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infants ages 0 through 6 months is based on the reported mean volume of milk consumed by this age group (0.78 L/day; see Chapter 2) and the estimate of the biotin concentration in human milk of 6 µg/L (0.78 L × 6 µg/L = 5

Ages 7 through 12 Months. If the reference body weight ratio method described in Chapter 2 to extrapolate up from the AI for biotin for infants ages 0 through 6 months is used, the AI for biotin for the older infants is 6 µg/day after rounding.

Biotin AI Summary, Ages 0 through 12 Months

AI for Infants

0–6 months

5 µg/day of biotin

≈0.7 µg/kg

7–12 months

6 µg/day of biotin

≈0.7 µg/kg

Children and Adolescents Ages 1 through 18 Years

Method Used to Set the AI

Evidence concerning the biotin requirement is minimal and does not justify the setting of an Estimated Average Requirement (EAR). No definitive studies demonstrate evidence of biotin deficiency in normal individuals in any age group resulting from inadequate intakes. In the absence of additional information, including data on needs of adults, AIs for children and adolescents have been extrapolated from values for infants by using the formula

AIchild = (AIyounginfant) (weightchild/weightinfant)0.75.

Biotin AI Summary, Ages 1 through 18 Years

AI for Children

1–3 years

8 µg/day of biotin

4–8 years

12 µg/day of biotin

AI for Boys

9–13 years

20 µg/day of biotin

14–18 years

25 µg/day of biotin

AI for Girls

9–13 years

20 µg/day of biotin

14–18 years

25 µg/day of biotin



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