NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

The material in this report is based on work supported by the National Science Foundation and the Defense Advanced Research Projects Agency under Grant No. DMS-9703610 and by DHHS Contract No. N01-OD-4-2139 between the National Academy of Sciences and the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project.

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