Skip to main content

Veterans and Agent Orange Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans (2002) / Chapter Skim
Currently Skimming:


Pages 11-16

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 11...
... Chapter 8 of that report covers childhood cancers in general as part of a review of the scientific literature regarding herbicide and dioxin exposure and reproductive effects. SUMMARIES OF EPIDEMIOLOGIC EVIDENCE In seeking evidence for associations between health outcomes and exposure to herbicides and dioxin, many different kinds of epidemiologic studies must be considered.
Read the entire page →
From page 12...
... An elevated risk was seen for exposure before, during, and after the pregnancy, but since these were highly correlated, it was not possible to determine if preconception exposure alone would lead to increased risk of a child developing AML. This is an important consideration because the wartime exposure of male veterans to herbicides would have occurred prior to conception.
Read the entire page →
From page 13...
... While this study may have been the largest ever to examine this hypothesis, the possibility of recall bias could not be ruled out, and there was some evidence suggesting that parents of cases consistently reported more occupational exposures than parents of controls. Neither study reported the effect of paternal preconception exposures independent of maternal exposures (or vice versa)
Read the entire page →
From page 14...
... They noted that the study had a low statistical power to detect such an association and that there were few data available on exposure to specific substances. In a paper not previously reviewed in a Veterans and Agent Orange series report, Kristensen et al.
Read the entire page →
From page 15...
... The study included 1,805 cases of ALL and 528 cases of AML, including cases diagnosed through 17 years of age. It combined data from three studies conducted by the Children's Cancer Group, which represents a consortium of hospitals and medical centers in the United States and Canada that pool their cases to enable large studies of childhood cancers and thereby achieve sufficient statistical power.
Read the entire page →
From page 16...
... These analyses did not adjust for any sociodemographic or life-style factors associated with increased risk of AML, although adjustment for age and gender was achieved through the methods used to derive expected numbers of cases in Australia's community standard. No excess risk was observed for the other forms of childhood leukemia: ALL, chronic lymphocytic leukemia (CLL)
Read the entire page →

Key Terms

  • agent orange
  • increased risk
  • herbicide exposure
  • paternal exposure
  • vietnam veterans

  • childhood cancers
  • health outcome
  • epidemiologic studies
  • orange series
  • elevated risk

  • australian vietnam
  • childhood aml
  • myelogenous leukemia
  • validation study
  • occupational exposures

  • statistical power
  • previously reviewed
  • parental occupational
  • aml incidence
  • dioxin exposure

  • interview study
  • childhood cancer
  • vietnam veteran
  • risk factors
  • evidence regarding

  • childhood leukemia
  • odds ratio
  • military service
  • environmental risk
  • lymphocytic leukemia


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.