to be answered with the new technology. It is interesting to look at the basic biochemistry that we are now able to explore in noninvasive ways, or at least with minimal invasion. But we still are playing the same tracer games when we chase a few carbons around a metabolic cycle, this is still fun, but I think it still leads us back to what questions we really want to ask.

Someone raised the question of whether what we really need to look at is what is happening at the membrane level and what impact that is having at the total organism level. Clearly that is an important question that we have not addressed, and we need to get to it.

Page
359
Front Matter (R1-R18)
I Committee Summary and Recommendations (1-2)
1 Project Overview and Committee Summary (3-50)
2 Committee Responses to Questions, Conclusions and Recommendations (51-68)
II The Current Army Program and Its Future Needs (69-70)
3 Emerging Technologies in Nutrition Research for the Military: Overview of the Issues (71-78)
III Techniques of Body Composition Assessment (79-80)
4 Military Application of Body Composition Assessment Technologies (81-126)
5 Imaging Techniques of Body Composition: Advantages of Measurement and New Uses (127-150)
6 Dual-Energy X-Ray Absorptiometry: Research Issues, and Equipment (151-168)
7 Bioelectrical Impedance: A History, Research Issues, and Recent Consensus (169-192)
Part III Discussion (193-198)
IV Tracer Techniques for the Study of Metabolism (199-200)
8 Stable Isotope Tracers: Technological Tools That Have Emerged (201-214)
9 Measurement of Energy Substrate Metabolism Using Stable Isotopes (215-230)
10 Combined Stable Isotope-Positron Emission Tomography for In Vivo Assessment of Protein Metabolism (231-258)
11 Nuclear Magnetic Resonance Studies of Liver and Muscle Glycogen Metabolism in Humans (259-272)
Part IV Discussion (273-278)
V Ambulatory Techniques for Measurement of Energy Expenditure (279-280)
12 Doubly Labeled Water for Energy Expenditure (281-296)
13 Measurement of Oxygen Uptake with Portable Equipment (297-314)
14 Advances in Ambulatory Monitoring: Using Foot Contact Time to Estimate the Metabolic Cost of Locomotion (315-344)
15 Noninvasive Measurement of Plasma Metabolites Using Near-Infrared Spectroscopy (359-360)
Part V Discussion (361-362)
VI Molecular and Cellular Approaches to Nutrition (363-374)
16 The Role of Metals in Gene Expression (375-388)
17 Metabolic Regulation of Gene Expression (389-400)
18 Use of Isolated-Cell and Metabolic Techniques Applied to Vitamin Transport and Disposition (401-414)
19 Assessment of Cellular Dysfunction During Physiologic Stress (415-416)
VII Assessment of Immune Function (417-430)
20 The Validity of Blood and Urinary Cytokine Measurements for Detecting the Presence of Inflammation (431-450)
21 New Approaches to the Study of Abnormal Immune Function (451-500)
Part VI and VII Discussion (501-504)
VIII Functional and Behavioral Measures of Nutritional Status (505-506)
23 Involuntary Muscle Contraction to Assess Nutritional Status (507-518)
24 Application of Cognitive Performance Assessment Technology to Military Nutrition Research (519-532)
25 New Techniques for Assessment of Mental Performance in the Field (533-550)
26 The Iowa Driving Simulator: Using Simulation for Human Performance Measurement (551-568)
Part VIII Discussion (569-576)
Appendixes (577-578)
Appendix A: Workshop Agenda (579-584)
Appendix B: Biographical Sketches (585-604)
Appendix C: Abbreviations (605-608)
Appendix D: Emerging Technologies for Nutrition Research - A Selected Biography (609-680)
Index (681-711)

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OCR for page 359
Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability V Discussion GILBERT LEVEILLE: This is just a reaction. I thought it was a very exciting day. For those of us who have been away from the bench for a long time, it is exciting to see what is happening. The intriguing things to me are how the technology is evolving, and the tremendous number of things we can do with much greater efficiency than we could ever do them before. Still, the issue that remains is the basic fundamental question that one poses to be answered with the new technology. It is interesting to look at the basic biochemistry that we are now able to explore in noninvasive ways, or at least with minimal invasion. But we still are playing the same tracer games when we chase a few carbons around a metabolic cycle, this is still fun, but I think it still leads us back to what questions we really want to ask. Someone raised the question of whether what we really need to look at is what is happening at the membrane level and what impact that is having at the total organism level. Clearly that is an important question that we have not addressed, and we need to get to it.

OCR for page 360
Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability This page in the original is blank.

Representative terms from entire chapter:

total organism