Questions? Call 800-624-6242 About | Ordering | New Menu | Items in cart [0] SEARCH

Rights & Permissions Free Resources PDF SUMMARY Display this book on your site! Related Titles Adverse Effects of Vaccines: Evidence and Causality Adverse Events Associated with Childhood Vaccines:Evidence Bearing on Casuality Other Related Titles DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis (1994) Institute of Medicine (IOM) Citation Manager Export the bibliographic data for this book in your chosen format Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Citation Manager . "Methods." DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis. Washington, DC: The National Academies Press, 1994. Please select a format: Page 5   E-mail Share on facebook Facebook Share on delicious Delicious Share on stumbleupon Stumble Share on twitter Twitter More Sharing ServicesMore The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. expensive study would not be statistically powerful enough to detect the relatively rare neurologic events of interest. Data from the pilot study (Gale et al., 1990) were reviewed by the Committee to Study the Adverse Consequences of Pertussis and Rubella Vaccines; the same data have recently been published in final form (Gale et al., 1994). Vaccine Safety Committee After completion of the IOM report Adverse Effects of Pertussis and Rubella Vaccines (IOM, 1991) IOM convened the Vaccine Safety Committee under the mandate of the National Childhood Vaccine Injury Act. The Vaccine Safety Committee reviewed evidence about possible adverse events caused by vaccines against diphtheria, tetanus, measles, mumps, polio, hepatitis B, and Haemophilus influenzae type b. The committee's report was released in 1993 (IOM, 1994). With regard to diphtheria and tetanus toxoids and encephalopathy, the Vaccine Safety Committee concluded that the evidence favors rejection of a causal relation between encephalopathy (acute or chronic) and (a) diphtheria and tetanus toxoids for pediatric use (DT), (b) tetanus and diphtheria toxoids for adult use (Td), and (c) tetanus toxoid. The committee was not charged with reexamining the adverse effects of DPT. THE CHARGE TO THE 1993 COMMITTEE TO STUDY NEW RESEARCH ON VACCINES The U.S. Public Health Service, recognizing the possible significance of the newly published data from the NCES, enlisted IOM in a new assessment of the relation between DPT and permanent neurologic damage. The IOM convened the Committee to Study New Research on Vaccines in December 1993. The charge to the committee was to evaluate the contribution of the new data from the NCES to answering the question of whether DPT is causally related to permanent neurologic damage. The committee's conclusion could be phrased in terms of the impact that it might have on the conclusion of the 1991 IOM report Adverse Effects of Pertussis and Rubella Vaccines regarding the causal relation between DPT and permanent neurologic damage. METHODS The six members of the Committee to Study New Research on Vaccines had expertise in pediatrics, neurology, and epidemiology. Each committee Page 5 Front Matter (R1-R6) Contents (R7-R8) Executive Summary (1-2) Introduction (3-3) History and Background (4-4) The Charge to the 1993 Committee to Study New Research on Vaccines (5-5) Methods (5-5) Evidence Bearing on Causality (6-10) Discussion (11-11) Conclusion (12-15) References (16-17)

Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 5
DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis expensive study would not be statistically powerful enough to detect the relatively rare neurologic events of interest. Data from the pilot study (Gale et al., 1990) were reviewed by the Committee to Study the Adverse Consequences of Pertussis and Rubella Vaccines; the same data have recently been published in final form (Gale et al., 1994). Vaccine Safety Committee After completion of the IOM report Adverse Effects of Pertussis and Rubella Vaccines (IOM, 1991) IOM convened the Vaccine Safety Committee under the mandate of the National Childhood Vaccine Injury Act. The Vaccine Safety Committee reviewed evidence about possible adverse events caused by vaccines against diphtheria, tetanus, measles, mumps, polio, hepatitis B, and Haemophilus influenzae type b. The committee's report was released in 1993 (IOM, 1994). With regard to diphtheria and tetanus toxoids and encephalopathy, the Vaccine Safety Committee concluded that the evidence favors rejection of a causal relation between encephalopathy (acute or chronic) and (a) diphtheria and tetanus toxoids for pediatric use (DT), (b) tetanus and diphtheria toxoids for adult use (Td), and (c) tetanus toxoid. The committee was not charged with reexamining the adverse effects of DPT. THE CHARGE TO THE 1993 COMMITTEE TO STUDY NEW RESEARCH ON VACCINES The U.S. Public Health Service, recognizing the possible significance of the newly published data from the NCES, enlisted IOM in a new assessment of the relation between DPT and permanent neurologic damage. The IOM convened the Committee to Study New Research on Vaccines in December 1993. The charge to the committee was to evaluate the contribution of the new data from the NCES to answering the question of whether DPT is causally related to permanent neurologic damage. The committee's conclusion could be phrased in terms of the impact that it might have on the conclusion of the 1991 IOM report Adverse Effects of Pertussis and Rubella Vaccines regarding the causal relation between DPT and permanent neurologic damage. METHODS The six members of the Committee to Study New Research on Vaccines had expertise in pediatrics, neurology, and epidemiology. Each committee

Representative terms from entire chapter:

vaccine safety