NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance.

This report has been prepared with funds provided by the Department of Energy, Grant No. DE-FG02-94ER61939 and the National Cancer Institute, Contract No. N01-OD-4-2139 (Task Order 33).