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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)
Institute of Medicine (IOM)

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. "2 The B Vitamins and Choline: Overview and Methods." Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press, 1998.

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DRI Dietary Reference Intakes: For Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

weighing 70 kg would require—a higher percentage than that represented by actual weight.

  1. The EAR for adults is an estimate of maintenance needs.

  2. The percentage of extra B vitamins and choline needed for growth is comparable with the percentage of extra protein needed for growth.

  3. On average, total needs do not differ substantially for males and females until age 14, when reference weights differ.

The formula for the extrapolation is

EARchild = EARadult (F),

where F = (Weightchild/Weightadult)0.75 (1 + growth factor). Reference weights from Table 1-2 are used. If the EAR differs for men and women, the reference weight used for adults differs by gender; otherwise, the average for men and women is used unless the value for women is derived from data on men. The approximate proportional increase in protein requirements for growth (FAO/WHO/ UNA, 1985) is used as an estimate of the growth factor as shown in Table 2-1. If only an AI has been set for adults, it is substituted for the EAR in the above formula and an AI is calculated; no RDA will be set.

Setting the RDA

To account for variability in requirements because of growth rates and other factors, a 10 percent coefficient of variation (CV) for the

TABLE 2-1 Growth Factors Used to Extrapolate DRIs

Age Group

Growth Factor

7 mo–3 y

0.30

4–8 y

0.15

9–13 y

0.15

14–18 y, Males

0.15

14–18 y, Females

0.00

NOTE: Growth beyond age 13 for females is assumed to represent a negligible increased requirement for vitamins.

SOURCE: The proportional increase in protein requirements for growth from FAO/ WHO/UNA (1985) was used to estimate the growth factor indicated.

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Front Matter (R1-R24)
Summary (1-16)
1 Introduction to Dietary Reference Intakes (17-26)
2 The B Vitamins and Choline: Overview and Methods (27-40)
3 A Model for the Development of Tolerable Upper Intake Levels (41-57)
4 Thiamin (58-86)
5 Riboflavin (87-122)
6 Niacin (123-149)
7 Vitamin B6 (150-195)
8 Folate (196-305)
9 Vitamin B12 (306-356)
10 Pantothenic Acid (357-373)
11 Biotin (374-389)
12 Choline (390-422)
13 Uses of Dietary Reference Intakes (423-436)
14 A Research Agenda (437-442)
A Origin and Framework of the Development of Dietary Reference Intakes (443-447)
B Acknowledgments (448-450)
C Système International d'Unités (451-452)
D Search Strategies (453-455)
E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins (456-459)
F Dietary Intake Data from the Boston Nutritional Status Survey, 1981–1984 (460-465)
G Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994–1995 (466-477)
H Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (478-501)
I Daily Intakes of B Vitamins by Canadian Men and Women, 1990, 1993 (502-506)
J Options for Dealing with Uncertainties in Developing Tolerable Upper Intake Levels (507-511)
K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (512-519)
L Methylenetetrahydrofolate Reductase (520-522)
M Evidence from Animal Studies on the Etiology of Neural Tube Defects (523-526)
N Estimation of the Period Covered by Vitamin B12 Stores (527-530)
O Biographical Sketches (531-536)
P Glossary and Abbreviations (537-540)
Index (541-567)