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TABLE 9-6 Other Studies of Subjects with Pernicious Anemia Considered in Setting the Estimated Average Requirement for Vitamin B12 for Adults

Reference

Number of Subjects

Age Range (y)

Suggested IMa requirement > 2.0 µg

Hansen and Weinfeld, 1962

14

 

Suggested IM requirement of 1.0–2.0 µg

Bastrup-Madsen et al., 1983

112

33–78

Lindenbaum et al., 1990

44

NAc

Other Studies

Best et al., 1956

6

NA

Will et al., 1959

40

NA

Sullivan and Herbert, 1965

8

46–86

a IM = intramuscular.

b 1,000 µg × 0.15 retention/90 d.

c NA = not available.

d 1,000 µg × 0.15 retention/182 d.



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