has become resistant and colonized the furanone panel. Also controlled by signals is the detachment event, in which these biofilm microcolonies simply dissolve and mobilize. We can now control these two activities, and a great deal of this work comes from the ONR program and from the NSF's concentration of resources in an engineering research center staffed by four-fifths engineers and one-fifth microbiologists in the Center for Biofilm Engineering (CBE). Together, these two groups are responsible for a very important discovery in medical, environmental, and industrial microbiology.


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