Appendix B
Workshop Program
Thursday, November 8, 1990 |
|
8:30 |
Welcome: Donald Mattison, University of Pittsburgh Committee Vice-Chairman |
8:35 |
Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman |
8:45 |
Biological Factors in Two-Stage Models |
|
Presenter: Alfred Knudson, Fox Chase Cancer Center |
9:30 |
Discussant: Robert Maronpot, NIEHS |
9:50 |
Questions and Comments |
10:10 |
Break |
10:30 |
Two-Stage Clonal Expansion Model of Carcinogenesis |
|
Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center |
11:15 |
Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc. |
12:00 |
Questions and Comments |
12:15 |
Lunch |
1:15 |
Application of the Two-Stage Model to Animal Data |
|
Presenter: Samuel Cohen, University of Nebraska Medical Center |
2:00 |
Discussants: William Farland, EPA; Carl Barrett, NIEHS |
2:30 |
Questions and Comments |
2:45 |
General Discussion |
|
Leader: Richard Griesemer, NIEHS |
|
Issues: |
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• The scientific basis for two-stage models of carcinogenesis. • Can two-stage models of carcinogenesis adequately represent biological processes that may involve a variety of mechanisms? • The implications for the design of rodent bioassays. • The implications for health risk assessment. |
3:30 |
Adjourn |