Drinking Water and Health, Volume 9 Selected Issues in Risk Assessment

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Drinking Water and Health, Volume 9 Selected Issues in Risk Assessment (1989)
Commission on Life Sciences (CLS)

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Front Matter (R1-R14)

Part I: DNA Adducts (1-2)

Executive Summary (3-5)

1 Biologic Significance of DNA Adducts and Protein Adducts (6-37)

2 DNA-Adduct Technology (38-56)

3 Conclusions and Recommendations (57-60)

Appendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA Adducts (61-78)

Glossary (79-88)

Biographical Sketches (89-92)

Part II: Mixtures (93-94)

Executive Summary (95-100)

1 Introduction (101-107)

2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants (108-120)

3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water (121-132)

4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates, and Volatile Organic Chemicals (133-145)

5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects (146-161)

6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals (162-167)

7 Conclusions and Recommendations for Research (168-170)

Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model (171-174)

Appendix B: A Model Illustrating Synergism (175-176)

Appendix C: Models of Response: Dose Additivity and Response Additivity (177-181)

Biographical Sketches (182-184)

Part III: Cumulative Index (185-186)

Index (187-268)