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Folate

B12

Pantothenic Acid

Biotin

Choline

Needs improvement

Yes

Needs improvement

Being improved

Yes

Good, but incomplete assays for all forms

Fair; some metabolite interference noted

Needs improvement

Variable

Mass spectrometry specific to 5 pmol

No, see Gunter et al., 1996a

No, e.g., Euglena gracilis gives lower values than does Lactobacillis leichmannii

Fair, limited

No

Yes

No, see Gunter et al., 1996a

No, nonisotopic and radioassays do not agree closely

Fair

Fair, limited

Yes

Trends vary depending on method.

Radioassays were unreliable before 1978. Recent introduction of nonisotopic assays has led to higher results.

Little change in methods

Generally lower now

No change



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