TABLE S-1 Criteria and Dietary Reference Intake Values for Vitamin C by Life Stage and Gender Group

Life Stage Group

Criterion

0 through 6 mo

Human milk content

7 through 12 mo

Human milk + solid food

1 through 3 y

Extrapolation from adult

4 through 8 y

Extrapolation from adult

9 through 13 y

Extrapolation from adult

14 through 18 y

Extrapolation from adult

19 through 30 y

Near-maximal neutrophil concentration

31 through 50 y

Extrapolation of near-maximal neutrophil concentration from 19 through 30 y

51 through 70 y

Extrapolation of near-maximal neutrophil concentration from 19 through 30 y

>70 y

Extrapolation of near-maximal neutrophil concentration from 19 through 30 y

Pregnancy

 

≤18 y

Extrapolation of near-maximal neutrophil concentration plus transfer to the fetus

19 through 50 y

Extrapolation of near-maximal neutrophil concentration plus transfer to the fetus

Lactation

 

≤18 y

Human milk content + age specific requirement

19 through 50 y

Human milk content + age specific requirement

a EAR = Estimated Average Requirement. The intake that meets the estimated nutrient needs of half of the individuals in a group.

b RDA = Recommended Dietary Allowance. The intake that meets the nutrient needs of almost all (97–98 percent) individuals in a group.

c AI = Adequate Intake. The observed average or experimentally set intake by a defined population or subgroup that appears to sustain a defined nutritional status, such as growth rate, normal circulating nutrient values, or other functional indicators of health. An AI is used if sufficient scientific evidence is not available to derive an EAR. For healthy human milk-fed infants, the AI is the mean intake. The AI is not equivalent to an RDA.

not mean that there is no potential for adverse effects resulting from high intake. When data about adverse effects are extremely limited, extra caution may be warranted.

APPROACH FOR SETTING DIETARY REFERENCE INTAKES

The scientific data used to develop Dietary Reference Intakes (DRIs) have come from observational and experimental studies. Studies published in peer-reviewed journals were the principal



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