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Biographical Sketches
SUBCOMM ITTEE ON DNA ADDUCTS
DAVID if. BRUSICK received his Ph.D. in microbial genetics from
Illinois State University in 1970 and did postdoctoral research as a National
Academy of Sciences research associate at the Food and Drug Administra-
tion's Genetic Toxicology Branch. A past president of the U.S. Environ-
mental Mutagen Society (1978-79), Dr. Brusick is adjunct professor of
microbiology and genetics at the schools of medicine of both Howard and
George Washington universities. He is the author of numerous scientific
publications, including a textbook, Principles of Genetic Toxicology. He was
a committee member contributing to the NRC report Toxicity Testing: Strat-
egies to Determine Needs and Priorities for the National Toxicology Program
and has also served on numerous other NRC committees. He is a member
of the International Commission for the Protection against Environmental
Mutagens and Carcinogens and a member of the Steering Committee for the
Environmental Protection Agency's Gene-Tox Program. Dr. Brusick's in-
terests include basic and applied research in mutagenic and carcinogenic
mechanisms and the application of biotechnology techniques to the devel-
opment of safety testing methods.
GAIL T. ARCE is a genetic toxicologist at the Haskell Laboratory for
Toxicology and Industrial Medicine, E. I. du Pont de Nemours & Company,
in Newark, Delaware. She received her Ph.D. from Yale University in 1978
from the Department of Molecular Biophysics and Biochemistry and did
postdoctoral work at New York University's Department of Environmental
89
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90 DRINKING WATER AND HEALTH
Medicine and Columbia University's Institute of Cancer Research. Her re-
search has focused on the evaluation of DNA-adduct dosimetry in in vitro
mutation and transformation assays.
JOHN C. BAILAR III is a statistician and physician at McGill University
in Montreal. Since 1980 he has been a statistical consultant for the New
England Journal of Medicine. His research interests center on the processes
of health risk assessment, whether they are applied to chemicals, radiation,
microorganisms, or other hazards. He also has a strong interest in scientific
communication, and in 1987-88 served as the president of the Council of
Biology Editors. He has been a member of many National Academy of
Sciences/National Research Council studies concerned with health risks.
RAMESH C. GUPTA holds degrees from Agra, Meerut, and Roorkee
Universities in India. He is an associate professor in the Department of
Pharmacology at Baylor College of Medicine in Houston, Texas. Conducting
research in sensitive techniques for sequencing of RNA, he is also one of
the developers of the 32P-postlabeling assay for DNA adducts. His research
interests include DNA damage and repair in animal and human cells. Dr.
Gupta is a member of the American Society of Biological Chemists, the
American Society of Cancer Research, the American Society for Cell Bi-
ology, and the American Association for the Advancement of Science.
ROBIN HERBERT is a Charles A. Dana Foundation Fellow in Envi
ronmental Epidemiology and an instructor in the Division of Environmental
and Occupational Medicine of the Department of Community Medicine at
Mount Sinai Medical Center in New York, New York. An internist and
specialist in occupational medicine, Dr. Herbert's principal area of interest
is in the use of biologic markers of exposure to carcinogens in occupationally
and environmentally exposed populations. She is currently studying DNA
adducts and other markers of exposure among roofing workers exposed to
polycyclic aromatic hydrocarbons. Dr. Herbert is a member of the American
College of Physicians, the Society for General Internal Medicine, and the
American Public Health Association.
PAUL H. M. LOHMAN is a professor and director of the laboratory of
Radiation Genetics and Chemical Mutagenesis, State University of Leiden,
The Netherlands. Dr. Lohman is an expert is the field of DNA repair and
the relation between the induction of DNA damage, DNA repair, and mu-
tagenesis in cells of mammalian origin. Currently, he is heading one of the
largest research institutions in Europe in the filed of environmental muta-
genesis and genetic toxicology. He is scientific secretary of the International
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Biographical Sketches 91
Commission for Protection against Environmental Mutagens and Carcinogens
and a past president of the European Environmental Mutagen Society.
CAROL W. MOORE received degrees from Ohio State University and
Pennsylvania State University and performed postdoctoral research at the
University of Rochester School of Medicine. She received a fellowship to
conduct research in the Interdisciplinary Programs in Health and Environ-
mental Health Policy and Management Program from the Harvard University
School of Public Health and School of Business. Dr. Moore is currently
associate professor of microbiology at City University of New York Medical
School, Sophie Davis School of Biomedical Education City College, New
York City. She has conducted research in genetics, molecular biology, ge-
netic toxicology, cancer biology, radiobiology and biochemistry, including
the genetic control of cellular responses in yeast and human cells to radiation
and the radiomimetic bleomycins.
ROBERT F. MURRAY is a graduate of the University of Rochester
School of Medicine, an internist whose subspecialty is medical genetics. A
military tour of duty in the U.S. Public Health Service at the National
Institutes of Health sparked an interest in genetic markers which might in-
dicate inherited susceptibility to disease. He received a master's degree and
a fellowship in medical genetics at the University of Washington in Seattle.
After joining the Faculty of Medicine at Howard University in Washington,
D.C., he continued studies of developmental variation in human liver alcohol
dehydrogenase and genetic markers indicating the clonal origins of breast
tumors. He also became involved in programs of genetic screening, coun-
seling and prenatal diagnosis (with special emphasis on sickle cell disease),
and the use of genetic markers to identify individuals highly susceptible to
potentially toxic compounds in the work environment, as well as the effects
of these compounds on the human genome. A major research interest has
been the study of the psychological aspects of genetic counseling. He is
currently chief of the Division of Medical Genetics in the Department of
Pediatrics and Child Health, directing an active program of teaching and
patient service, and chairman of the Graduate Department of Genetics and
Human Genetics. He is an active member of the Institute of Medicine and
he has served on its governing council and also on several NRC and IOM
task forces and working groups.
MIRIAM C. POIRIER is a research chemist in the Laboratory of Cellular
Carcinogenesis and Tumor Promotion at the National Cancer Institute, NIH.
Her graduate studies were carried out at the McArdle Laboratories at the
University of Wisconsin, and the Department of Biology at the Catholic
University of America. She was among the first to elicit antisera specific for
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92 DRINKING WATER AND HEALTH
carcinogen-DNA adducts and investigate mechanisms of chemical carcino-
genesis utilizing quantitative immunoassays and immunohistochemistry. For
development of this methodology she received the NIH Merit Award. More
recently Dr. Poirier has pioneered efforts to validate the use of immunoassays
for human exposure biomonitoring. She has served in an advisory capacity
to the Harvard School of Public Health, the Department of Health and Human
Services Panel on Application of Biologic Markers in Risk Assessment, and
the Health Effects Institute.
GARY A. SEGA received graduate degrees from the University of Texas
and Louisiana State University. He has been a research staff member in the
Biology Division of Oak Ridge National Laboratory for the past 15 years.
Dr. Sega's principal research interest is studying the molecular mechanisms
that give rise to mutations in mammalian germ cells, including chemical
binding to DNA and proteins, and DNA repair in the germ cell. He is a
member of the Environmental Mutagen Society and is presently a member
of the editorial board of Molecular and Environmental Mutagenesis.
RICHARD B. SETLOW was educated in the field of physics (Ph.D.,
Yale University, 19471. He is a senior biophysicist at- Brookhaven National
Laboratory on Long Island and is the Laboratory's Associate Director for
Life Sciences. His research deals with DNA repair mechanisms in numerous
biological systems, the roles of such repair mechanisms in ameliorating the
effects of carcinogenic chemicals, variations in repair among people, and
the association of such mechanisms with aging. He is a member of the
National Academy of Sciences.
JAMES A. SWENBERG is head of-the Department of Biochemical
Toxicology and Pathobiology at the Chemical Industry Institute of Toxicology
and an adjunct professor of pathology at the University of North Carolina
and Duke University. Dr. Swenberg is on the editorial boards of several
cancer- and toxicology-related journals; served as a member and chairperson
of the National Toxicology Program Board of Scientific Counselors; is a
member of the EPA FIFRA Science Advisory Panel; and the Board of Sci-
entific Counselors, Division of Biometry and Risk Assessment of the National
Institute for Environmental Health Sciences. Dr. Swenberg's research inter-
ests address the role of DNA adducts, repair and replication in carcinogenesis,
experimental neuroncology and the scientific basis of quantitative risk as-
sessment. He is a diplomat in the American College of Veterinary Pathol-
ogists.
Representative terms from entire chapter:
dna repair
