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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)
Institute of Medicine (IOM)

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. "Summary." Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press, 1998.

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DRI Dietary Reference Intakes: For Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

(AI). Like all chemical agents, nutrients can produce adverse effects if intakes are excessive. Therefore, when data are extremely limited, extra caution may be warranted.

USING DIETARY REFERENCE INTAKES TO ASSESS THE NUTRIENT INTAKE OF GROUPS

For statistical reasons that will be addressed in a future report, the Estimated Average Requirement (EAR) is greatly preferred over the Recommended Dietary Allowance (RDA) for use in assessing the nutrient intake of groups. Table S-1 shows, for example, that fewer than 5 percent of young men have dietary intakes of thiamin, riboflavin, niacin, or vitamin B12 that are less than the EARs for these nutrients. This indicates that dietary intake of these five B vitamins by young men has a high probability of being sufficient to meet their needs. A large proportion of the individuals in the population, especially women, reportedly has a total folate intake less than the EAR. However, because the reported folate content of foods is considered to be substantially underestimated (in part because of methodological problems, content not being reported in dietary folate equivalents, and data being obtained before the fortification of cereal grains was required), it is not known to what extent this discrepancy between the EAR and intake represents a problem.

The determination of ways to increase dietary intake of a nutrient should include examination of the foods that are the major contributors of the nutrient to the U.S. or Canadian diet and the specific foods that are rich in the nutrient. U.S. data on both are provided in this report.

HOW TO MEET RECOMMENDED DIETARY ALLOWANCES OR ADEQUATE INTAKES

A primary question that must be answered is How can individuals consume the Recommended Dietary Allowance (RDA) or Adequate Intake (AI) if surveys indicate that typical diets contain lower amounts? This becomes a policy issue with regard to choosing methods to increase consumption of that nutrient in order to decrease the number of individuals at risk because of inadequate dietary intakes. Such methods include educating consumers to change their food consumption behavior, fortifying foodstuffs with the nutrient, providing dietary supplements, or a combination of the three methods. It is not the function of this report, given the scope of work outlined, to provide an analysis of the impact of using these three methods.

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Front Matter (R1-R24)
Summary (1-16)
1 Introduction to Dietary Reference Intakes (17-26)
2 The B Vitamins and Choline: Overview and Methods (27-40)
3 A Model for the Development of Tolerable Upper Intake Levels (41-57)
4 Thiamin (58-86)
5 Riboflavin (87-122)
6 Niacin (123-149)
7 Vitamin B6 (150-195)
8 Folate (196-305)
9 Vitamin B12 (306-356)
10 Pantothenic Acid (357-373)
11 Biotin (374-389)
12 Choline (390-422)
13 Uses of Dietary Reference Intakes (423-436)
14 A Research Agenda (437-442)
A Origin and Framework of the Development of Dietary Reference Intakes (443-447)
B Acknowledgments (448-450)
C Système International d'Unités (451-452)
D Search Strategies (453-455)
E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins (456-459)
F Dietary Intake Data from the Boston Nutritional Status Survey, 1981–1984 (460-465)
G Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994–1995 (466-477)
H Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (478-501)
I Daily Intakes of B Vitamins by Canadian Men and Women, 1990, 1993 (502-506)
J Options for Dealing with Uncertainties in Developing Tolerable Upper Intake Levels (507-511)
K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (512-519)
L Methylenetetrahydrofolate Reductase (520-522)
M Evidence from Animal Studies on the Etiology of Neural Tube Defects (523-526)
N Estimation of the Period Covered by Vitamin B12 Stores (527-530)
O Biographical Sketches (531-536)
P Glossary and Abbreviations (537-540)
Index (541-567)