Chronic interstitial inflammation, granulomatous inflammation, increased alveolar macrophages

NOAEL: 0.19 (F)

0.88 (M)

LOAEL: 0.88 (F)

4.19 (M)

ND

ND

Newton et al. 1994

Rat, Fischer 344, 65/sex)

0.06, 0.51 or 4.5; 6 hr/d, 5 d/wk for 1 yr; 1-yr observation

0.01, 0.09, 0.80

Increased alveolar macrophage

LOAEL: 0.01

0.435

LOAEL: 0.004

Newton et al. 1994

Interstitial inflammation and granulomatous inflammation

NOAEL: 0.09

LOAEL: 0.80

BMC (F): 0.16

0.435

0.46

NOAEL: 0.039

LOAEL: 0.348

BMC(F): 0.074

Newton et al. 1994

Newton et al. 1994

Rat, Wistar, 50F

1.9, 5.0; 6 hr/d, 5 d/wk for 1 yr

0.3, 0.9

Discoloration and increased alveolar macrophages

LOAEL: 0.3

ND

ND

Watt 1983