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OCR for page 449
OPPORTUNITIES IN BIOLOGY PLATES 1, 2 A repressor protein (from bacteriophage 434) is shown (left) approaching DNA and (right) bound to DNA in a crystal of the repressor-DNA complex. Ihis binding turns off expression of a bacteriophage gene. 1J. E. Anderson et al., Nature 326:846-852 (1987)] PLATE 3 Sites A-E on the surface protein of the flu virus are recognized by our immune system. Variation in the structure of these sites results in the recu''e'.ce of epidemics in the human population. [Based on work of D. Wiley, Harvard University, and J. Skehel, National Institute of Medical Research, London]

OCR for page 449
OPPORTUNITIES IN BIOLOGY PLATES 4, 5 Space-filling representation of Fab (antibody fragment containing antigen-binding sites) of an anti-lysozyme antibody and lysozyme. The antibody heavy chain is shown in blue, the light chain in yellow, lysozyme in green, and glutamine 121 of lysozyme in red. [A. G. Amit et al. Science 233:749 (1986), figure 2]