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TABLE 8-7 Observational Studies of Folate and Risk of Neural Tube Defect

Study

Design

Subjects

Mulinare et al., 1988 (as reported in CDC, 1992)

Case/control in metropolitan Atlanta

NTDa case infants and normal control infants

Pregnant women without a prior NTD-affected pregnancy

Bower and Stanley, 1989 (as reported in CDC, 1992)

Case/control in Western Australia

Spina bifida case infants and normal control infants

Pregnant women without a prior NTD-affected pregnancy

Mills et al., 1989 (as reported in CDC, 1992)

Case/control in California and Illinois

NTD case infants and normal control infants

Pregnant women without a prior NTD-affected pregnancy

Milunsky et al., 1989 (as reported in CDC, 1992)

Prospective cohort in New England

NTD case infants and normal control infants

Pregnant women without a prior NTD-affected pregnancy



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