. "4. Comparison of Disease Burdens." New Vaccine Development: Establishing Priorities: Volume II, Diseases of Importance in Developing Countries. Washington, DC: The National Academies Press, 1986.
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New Vaccine Development: Establishing Priorities, Volume II, Diseases of Importance in Developing Countries
TABLE 4.9 Morbidity and Mortality Burdens Resulting from Various Diseases
aSee Appendixes D-1 through D-19 for derivations of disease burden estimates used to calculate TDBVs.
bInfant mortality equivalence units.
cValues in parentheses represent the anticipated disease burden from certain diarrheal pathogens if a plausible increase in oral rehydration therapy is assumed (see Appendix C).
development is described in Appendixes D-1 through D-19. Various assumptions were entailed in deriving such estimates. Table 4.9 shows the total disease burden values calculated for each disease (using disease burden estimates and the median of perspectives from public health professionals in developing countries). Use of these total disease burden values to rank the diseases is demonstrated in Table 4.10.
Chapter 7 describes application of the disease comparison system to the calculation of potential health benefits from candidate vaccines.
LIMITATIONS OF THE PROPOSED SYSTEM
The proposed system assesses the most obvious feature of infectious diseases, morbidity, and mortality. The aggregate nature of the total
