TABLE S-3 Criteria and Dietary Reference Intake Values for Selenium by Life Stage Group

Life Stage Groupa

Criterion

0 through 6 mo

Human milk content

7 through 12 mo

Human milk + solid food

1 through 3 y

Extrapolation from adult

4 through 8 y

Extrapolation from adult

9 through 13 y

Extrapolation from adult

14 through 18 y

Extrapolation from adult

19 through 30 y

Maximizing plasma glutathione peroxidase activity

31 through 50 y

Extrapolation of plasma glutathione peroxidase activity from 19 through 30 y

51 through 70 y

Extrapolation of plasma glutathione peroxidase activity from 19 through 30 y

>70 y

Extrapolation of plasma glutathione peroxidase activity from 19 through 30 y

Pregnancy

 

≤18 y

Saturation of fetal selenoprotein

19 through 50 y

Saturation of fetal selenoprotein

Lactation

 

≤18 y

Human milk content + age specific requirement

19 through 50 y

Human milk content + age specific requirement

a All groups except Pregnancy and Lactation are males and females.

b EAR = Estimated Average Requirement. The intake that meets the estimated nutrient needs of half of the individuals in a group, men and women combined.

c RDA = Recommended Dietary Allowance. The intake that meets the nutrient needs of almost all (97–98 percent) individuals in a group.

d AI = Adequate Intake. The observed average or experimentally set intake by a defined population or subgroup that appears to sustain a defined nutritional status, such as growth rate, normal circulating nutrient values, or other functional indicators of health. An AI is used if sufficient scientific evidence is not available to derive an EAR. For healthy human milk-fed infants, the AI is the mean intake. The AI is not equivalent to an RDA.

used is described for each nutrient in Chapters 5 through Chapter 8. While the various recommendations are provided as single rounded numbers for practical considerations, it is acknowledged that these values imply a precision not fully justified by the underlying data in the case of currently available human studies.

In this report, the scientific evidence related to the prevention of chronic degenerative disease was judged to be too nonspecific to be used as the basis for setting any of the recommended levels of intake. Furthermore, a quantitative relationship between the biomarkers of antioxidant function and the prevention of chronic



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