Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)
Institute of Medicine (IOM)

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. "E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins." Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press, 1998.

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DRI Dietary Reference Intakes: For Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

Folate	B₁₂	Pantothenic Acid	Biotin	Choline
Needs improvement	Yes	Needs improvement	Being improved	Yes
Good, but incomplete assays for all forms	Fair; some metabolite interference noted	Needs improvement	Variable	Mass spectrometry specific to 5 pmol
No, see Gunter et al., 1996^a	No, e.g., Euglena gracilis gives lower values than does Lactobacillis leichmannii	Fair, limited	No	Yes
No, see Gunter et al., 1996^a	No, nonisotopic and radioassays do not agree closely	Fair	Fair, limited	Yes
Trends vary depending on method.	Radioassays were unreliable before 1978. Recent introduction of nonisotopic assays has led to higher results.	Little change in methods	Generally lower now	No change

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Front Matter (R1-R24)

1 Introduction to Dietary Reference Intakes (17-26)

2 The B Vitamins and Choline: Overview and Methods (27-40)

3 A Model for the Development of Tolerable Upper Intake Levels (41-57)

4 Thiamin (58-86)

5 Riboflavin (87-122)

6 Niacin (123-149)

7 Vitamin B6 (150-195)

8 Folate (196-305)

9 Vitamin B12 (306-356)

10 Pantothenic Acid (357-373)

11 Biotin (374-389)

12 Choline (390-422)

13 Uses of Dietary Reference Intakes (423-436)

14 A Research Agenda (437-442)

A Origin and Framework of the Development of Dietary Reference Intakes (443-447)

B Acknowledgments (448-450)

C Système International d'Unités (451-452)

D Search Strategies (453-455)

E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins (456-459)

F Dietary Intake Data from the Boston Nutritional Status Survey, 1981–1984 (460-465)

G Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994–1995 (466-477)

H Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (478-501)

I Daily Intakes of B Vitamins by Canadian Men and Women, 1990, 1993 (502-506)

J Options for Dealing with Uncertainties in Developing Tolerable Upper Intake Levels (507-511)

K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (512-519)

L Methylenetetrahydrofolate Reductase (520-522)

M Evidence from Animal Studies on the Etiology of Neural Tube Defects (523-526)

N Estimation of the Period Covered by Vitamin B12 Stores (527-530)

O Biographical Sketches (531-536)

P Glossary and Abbreviations (537-540)

Index (541-567)