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Monoclonal Antibody Production (1999)

Chapter: Appendix B: Biographical Sketches of Authoring Committee

« Previous: Appendix A: Workshop on Methods of Producing Monoclonal Antibodies
Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
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Appendix B
Biographical Sketches of Authoring Committee

Peter A. Ward, MD, Chairman

Dr. Ward is Professor and Chairman of the Department of Pathology of the University of Michigan Medical School. Dr. Ward received his MD from the University of Michigan in 1960 and has worked at Scripps, the Armed Forces Institute of Pathology, and the University of Connecticut Health Center. He has an extensive background in immunopathology, inflammation, and the biological role of complement and mechanisms of antibody formation. Dr. Ward is also a member of the Institute of Medicine.

Jane Adams, BA

Ms. Adams is Associate Director for Public Affair at the Juvenile Diabetes Foundation. Ms. Adams received her BA from University of Vermont. She has an extensive background in policy work and biomedical research. Ms. Adams has had type 1 diabetes since the age of 12.

Denise Faustman, MD, PhD

Dr. Faustman is Associate Professor of Medicine at Harvard Medical School and Director of Immunology Laboratories, Massachusetts General Hospital. Dr. Faustman received her MD and PhD from Washington University School of Medicine. She has an extensive background in the role of major histocompatibility complex in transplant rejection and role of defective antigen processing in autoimmunity.

Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
×

Gerald F. Gebhart, PhD

Dr. Gebhart is Professor and Head of the Department of Pharmacology at the University of Iowa College of Medicine. Dr. Gebhart received his PhD from the University of Iowa. He has an extensive background in pain and pain modulation and mechanisms of visceral pain and visceral hyperalgesia. Dr. Gebhart is also a member of ILAR Council.

James G. Geistfeld, DVM

Dr. Geistfeld is Director of Laboratory Animal Medicine at Taconic Farms and Vice President of Taconic Ventures. Dr. Geistfeld received his DVM from the University of Minnesota School of Veterinary Medicine. He has an extensive background in methods of producing monoclonal antibodies and methods of producing laboratory animals.

John W. Imbaratto, BS

Mr. Imbaratto is Manager of Cell Culture Manufacturing at Covance Biotechnology Services, Inc. in Research Triangle Park. Mr. Imbaratto received his BS from Kent State University in Ohio. He has worked in Quality Control and manufacturing since graduation, first as Head of Bacterial Fermentation and Toxoid Manufacturing for Lederle Laboratories, then as Manager of cGMP manufacturing of monoclonal antibodies using the mouse ascites method with Charles River Laboratories. Currently, he is with Covance Biotechnology Services as the Manager of Cell Culture Manufacturing providing in-vitro cGMP contract manufacturing services.

Norman C. Peterson, PhD, DVM

Dr. Peterson is a Research Associate in the Department of Clinical Studies at the University of Pennsylvania. Dr. Peterson received his DVM from the University of Illinois and his PhD from the University of Pennsylvania. His research involves investigations of oncogenic cell-surface receptor interactions and he has an extensive background in methods of producing monoclonal antibodies.

Fred Quimby, PhD, DVM

Dr. Quimby is Director of the Center for Laboratory Animal Resources at Cornell University, Ithaca. Dr. Quimby received his VMD and PhD from the University of Pennsylvania. He has an extensive background in immunology, differentiation antigens on canine lymphocytes, and immunologic abnormalities in autoimmune disease.

Ann Marshak-Rothstein, PhD

Dr. Rothstein is Professor of Microbiology and Director of Immunology Training Program at Boston University School of Medicine. Dr. Marshak-Rothstein received her PhD from University of Pennsylvania School of Medi-

Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
×

cine. She has an extensive background in cellular immunology, murine models of autoimmunity, autoantibody-medicated pathogenesis, and regulation of Fas/ FasL medicated apoptosis.

Andrew N. Rowan, DPhil

Dr. Rowan is Senior Vice President for the Humane Society of the United States. Dr. Rowan received his BA and DPhil from Oxford University. His research interests were initially the biochemistry of intermediary metabolism but he early became interested in the appropriate use of animals in research and in human interactions with, and attitudes towards, animals. He has written extensively on a variety of animal welfare issues including the mouse ascites method for producing monoclonal antibodies. He is currently focusing on how one might assess and minimize animal pain and distress in research animals.

Matthew D. Scharff, MD

Dr. Scharff is Professor of Cell Biology at Albert Einstein College of Medicine. Dr. Scharff received his MD from New York University College of Medicine. He has an extensive background in the basis for immunoglobulin variable region somatic hypermutation and isotope switching to discover better methods of producing monoclonal antibodies for treatment and prevention of disease. He is Co-Chair of the Board of Scientific Councilors and a member of the Executive Committee of the National Cancer Institute. Dr. Scharff is also a member of the National Academy of Sciences.

Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
×
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Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
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Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
×
Page 58
Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
×
Page 59
Suggested Citation:"Appendix B: Biographical Sketches of Authoring Committee." National Research Council. 1999. Monoclonal Antibody Production. Washington, DC: The National Academies Press. doi: 10.17226/9450.
×
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The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb.

In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method.

The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

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