Strategies That Influence Cost Containment in Animal Research Facilities (2000) / Chapter Skim
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Future Directions in Research Animal Use: Infrastructure, Cost, and Productivity
Future Directions in Research Animal Use: Infrastructure, Cost, and Productivity
Pages 53-59
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From page 53... ...
It seemed important to examine trends in the use of mice because it is the committee experience that such use will drive the need for new or renovated animal research facilities in the near future. The major increase in animal research in the last few decades has involved the use of the mouse as an experimental animal.
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From page 54... ...
This technology for defining mammalian gene function in a physiologic setting, unimaginable 20 years ago, has become one of the most widely applied and most informative tools of biologic research. Application of gene-targeted mutational analyses is likely to continue to increase demand for the mouse as a model system in the next decade, especially when coupled with powerful new technologies such as genomics and the potential power of combinatorial studies of existing or future targeted mutations.
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From page 55... ...
Examples of the application of interbreeding of lines include: · Generation of animals with polygenic mutations, using multiple mutant or transgenic backgrounds for basic studies in such fields as cancer biology, immunology, and neurobiology. The combinatorial breeding of different mutant backgrounds could generate huge increases in numbers of experimental mice.
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From page 56... ...
If the national economy stays robust, the NIH budget should grow and make resources available to continue expanding mouse work. Growth of the infrastructure portion of the National Center for Research Resources budget of the NIH has not kept pace with the need for new animal research space.
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From page 57... ...
· Alternative central animal research facilities are created through regional consortia or independent academic medical centers with outstanding histories of laboratory animal management. · Improved animal research facilities are provided that can result in better health of strains and less need for strain re-derivation or regeneration after disease outbreaks or other cataclysmic events.
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From page 58... ...
Support for these models will depend to some extent on the technologic ability to make physiologic measurements or conduct disease interventions in these animals that cannot be carried out in mouse models. Pig Transgenic pigs are more attractive than mice for modeling human vascular diseases and, potentially, organ transplantation.
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From page 59... ...
· Many strategies may prove to be useful to hedge the ongoing explosion in mouse use. These include: improved colony management; database management; techniques to maintain genetic stocks without maintaining active populations; consolidation of key mutant lines or strains into fewer facilities to eliminate redundant production while maintaining prompt distribution; and continued animal health improvements and the replacement of mice with simpler organisms when applicable.
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