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Marine Biotechnology in the Twenty-First Century Problems, Promise, and Products (2002) / Chapter Skim
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Session 2: Genomics and Proteomics
Pages 65-68

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 65...
... This approach was designed to address microbial metabolic processes that occur at natural substrate concentrations and cell densities, which are typically about three orders of magnitude less than those in common laboratory media. The approach makes use of microtiter dishes and a newly developed procedure in which cell arrays are made on microscope slides and screened by fluorescence in situ hybridization (FISH)
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From page 66...
... Genome-enabled studies on microbial species have revealed new insights about mechanisms of microbial evolution, novel metabolic capabilities, novel approaches to the diagnosis and treatment of infectious disease, and potential biological solutions to environmental remediation and alternative energy sources. Genome sequencing still remains the most robust method for assessing the overall gene complement of any organism, and as costs for DNA sequencing have dramatically decreased, the possibility of using this approach to study new species and microbial populations has become more realistic.
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From page 67...
... Microbes have been isolated (and their genomes sequenced) from extreme environments characterized by low pH, temperatures above boiling water, pressures greater than 200 atmospheres, highly toxic metal concentrations, high radiation fluxes, high salinity, and just about every other inhospitable condition imaginable.
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From page 68...
... Starting with "simple" microbial cells and being aware that multicellular life evolved from unicellular forms, we can expect this to be a massive challenge for all of biology.
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Key Terms

  • microbial species
  • microbial evolution
  • microbial genome
  • genomics revolution
  • biological solutions

  • limited repertoire
  • sequencing technologies
  • radiation fluxes
  • including human
  • microscope slides

  • cell arrays
  • profound lessons
  • deeper understanding
  • unicellular forms
  • highly toxic

  • common laboratory
  • microbial metabolic
  • genome institute
  • additional microbes
  • approach makes

  • novel metabolic
  • genomic studies
  • microbial life
  • cell behavior
  • life evolved

  • boiling water
  • novel approaches
  • metal concentrations
  • gene complement
  • prokaryotic phyla


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