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PAPERBACK price:$34.75 add to cart Rights & Permissions Free PDF Access Sign in to download PDF book and chapters Free Resources PDF SUMMARY Display this book on your site! Related Titles Adverse Effects of Vaccines: Evidence and Causality The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies Other Related Titles Vaccine Safety Forum: Summaries of Two Workshops (1997) Institute of Medicine (IOM) Citation Manager Export the bibliographic data for this book in your chosen format Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Citation Manager . "EXECUTIVE SUMMARY." Vaccine Safety Forum: Summaries of Two Workshops. Washington, DC: The National Academies Press, 1997. Please select a format: Page 29   E-mail Share on facebook Facebook Share on delicious Delicious Share on stumbleupon Stumble Share on twitter Twitter More Sharing ServicesMore The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. Research to Identify Risks for Adverse Events Following Vaccination: Biological Mechanisms and Possible Means of Prevention Cynthia J. Howe, Richard B. Johnston, and E. Russell Alexander, Editors EXECUTIVE SUMMARY On April 1, 1996, the Vaccine Safety Forum convened a workshop entitled Research to Identify Risks for Adverse Events Following Vaccination: Mechanisms and Possible Means of Prevention. The workshop discussed the various immunologic and genetic factors that might influence individuals' responses to vaccines, current research aimed at assessing what populations are at increased risk for experiencing adverse events from vaccines, and research avenues that could be pursued in this regard. This document represents a summary of that workshop. As discussed at the workshop, a number of immunologic and genetic variables are likely to foster diverse responses to vaccines. Certain populations may be more susceptible to adverse events following vaccination because of some of these variables. Studies aimed at assessing which groups of individuals may be at most risk for experiencing adverse events from specific vaccines were also addressed. These studies include those that examine the potential link between the following: arthritis and rubella vaccine; anaphylaxis and the measles, mumps, and rubella vaccine; convulsions and the diphtheria and tetanus toxoids and pertussis vaccine (DPT); high-titer measles vaccines and mortality; multiple sclerosis or Guillain-Barré syndrome and vaccination; multiple-antigen vaccinations and adverse events; and adverse events following vaccinations among premature infants. Page 29 FRONT MATTER (R1-R8) EXECUTIVE SUMMARY (1-1) INTRODUCTION (2-2) DIFFICULTIES IN DETECTING ADVERSE EVENTS FOLLOWING VACCINATION (3-4) CURRENT ADVERSE EVENT DETECTION AND RESPONSE PROCEDURES (5-8) IMPROVING DETECTION OF AND RESPONSE TO ADVERSE EVENTS (9-17) ADDITIONAL AREAS FOR RESEARCH (18-20) REFERENCES (21-22) WORKSHOP AGENDA (23-28) EXECUTIVE SUMMARY (29-29) INTRODUCTION (30-30) IMMUNE RESPONSE TO VACCINE ANTIGENS (31-34) GENETIC FACTORS AFFECTING DEVELOPMENT OF AUTOIMMUNITY (35-36) RESEARCH ON IDENTIFYING POPULATIONS AT RISK FOR ADVERSE EVENTS (37-43) RESEARCH OPPORTUNITIES (44-50) REFERENCES (51-56) WORKSHOP AGENDA (57-63)

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Vaccine Safety Forum: Summaries of Two Workshops Research to Identify Risks for Adverse Events Following Vaccination: Biological Mechanisms and Possible Means of Prevention Cynthia J. Howe, Richard B. Johnston, and E. Russell Alexander, Editors EXECUTIVE SUMMARY On April 1, 1996, the Vaccine Safety Forum convened a workshop entitled Research to Identify Risks for Adverse Events Following Vaccination: Mechanisms and Possible Means of Prevention. The workshop discussed the various immunologic and genetic factors that might influence individuals' responses to vaccines, current research aimed at assessing what populations are at increased risk for experiencing adverse events from vaccines, and research avenues that could be pursued in this regard. This document represents a summary of that workshop. As discussed at the workshop, a number of immunologic and genetic variables are likely to foster diverse responses to vaccines. Certain populations may be more susceptible to adverse events following vaccination because of some of these variables. Studies aimed at assessing which groups of individuals may be at most risk for experiencing adverse events from specific vaccines were also addressed. These studies include those that examine the potential link between the following: arthritis and rubella vaccine; anaphylaxis and the measles, mumps, and rubella vaccine; convulsions and the diphtheria and tetanus toxoids and pertussis vaccine (DPT); high-titer measles vaccines and mortality; multiple sclerosis or Guillain-Barré syndrome and vaccination; multiple-antigen vaccinations and adverse events; and adverse events following vaccinations among premature infants.

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