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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. ing exposure from the gastrointestinal (GI) tract. That recommendation is based on studies of various organic and inorganic antimony compounds. Toxicity is greater following exposure to 7.9 mg antimony trioxide/kg-d in 5% citric acid than to 101 mg antimony trioxide/kg-d in water, suggesting that solubility can affect antimony absorption (Fleming 1938). DistributionNo studies were identified on the tissue distribution of antimony trioxide following dermal exposure. Retired workers occupationally exposed by the inhalation route to antimony were reported to have elevated concentrations of antimony in their lung tissue as compared to non-occupationally exposed individuals (Gerhardsson et al. 1982). Following intratracheal instillation of a single dose of 1.52 mg antimony trioxide/kg in Syrian golden hamsters, the highest concentrations of antimony were measured in the lungs and liver, with lower concentrations present in the kidney, stomach, and trachea (Leffler et al. 1984). No information was found on the tissue distribution of antimony in humans following oral exposure. In rats, high concentrations of antimony were measured in the thyroid and GI contents following chronic ingestion of 2% antimony trioxide in the feed (Gross et al. 1955a). Detectable levels were also found in the spleen, kidney, heart, bone, muscle, lungs, liver, and GI tissue. Following continuous treatment of rats for 40 d. Antimony was concentrated in the thyroid, with much lower levels found in the other tissues 40 d after cessation of chronic ingestion of 2% antimony trioxide in the feed (Gross et al. 1955a). Metabolism and ExcretionNo data were identified on the metabolism or excretion of antimony trioxide following dermal exposure. Intraperitoneal injection of rats with 800 µg antimony chloride/kg did not result in detectable levels of any organic form of antimony in the bile or urine, indicating that antimony is not methylated in vivo. Antimony can form a complex with glutathione in vivo (Bailly et al. 1991). McCallum (1963) reported elevated antimony concentrations in the urine of workers occupationally exposed via inhalation to antimony, indicating that excretion by this pathway occurs in humans.
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