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PAPERBACK list:$49.50 Web:$44.55 add to cart Rights & Permissions Free PDF Access Free Resources Sign in to download PDF book and chapters PDF EXECUTIVE SUMMARY Display this book on your site! Related Titles Assessment of the Scientific Information for the Radiation Exposure Screening and Education Program Review of the Worker and Public Health Activities Program Administered by the Department of Energy and the Department of Health and Human Services Other Related Titles Review of the Hanford Thyroid Disease Study Draft Final Report (2000) Commission on Life Sciences (CLS) Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Page 156   E-mail  Facebook  Digg  Stumble  Twitter More Page 156 Front Matter (R1-R10) Public Summary (1-16) Executive Summary (17-39) 1 Introduction (40-41) 2 Overview of the HTDS Draft Final Report and Organization of the Committee (42-48) 3 Evaluation of Epidemiologic and Clinical Methods (49-60) 4 Evaluation of Dosimetric Methods and Results (61-85) 5 Evaluation of Statistical Data Analysis (86-98) 6 Statistical Power and Interpretation of the Study (99-110) 7 Comparison with Other Studies (111-113) 8 Communication of Study Results (114-136) 9 Summary of Responses to CDC (137-155) References (156-162) Appendix A: Subcommittee Activities (163-163) Appendix B: Responses to Selected Comments by the Public (168-175) Appendix C: Estimated Thyroid Doses From (176-197) Appendix D: Equation Relating to the Effect of Error is Assessing Childhood Milk Consumption (198-199) Glossary (200-200) Information on Committee Members (212-218)

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10 REFERENCES Anderson, D.M., Bates, D.J., Marsh, T.L. (1993). Estimation of ~ 945 to ~ 957 food consumption. Pacific Northwest National Laboratory: Richiand, WA. Associated Press. (1999~. Study disputes Hanford poisoned people. In The Salt Lake Tribune pp. Al2: Salt Lake City, UT. Astakhova, L.N., Anspaugh, L.R., Beebe, G., Bouville, A., Drozbovitch, V., Garber, V., Gavrilin, Y., Khrouch, V., Kuvshinnikov, A., Kuzmenkov, Y., Minenko, V., Moschik, K., Nalivko, A., Robbins, I., Shemiakina, E., Shinkarev, S., Tochitskaya, S. and Waclawiw, M. (1998~. Chernobyl- related thyroid cancer in children of Belarus: a case-control study. Radiat. Res., 150, 349-356. Beck, D.M., Darwin, R.F., Erickson, A.R., Eckert, R.~. (19924. Milk cow feed intake and milk production and distribution estimates for Phase ]:. Pacific Northwest National :Laboratory: RichIand, WA. Budowsky, J., Piro, I.D., Zegarelli, E.V., Kutscher, A.H., Barnett, A. (1956~. Radiation exposure to the head and abdomen during oral roentgenography. I. Am. Dental Ass. 52, 555- 559. Carroll, R.J., Ruppert, D., Stefanski, L.A. (1995~. Measurement Error in Nonlinear Models. Chapman, Hall: London. Cary, A. (1999~. Telephone interview. 156

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References 157 CDC. ~ ~ 999a). Congressional Briefing Document on Hanford Thyroid Disease Study, "Summary of the Study and the Primary Findings". CDC. (1999b). Summary of the Preliminary Results "The Hanford Thyroid Disease Study Draft Final Report". Centers for Disease Control and Prevention: Atlanta, GA. Davis, S. (1999a). Quoted in CDC Press Release, "Draft Report: Results Tom the Hanford Thyroid Disease Study". Davis, S. (1999b). Telephone interview. Davis, S., Kopecky, K. (1998~. Executive Summary, HTDS Draft Final Report. Fred Hutchinson Cancer Research Center: Seattle, WA. Davis, S., Kopecky, As., Hamilton, T.E. (1999~. Letter to the editor. In Seattle Post-InteRigencer: Seattle, WA. Day, N.E., Byar, D., Green, S. (1980~. Overadjustment in case- contro} studies. Am. I. Epidemiol., ~ 12, 696-706. Deonigi, D.E., Anderson, D.M., Wilfert, G.~. (1994~. Commercial milk distribution profiles and production locations. Pacific Northwest National Laboratory: Richiand, WA. Dunning, D.E., Schwarz, G. (198 ~ ). Variability of human thyroid characteristics and estimates of dose from ingested 1311. Health Phys., 40, 661-675. Dwyer, T.~., Gardner, J., Halvorsen, K., Krall, E.A., Cohen, A., Valadian. (19894. Memory of food intake in the distant past. Am. J. Epidlemiol., ~ 30, ~ 033- ~ 046. Fanis, W.T., Napier, B.A., Eslinger, P.W., Ikenberry, T.A., Shipler, D.B., Simpson, I.C. (1994~. Atmospheric pathway dosimetry report, 1944-1992. Pacific Northwest National Laboratory: RichIand, WA. FarTis, W.T., Napier, B.A., Tkenberry, T.A., Shipler, D.B. (1996~. Radiation doses from Hanford site releases to the atmosphere and the Columbia River. Health Phys., 7l, 588- 601. FHCRC. (1999a). Hanford Thyroid Disease Draft Final Report. Fred Hutchinson Cancer Research Center: Seattle, WA.

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158 Review of the HTDS Draft Final Report FHCRC. (1999b). Summary Final Report of the Hanford Thyroid Disease Study. Fred Hutchinson Cancer Research Center (Seattle,WA) and Centers for Disease Control and Prevention (Atlanta, GA). Goble, Rib. (1968~. Comparison of a calibration of the Hanford Environmental Dose Reconstruction mode} suite to the validation data sets and to the mode} with its initial parameter choice. Center for Technology Environment and Development, Clark University: Worcester, MA. Goodman, M.T., Kolonel, L., Wilkens, L. (1992~. The association of body size, reproductive factors and thyroid cancer. Br. ]. Cancer, 66, ~ ~ 80- ~ ~ 84. Hamilton, P. and others (1989~. A follow-up study of persons who had iodine-131 and other diagnostic procedures during childhood and adolescence. Rockville, MD: FDA Technical Report. Hanford Health Effects Subcommittee. Meeting transcripts (excerpts). (1998~. Salt Lake City, UT. Heeb, C.M. (1993~. Todine-131 Releases from the Hanford Site, 1944 through 1947. Pacific Northwest National Laboratory: RichIand, WA. Heeb, C.M. (1994~. Radionuclide Releases to the Atmosphere from Hanford Operations, 1944-1972. Pacific Northwest National Laboratory: RichIand, WA. Hermann, B., Hermann, F.~. (1996~. lodine-131 Release to the Atmosphere from Hanford Separations Plants for the Period May 1948 through December 1960. (A report prepared on behalf of plaintiffs in Hanford litigation.) 10 March, 1996. Hoffinan, F.O., Amaral, E., Mohrbacher, D.A., Deming, E.~. (1988~. The comparison of generic mode! predictions with Chernobyl fallout data on the transfer of radioiodine over the air-pasture-cow milk pathway. ]. Environ. Radioactivity, 8, 53-71. Hoffinan, F.O., Nair, S.K., Wichner, R. (1999~. Review of HEDR Source Term for the Atmospheric Releases of JL-131.

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References 159 SENES Oak Ridge, Inc., Center for Risk Analysis: Oak Ridge, TN. Hoffman, F.O., Thiessen, K.M., Frank, M.L., Blaylock, B.G. (1992~. A quantification of the interception and initial retention of radioactive contaminants deposited on grass by simulated rain. Atmos. Environ., 26A, 3313-3321. Holm, L. (1991~. Cancer risks after diagnotic doses of 13~{ with special reference to thyroid cancer. Cancer Detection and Prevention, ~ 5 :27-30. HTDS Newsletter. (1999~. Questions and Answers about the HTDS Results. Fred Hutchinson Cancer Research Center: Seattle, WA ICRP. (1990~. Age-dependent doses to members ofthe public from intake of radionuclides: Part 1. Pergamon Press: New York. Jacob, P., Goulko, G., Heidenreich, W.F. (1998~. Thyroid cancer risk to children calculated. Nature, 392, 31-32. Kerber, R.A., Till, I., Simon, S., Lyon, I., Thomas, D., Preston- Martin, S., Rallison, M., Lloyd, R., Stevens, W. (1993~. A cohort study of thyroid disease in relation to fallout from nuclear weapons testing. ]. Am. Med. Assoc., 270, 2076- 2082. Kolonel, L.N. (1985~. Cancer incidence among Filipinos in Hawaii and the Philippines. Monogr. Nat. Cancer Inst., 69, 93-98. Krimsky, S., Plough, A. (1988~. Er~viror~mental Hazards. Auburn House Publishing: Dover, MA. Lee,W., Chiacchierini, R., ShIeien, B., Telles, N. (1982~. Thyroid tumors following I-131 or localized X irradiation to the thyroid and pituitary glands in rats. Radiat. Res., 92, 307- 319. McTiernan, A., Weiss, N., Dating, I. (1987~. Incidence of thyroid cancer in women in relation to known or suspected risk factors for breast cancer. Cancer Res., 47, 292-295. Nagataki, S., Shibata, Y., Inoue, S., Yokoyama, N., Tzumi, M., Shimaoka, K. (1994~. Thyroid diseases among atomic bomb survivors in Nagasaki. J. Am. Med. Assoc., 272, 364- 370.

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160 Review of the HTDS Draft Final Report Napier, B.A., Simpson, I.C., Eslinger, P.W., Ramsdell, I.V., Thiede, M.E., Walters, W.H. (1994~. Validation of HEDR Models. Pacific Northwest National Laboratory: RichIand, WA. NAS/IOM. (1999). Exposure of the American People to Iodir~e-131 from Nevada Nuclear-bomb Tests: Review of the National Cancer Institute Report and Public Health Implications. National Academy Press: Washington, DC. National Research Council. (1989~. Improving Risk Communication. National Academy Press: Washington, DC. NationalResearch Council. (1998~. Letter from Chairman Jack Schull to James Smith, 27 July 1999. Board on Radiation Effects Research, National Academy of Sciences, National Research Council: Washington, DC. National Research Council. (1999~. [ester from Chairman Jack Schull to James Smith, 25 January 1999. Board on Radiation Effects Research, National Academy of Sciences, National Research Council: Washington, DC. NCI. (1997~. Estimated exposures and thyroid doses received by the American people from iodine-131 in fallout following Nevada atmospheric nuclear bomb tests. Volume I. National Cancer Institute, US National Institutes of Health: Bethesda, MD. NCRP. (1985~. Induction of Thyroid Cancer by ionizing Radiation, Report No. SO. National Council on Radiation Protection and Measurements: Bethesda, MD. Nolan, W.E. (1953~. Radiation hazards to the patient from oral roentgenography. ~l. Am. Dental Ass., 47, 681-684. Preston-Martin, S., fin, F., Duda, M., Mack, W. (1993~. A case- contro} study of thyroid cancer in women under age 55 in Shanghai (People's Republic of China). Cancer Caus. Cont., 4, 431-440. Price. D.W. (1994~. Dairy Cow Feeding Regimes for Representative Doses: HEDR Project. Pacific Northwest National Laboratory: Richiand, WA.

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References 161 Ramsdell Ir., I.V., Simonen, C.A., Burk, K.W. (1994~. Regional Atmospheric Transport Code for Hanford Emission Tracking (RATCHET). Pacific Northwest National Laboratory: Richland, WA. Ron, E., Lubin, I., Schneider, A. (1992~. Thyroid cancer incidence (letters. Nature, 360, ~ ~ 3. Ron, E., Lubin, T., Shore, R., Mabuchi, K., Modan, B., Pottern, L., Schneider, A., Tucker, M., Boice, I. (1995~. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat. Res., 141, 259-277. Ron, E., Modan, B., Preston, D., Alfandary, E., Stovall, M., Boice, I. (1989~. Thyroid neoplasia following low-dose radiation in childhood. Radiat. Res., 120, 516-531. Salvini, S., Hunter, As., Sampson, L., Stampfer, M.~., Colditz, Rosner, Willett. (1989~. Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int. ]. Epidlemiol., I S. 858-867. Sever, L.E., Hessol, N.A., Gilbert, E.S., McIntyre, I.M. (1988~. The prevalence at birth of congenital malformations in communities near the Hanford site. Am. ]. Epidemiol., 127, 243-254. Shipler, D.B., Napier, B.A., Farns, W.T., Freshley, M.D. (1996). Hanford Environmental Dose Reconstruction Project -- an overview. Health Phys., 7l, 532-544. Shore, R. and others, (1993~. Thyroid cancer among persons given x-ray treatment in infancy for an enlarged thymus gland. American Journal of Epidemiology, ~ 37: 1068- 1080. Simon, S.~., Lloyd, R., Till, I., Hawthorne, H., Gren, D., Rallison, M., Stevens, W. (1990~. Development of a method to estimate thyroid dose from fallout radiolodine in a cohort study. Health Phys., 59, 669-691. Snyder, S.F., Fa~ris, W.T., Napier, T.A., {kenberry, T.A., Gilbert, R.O. (1994~. Parameters used in the environmental pathways and radiological dose modules (DESCARTES, CIDER, and CRD codes) of the Hanford Environmental

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162 Review of the HTDS Draft Final Report Dose Reconstruction Integrated Codes (HEDRIC). Pacific Northwest National Laboratory: RichIand, WA. Steele, K.D. (1999~. Telephone interview. Swanson, S., Friedman, S.M., Bridgen, P., Covello, V., SIovic, P., Cohn, I. (June 1991~. Risk Communication Manual for Electric Utilities. Electric Power Research Institute: Palo Alto, CA. Thompson, D., Mabuchi, K., Ron, E., Soda, M., Tokunaga, M., Ochikubo, S., Sugimoto, S., Ikeda, T., Terasaki, M., Suzuki, S., Preston, D. (1994~. Cancer incidence in atomic bomb survivors. Part Il: Solid tumors, 1958-1987. Radiat. Res., 137, S17-S67. Wald, M.~. (1999~. No radiation effect found at Northwest nuclear site. In New York Times p. A20: New York NY. Warren, I.H. (1961~. Control of T-131 Releases to the Atmosphere. Hanford Atomic Products Operations: RichIand, WA. Willett, W. (19904. Nutritional Epidemiology. Oxford University Press: New York. Wong, F.~., Ron, E., Gieriowski, T., Schneider, A. (1996~. Benign thyroid tumors: general risk factors and their effects on radiation risk estimation. Am. ]. Epidemiol., 144, 728-733.

Representative terms from entire chapter:

thyroid disease