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C Conference Agenda Conference on Resuscitation Fluid Design and Resuscitation Protocols for Combat Casualties National Academy of Sciences Auditorium 2101 Constitution Avenue, N.W. Washington, D.C. Thursday, September 17, 1998 8:30 a.m. WELCOMING REMARKS AND OVERVIEW OF THE CONFERENCE Clyde J. Behney Deputy Executive Officer Institute of Medicine Anna Johnson-Winegar, Ph.D. Head, Human Systems Department Office of Naval Research David E. Longnecker, M.D. Robert D. Dripps Professor and Chair Department of Anesthesia University of Pennsylvania Health System Committee Chair
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9:00 PANEL 1: OVERVIEW OF FLUID RESUSCITATION (15-minute presentations, each followed by 5 minutes of discussion) Ronald F. Bellamy, M.D., Colonel, USA, Retired Borden Institute, Walter Reed Army Institute of Research Trauma Epidemiology of Combat Casualties Howard Champion, M.D. University of Maryland, Baltimore Classical Shock Research vs. Resuscitation Needs Uwe Kreimeier, M.D. Department of Anesthesiology, University of Munich Resuscitation Research in Europe 10:00 BREAK 10:20 PANEL 2: TREATMENT OF BATTLEFIELD TRAUMA (15-minute presentations, each followed by 5 minutes of discussion) Issues Steven P. Bruttig, Ph.D. Novel Technologies, Inc. Issues in Trauma Treatment on the Battlefield Frank Butler, Jr., M.D., Captain, USN Naval Special Warfare Command Detachment Pensacola Issues of Trauma Treatment for Special Forces Geoffrey S. F. Ling, M.D., Ph.D. Uniformed Services University of the Health Sciences Neurological Aspects of Battlefield Trauma Strategies Michael M. Krausz, M.D. RAMBAM Medical Center, Haifa, Israel Resuscitation Strategies in the Israeli Army George C. Kramer, Ph.D. University of Texas, Galveston Hypertonic Saline/Dextran Resuscitation: Novel Methods of Delivering Fluids on the Battlefield
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Monitoring Frederick J. Pearce, Ph.D. Walter Reed Army Institute of Research Casualty Resuscitation and Monitoring Devices Under Development by the U.S. Army 12:20 p.m. LUNCH 1:20 AGENDA ACCOMODATION I (15-minute presentations, each followed by 5 minutes of discussion) Jane Shelby, Ph.D. University of Utah Melatonin Therapy in Acute Trauma (from Panel 7) Richard McCarron, M.D. Naval Medical Research Institute Hibernation as a Model for Tolerance to Ischemia (from Panel 8) 2:00 PANEL 3: ANIMAL MODELS OF HEMORHAGIC SHOCK (15-minute presentations, each followed by 5 minutes of discussion) Frederick J. Pearce, Ph.D. Walter Reed Army Institute of Research Animal Models of Hemorrhagic Shock and Physiological Responses to Hemorrhage Kenneth G. Proctor, Ph.D. University of Tennessee Models of Combined Hemorrhage and Injury Alfred Ayala, Ph.D. Rhode Island Hospital Effects of the Extent of Hypotension and Rates of Hemorrhage and Outcome in Animal Models 3:00 BREAK 3:20 PANEL 4: PATHOPHYSIOLOGY AND METABOLIC SEQUELAE (15-minute presentations, each followed by 5 minutes of discussion)
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Richard Veech, M.D., D.Phil. National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Cellular Energetics and Fluid Design Issues Ajay Verma, M.D., Ph.D., Major, USA Uniformed Services University of the Health Sciences Strategies for Supporting Energy Demand During Resuscitation Edwin A. Deitch, M.D. New Jersey Medical School Sequelae of Hemorrhagic Shock (Intestinal Ischemia, Bacterial Translocation, ARDS) Irshad H. Chaudry, Ph.D. Rhode Island Hospital Immune and Endocrine Aspects of Hemorrhage Patricia E. Molina, M.D., Ph.D. North Shore University Hospital Cytokines in Hemorrhagic Shock Timothy R. Billiar, M.D. University of Pittsburgh Role of Induced Nitric Oxide Synthase in Hemorrhagic Shock 5:20 CLOSING REMARKS David E. Longnecker, M.D. Committee Chair 5:45 ADJOURN
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National Academy of Sciences Auditorium 2101 Constitution Avenue, N.W. Washington, D.C. Friday, September 18, 1998 8:15 a.m. OPENING REMARKS David E. Longnecker, M.D. Committee Chair 8:25 PANEL 5: COMPLICATIONS OF RESUSCITATION (15-minute presentations, each followed by 5 minutes of discussion) Richard Veech, M.D., D.Phil. National Institutes of Health (for Kieran Clarke, Ph.D., Oxford University) Acute Toxicity of Lactate C. Robert Valeri, M.D. Boston University Red Blood Cells and Platelets in Hemostasis Peter Rhee, M.D. Uniformed Services University of the Health Sciences Stimulation of Inflammation by Standard Resuscitation Fluids Y. John Wang, Ph.D. Synzyme Tech., Inc., Irvine, Calif. Polynitroxyl-Albumin for Treatment of Reperfusion Injury Kenneth Mattox, M.D. Baylor University Complications of Fluid Resuscitation 10:05 BREAK 10:20 PANEL 6: NOVEL THERAPIES FOR HEMORRHAGE (15-minute presentations, each followed by 5 minutes of discussion) Alan S. Rudolph, Ph.D. Naval Research Laboratory Oxygen-Carrying Resuscitation Fluids
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Carleton J. C. Hsia, Ph.D. Synzyme Tech., Inc., Irvine, Calif. Reperfusion Injury in Hemorrhage as a Therapeutic Target Paul Segall, Ph.D. BioTime, Inc., Berkeley, Calif. Using Hextend to Treat Hemorrhagic Shock Bo E. Hedlund, Ph.D. Biomedical Frontiers, Inc. Beyond Volume Expansion: Treatment of Reperfusion Injury by Iron Chelation John L. Gainer, Ph.D. University of Virginia Fluid Additive for Promoting Oxygen Consumption T.M.S. Chang, M.D., Ph.D., M.R.C.P. McGill University, Montreal, Canada Polyhemoglobin-Superoxide Dismutase-Catalase: A New Blood Substitute 12:20 p.m. LUNCH 1:20 AGENDA ACCOMODATION II (15-minute presentations, each followed by 5 minutes of discussion) William P. Wiesmann, M.D., Colonel, USA, Retired Biostar Occult Hemorrhage Detection on the Battlefield by Means of Novel Microwave Sensors/Detectors (from Panel 2) John J. Lemasters, M.D., Ph.D. University of North Carolina Cellular Responses to Hypoxia (from Panel 4) 2:00 PANEL 7: NOVEL THERAPIES FOR HEMORRHAGE (15-minute presentations, each followed by 5 minutes of discussion) Andrew Salzman, M.D. Cincinnati Children's Hospital Treatment of Hemorrhage with MEG
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Alan Kim Johnson, Ph.D. University of Iowa Treatment of Hemorrhage with Melanocyte-Stimulating Hormones William R. Millington, Ph.D. University of Missouri, Kansas City Neurobiology of Hemorrhagic Shock Florence M. Rollwagen, Ph.D. Uniformed Services University of the Health Sciences Oral Cytokines for Treatment of Hemorrhagic Shock Radha K. Maheshwari, Ph.D. Uniformed Services University of the Health Sciences Picroliv: Beneficial Effects in Hypoxia/Ischemia Barbara A. Araneo, Ph.D. Pharmadigm Biosciences Inc., Salt Lake City, Utah Intravenous DHEA in the Treatment of Burn Syndrome 4:20 PANEL 8: HYPOTHERMIA IN TREATMENT OF HEMORRHAGE (15-minute presentations, each followed by 5 minutes of discussion) Samuel Tisherman, M.D. University of Pittsburgh Hypotensive Hypothermic Fluid Resuscitation During Uncontrolled Hemorrhagic Shock in Rats and Hypothermic Strategies for Suspended Animation with Delayed Resuscitation in Dogs Peter Safar, M.D. University of Pittsburgh Pharmacologic-Hypothermic Suspended Animation 5:00 GENERAL DISCUSSION AND CLOSING REMARKS David E. Longnecker, M.D. Committee Chair 5:30 ADJOURN
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