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Appendix B
Workshop Agendas

Workshop on Perspectives on the Medical Use of Marijuana:
Basic and Clinical Science

December 14-16, 1997 Beckman Center, Irvine, California

AGENDA

Sunday, December 14,1997

2:00 p.m.  Introduction
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health

2:30 p.m.  Public Input Session, 5 minutes per person
Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan

5:30 p.m.  ADJOURN



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OCR for page 232
Page 232 Appendix B Workshop Agendas Workshop on Perspectives on the Medical Use of Marijuana: Basic and Clinical Science December 14-16, 1997 Beckman Center, Irvine, California AGENDA Sunday, December 14,1997 2:00 p.m.  Introduction Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health 2:30 p.m.  Public Input Session, 5 minutes per person Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan 5:30 p.m.  ADJOURN

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Page 233 Monday, December 15, 1997 CANNABINOID NEUROSCIENCE 8:30 a.m.  Moderator: Stanley Watson, IOM Study Investigator, University of Michigan 8:45 a.m.  Neuropharmacology of Cannabinoids and Their Receptors Steven R. Childers, Wake Forest University School of Medicine 9:15 a.m.  Precipitated Cannabinoid Withdrawal and Sensory Processing of Painful Stimuli J. Michael Walker, Brown University 9:45 a.m.  Role of Cannabinoids in Movement Clara Sanudo, Brown University 10:15 a.m. Tolerance and Cannabinoid-Opioid Interactions Sandra P. Welch, Medical College of Virginia 10:45 a.m. BREAK MEDICAL USES OF MARIJUANA: CLINICAL DATA AND BASIC BIOLOGY 11:10 a.m. Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University 11:15 a.m. Profile of Medical Marijuana Users John Mendelson, University of California at San Francisco 11:45 a.m. Immune Modulation by Cannabinoids Norbert Kaminski, Michigan State University 12:15 p.m. Psychological Effects of Marijuana Use Charles R. Schuster, Wayne State University 12:45 p.m. LUNCH

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Page 234 1:45 p.m.  Marijuana and Glaucoma Paul Kaufman, University of Wisconsin 2:15 p.m.  Effects of Marijuana and Cannabinoids in Neurological Disorders Paul Consroe, University of Arizona Health Sciences Center 2:45 p.m.  Neural Mechanisms of Cannabinoid Analgesia Howard Fields, University of California at San Francisco 3:15 p.m. Pain Management Michael Rowbotham, University of California at San Francisco 3:45 p.m.  Wasting Syndrome Pathogenesis and Clinical Markers Donald Kotler, St. Luke's-Roosevelt Hospital 4:15 p.m.  Clinical Experience with Marijuana Stephen O'Brien, East Bay AIDS Center 4:45 p.m. ADJOURN Tuesday, December 16,1997 MEDICAL USES OF MARIJUANA: CLINICAL DATA AND BASIC BIOLOGY 8:30 a.m.  Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University 8:45 a.m.  Marijuana in AIDS Wasting: Tribulations and Trials Donald I. Abrams, University of California at San Francisco 9:15 a.m.  Nausea and Vomiting: Underlying Mechanisms and Upcoming Treatments Alan D. Miller, The Rockefeller University 9:45 a.m.  Postchemotherapy Nausea and Antiemetics Richard J. Gralla, Ochsner Cancer Center

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Page 235 10:15 a.m. BREAK SUMMARY VIEWS 10:30 a.m. Marijuana Is Different from THC: A Review of Basic Research and State Studies of Antiemesis Richard E. Musty, University of Vermont 11:00 a.m. Medical Uses of Crude Marijuana: Medical and Social Issues Eric A. Voth, The International Drug Strategy Institute 11:30 a.m. General Questions Moderator: John A. Benson, Jr., IOM Study Investigator 12:00 noon ADJOURN

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Page 236 Workshop on Acute and Chronic Effects of Marijuana Use January 22-23, 1998 New Orleans Marriott Hotel New Orleans, Louisiana AGENDA Thursday, January 22, 1998 2:00 p.m.  Introduction Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health 2:30 p.m.  Public Input Session, 5 minutes per person Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan 4:30 p.m. ADJOURN Friday, January 23, 1998 8:30 a.m.  Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University HEALTH CONSEQUENCES OF MARIJUANA USE 9:00 a.m.  Health Consequences of Marijuana Use: Epidemiological Studies Stephen Sidney, Kaiser Permanente, Oakland, CA 9:30 a.m.  Immunity, Infections, and Cannabinoids Thomas Klein, University of South Florida 10:00 a.m. Pulmonary Effects of Smoked Marijuana Donald Tashkin, Unversity of California at Los Angeles 10:30 a.m. BREAK

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Page 237 10:45 a.m. Is Marijuana Carcinogenic?: Epidemiological and Biological Evidence Panel Discussion Stephen Sidney Donald Tashkin 12:00 noon    LUNCH EFFECTS OF MARIJUANA ON BEHAVIOR 1:30 p.m.  Marijuana: Addictive and Amotivational States, the Scientific Evidence John Morgan, City University of New York Medical School 2:00 p.m.  Marijuana's Acute Behavioral Effects in Humans Richard Foltin, Columbia University 2:30 p.m.  Tolerance and Dependence Following Chronic Administration of Oral THC or Smoked Marijuana to Humans Margaret Haney, Columbia University 3:00 p.m.  Patterns of Continuity and Discontinuity of Marijuana Use in Relationship to Other Drugs Robert Pandina, Rutgers University 3:30 p.m.  ADJOURN

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Page 238 Workshop on Prospects for Cannabinoid Drug Development February 23-24, 1998 National Academy of Sciences Building Washington, D.C. AGENDA Monday, February 23,1998 1:30 p.m.  Introduction Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health 2:00 p.m.  Public Input Session, 5 minutes per person Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University 5:30 p.m.  ADJOURN Tuesday, February 24,1998 8:30 a.m.  Introduction Constance Pechura, IOM Division Director Neuroscience and Behavioral Health Moderator: Stanley J. Watson, Jr., IOM Study Investigator, University of Michigan OVERVIEWS OF PRECEDING WORKSHOPS 8:45 a.m.  Acute and Chronic Effects of Marijuana Billy R. Martin, Medical College of Virginia 9:25 a.m.  Perspectives on the Medical Use of Marijuana Eric B. Larson, University of Washington Medical School 9:55 a.m.  The Neurobiology of Cannabinoid Dependence George F. Koob, Scripps Research Institute 10:25 a.m. BREAK

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Page 239 DRUG DEVELOPMENT 10:45 a.m. Regulatory Requirements Affecting Marijuana J. Richard Crout, Crout Consulting 11:15 a.m. Marinol and the Market Robert E. Dudley, Unimed Pharmaceuticals, Inc. 11:45 a.m. Development of Cannabis-based Therapeutics Dave Pate, HortaPharm, B.V. 12:15 p.m. LUNCH DRUG DELIVERY 1:30 p.m.  Alternative Drug Delivery Technologies for the Therapeutic Use of Marijuana Phyllis I. Gardner, ALZA Corporation, Stanford University 2:00 p.m.  Delivery of Analgesics via the Respiratory Track Reid M. Rubsamen, Aradigm Corporation 2:30 p.m.  Current Concepts for Delivery of THC Mahendra G. Dedhiya, Roxanne Laboratories, Inc. 3:00 p.m.  D9-THC-Hemisuccinate in Suppository Formulation: An Alternative to Oral and Smoked THC Mahmoud A. ElSohly, University of Mississippi, ElSohly Laboratories, Inc. 3:30 p.m. Concluding Remarks John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University 3:45 p.m. ADJOURN